Microwave Assisted Synthesis of Novel N-(Benzo[d]Thiazol-2-yl)-2-((2,4'-Dioxospiro[Indoline-3,2'-Thiazolidin]-3'-yl)Amino)Acetamide Derivatives as Potent Antibacterial Agents

Borad, Mayuri A.; Bhoi, Manoj N.; Parmar, Jagruti A.; Patel, Hitesh D.

doi:10.18052/www.scipress.com/ILCPA.53.122

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Microwave Assisted Synthesis of Novel N-(Benzo[d]Thiazol-2-yl)-2-((2,4'-Dioxospiro[Indoline-3,2'-Thiazolidin]-3'-yl)Amino)Acetamide Derivatives as Potent Antibacterial Agents

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Abstract:

As part of continuing studies in emerging new antibacterial agent, a novel series of N-(benzo[d] thiazol-2-yl)-2-((2,4’-dioxospiro[indoline-3, 2’-thiazolidin]-3'-yl)amino)acetamide derivatives were synthesized by sequencing reaction of 2-aminobenzothiazole with chloroacetyl chloride, hydrazine hydrate, isatin and Thioglycolic acid. The novel heterocycles were characterized by elemental analyses and various spectroscopic techniques. The synthesized compounds were tested in-vitro antibacterial activity against two Gram-positive and two Gram-negative bacteria. Bacteriological results showed that compound 5c possessed a broad spectrum of antibacterial activity against the tested microorganisms.

Info:

Periodical:

International Letters of Chemistry, Physics and Astronomy (Volume 53)

Pages:

122-129

DOI:

https://doi.org/10.18052/www.scipress.com/ILCPA.53.122

Citation:

M. A. Borad et al., "Microwave Assisted Synthesis of Novel N-(Benzo[d]Thiazol-2-yl)-2-((2,4'-Dioxospiro[Indoline-3,2'-Thiazolidin]-3'-yl)Amino)Acetamide Derivatives as Potent Antibacterial Agents", International Letters of Chemistry, Physics and Astronomy, Vol. 53, pp. 122-129, 2015

Online since:

July 2015

Authors:

Mayuri A. Borad, Manoj N. Bhoi, Jagruti A. Parmar, Hitesh D. Patel

Keywords:

Antibacterial Activity, Benzothiazoles, Heterocyclic Compound, Isatin, Spiro Compound

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Open Access

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Creative Commons Attribution 4.0 International License

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Cited By:

[1] M. Bhoi, M. Borad, E. Pithawala, H. Patel, "Novel benzothiazole containing 4H-pyrimido[2,1-b]benzothiazoles derivatives: One pot, solvent-free microwave assisted synthesis and their biological evaluation", Arabian Journal of Chemistry, 2016

DOI: https://doi.org/10.1016/j.arabjc.2016.01.012

[2] M. Borad, M. Bhoi, S. Rathwa, M. Vasava, H. Patel, C. Patel, H. Pandya, E. Pithawala, J. Georrge, "Microwave-Assisted ZrSiO2 Catalysed Synthesis, Characterization and Computational Study of Novel Spiro[Indole-Thiazolidines] Derivatives as Anti-tubercular Agents", Interdisciplinary Sciences: Computational Life Sciences, 2016

DOI: https://doi.org/10.1007/s12539-016-0195-2

[3] M. Taha, M. Arbin, N. Ahmat, S. Imran, F. Rahim, "Synthesis: Small library of hybrid scaffolds of benzothiazole having hydrazone and evaluation of their β -glucuronidase activity", Bioorganic Chemistry, Vol. 77, p. 47, 2018

DOI: https://doi.org/10.1016/j.bioorg.2018.01.002