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International Letters of Chemistry, Physics and Astronomy
ILCPA Volume 53
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Synthesis and Characterization of Novel N-(Benzo[d]Thiazol-2-yl)-2-(2-(6-Chloroquinolin-4-yl)Hydrazinyl)Acetamide Derivatives Containing Quinoline Linkage as Potent Antibacterial Agents
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Synthesis and Characterization of Novel N-(Benzo[d]Thiazol-2-yl)-2-(2-(6-Chloroquinolin-4-yl)Hydrazinyl)Acetamide Derivatives Containing Quinoline Linkage as Potent Antibacterial Agents

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Abstract:

As part of ongoing studies in developing new antibacterial agent, a novel series of N-(benzo[d]thiazol-2-yl)-2-(2-(6-chloroquinolin-4-yl)hydrazinyl)acetamide derivatives was synthesized by sequencing reaction of 2-aminobenzothiazole with chloroacetylchloride, hydrazine hydrate and 4,7-dichloroquinoline. The novel heterocycles were characterized by elemental analyses and various spectroscopic techniques. The synthesized compounds were tested in-vitro antibacterial activity against two Gram-positive and two Gram-negative bacteria with standard drugs. Microbiological results showed that the synthesized compounds possessed a broad spectrum of antibacterial activity against the tested microorganisms.

Info:

Periodical:
International Letters of Chemistry, Physics and Astronomy (Volume 53)
Pages:
114-121
DOI:
https://doi.org/10.18052/www.scipress.com/ILCPA.53.114
Citation:
M. N. Bhoi et al., "Synthesis and Characterization of Novel N-(Benzo[d]Thiazol-2-yl)-2-(2-(6-Chloroquinolin-4-yl)Hydrazinyl)Acetamide Derivatives Containing Quinoline Linkage as Potent Antibacterial Agents", International Letters of Chemistry, Physics and Astronomy, Vol. 53, pp. 114-121, 2015
Online since:
July 2015
Authors:
Manoj N. Bhoi, Mayuri A. Borad, Hitesh B. Parmar, Hitesh D. Patel
Keywords:
Antibacterial Activity, Benzothiazoles, Chloroacetylchloride, Heterocyclic Compound, Quinolines
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Distribution:
Open Access

Creative Commons License
This work is licensed under a
Creative Commons Attribution 4.0 International License

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Cited By:

[1] M. Bhoi, M. Borad, E. Pithawala, H. Patel, "Novel benzothiazole containing 4H-pyrimido[2,1-b]benzothiazoles derivatives: One pot, solvent-free microwave assisted synthesis and their biological evaluation", Arabian Journal of Chemistry, 2016

DOI: https://doi.org/10.1016/j.arabjc.2016.01.012

[2] D. Gandhi, S. Agarwal, "Urea nitrate catalyzed synthesis of 2-arylbenzothiazoles using the grindstone technique", Heterocyclic Communications, Vol. 24, p. 307, 2018

DOI: https://doi.org/10.1515/hc-2018-0133

[3] M. Bhoi, M. Borad, D. Jethava, P. Archarya, E. Pithawala, C. Patel, H. Pandya, H. Patel, "Synthesis, biological evaluation and computational study of novel isoniazid containing 4H-Pyrimido[2,1-b]benzothiazoles derivatives", European Journal of Medicinal Chemistry, 2019

DOI: https://doi.org/10.1016/j.ejmech.2019.05.028

[4] A. Dorababu, "Pharmacology Profile of Recently Developed Multi‐Functional Azoles; SAR‐Based Predictive Structural Modification", ChemistrySelect, Vol. 5, p. 6730, 2020

DOI: https://doi.org/10.1002/slct.202000294
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