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International Letters of Chemistry, Physics and Astronomy
ILCPA Volume 53

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2-Aminobenzothiazole Containing Novel Schiff Bases Derivatives: Search for New Antibacterial Agents

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The benzothiazole and Schiff base moieties are crucial functionalities due to their wide variety of biological activities and have a wide range of therapeutic properties. Keeping in view the importance of these organic moieties, a new series of 2-Aminobenzothiazole containing novel Schiff bases derivatives were synthesized by sequential reaction. The structures of the synthesized compounds were confirmed by their analytical and spectral data. The synthesized compounds were evaluated for their in vitro antibacterial activity against gram positive and gram negative bacteria. Synthesized compounds showed significant activity against microorganisms, which can be correlated with the privileged heterocyclic structural scaffolds.


International Letters of Chemistry, Physics and Astronomy (Volume 53)
M. N. Bhoi et al., "2-Aminobenzothiazole Containing Novel Schiff Bases Derivatives: Search for New Antibacterial Agents", International Letters of Chemistry, Physics and Astronomy, Vol. 53, pp. 106-113, 2015
Online since:
July 2015

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[1] M. Bhoi, M. Borad, E. Pithawala, H. Patel, "Novel benzothiazole containing 4H-pyrimido[2,1-b]benzothiazoles derivatives: One pot, solvent-free microwave assisted synthesis and their biological evaluation", Arabian Journal of Chemistry, 2016


[2] N. Mohamed, N. Abd El-Ghany, "Synthesis, characterization and antimicrobial activity of novel aminosalicylhydrazide cross linked chitosan modified with multi-walled carbon nanotubes", Cellulose, 2018


[3] D. Gandhi, S. Agarwal, "Urea nitrate catalyzed synthesis of 2-arylbenzothiazoles using the grindstone technique", Heterocyclic Communications, Vol. 24, p. 307, 2018


[4] S. Abbas, H. Hanoon, Z. Abbas, K. Hussein, S. Radhi, "Synthesis, Spectral Characteristics, and Biological Activity of 1,3-Oxazepines and 1,3-Oxazepanes Derived from 6-Nitrobenzothiazol-2-amine", Russian Journal of Organic Chemistry, Vol. 56, p. 327, 2020


[5] R. Sheakh Mohamad, W. Hamad, H. Aziz, N. Dege, "Crystal structure and Hirshfeld surface analysis of (E)-N-(4-propyloxybenzylidene)benzo[d]thiazol-2-amine", Acta Crystallographica Section E Crystallographic Communications, Vol. 76, p. 1591, 2020


[6] D. Anuse, V. Desale, B. Thorat, D. Anuse, S. Jagadhani, K. Abraham, R. Yamagar, "Synthesis and Screening of Biologically Active Schiff bases of Benzothiazoles and its Zinc and Lanthanum Metal Complexes", Oriental Journal Of Chemistry, Vol. 37, p. 187, 2021

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