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International Letters of Chemistry, Physics and Astronomy
Volume 52
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Determination of the Dexlansoprazole in Bulk and Spiked Human Plasma by Extraction Spectrophotometry

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Abstract:

This paper describes a simple extraction spectrophotometric method for the quantification of dexlansoprazole in bulk and spiked human plasma. This method involves formation of stable yellow colored chloroform extractable ion-pair complex of the amino derivative of dexlansoprazole with acid dye, namely methyl orange in acidic medium. The ion-pair complexes exhibit absorption maxima at 425 nm. Dexlansoprazole can be determined up to 4-40 μg/mL by the proposed method. The effect of optimum reagent concentration was studied. The relative standard deviations (≤1. 246%) obtained in the intra-day and inter-day analyses were found to be satisfactory. The accuracy results exhibited the mean recovery and percentage error in the range of 99.137%–100.574% and 0.012%–0.863%. When applied for the assay of the dexlansoprazole in spiked human plasma sample, recovery mean values ranged from 96.495–98.960%. The proposed method is useful for the estimation of the dexlansoprazole in bulk and human plasma samples.

Info:

Periodical:
International Letters of Chemistry, Physics and Astronomy (Volume 52)
Pages:
28-38
DOI:
10.18052/www.scipress.com/ILCPA.52.28
Citation:
C. B. Sekharan et al., "Determination of the Dexlansoprazole in Bulk and Spiked Human Plasma by Extraction Spectrophotometry", International Letters of Chemistry, Physics and Astronomy, Vol. 52, pp. 28-38, 2015
Online since:
Jun 2015
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