Synthesis and Antimicrobial Activities of Novel Palladium (II) Complexes of Active Schiff’s Base Ligand Derived from 5-Bromo Isatin

Patange, Ashok N.; Yadav, Uttam M.; Desai, Pratik A.; Singare, Pravin U.

doi:10.18052/www.scipress.com/ILCPA.52.22

ILCPA > ILCPA Volume 52 > Synthesis and Antimicrobial Activities of Novel...

< Back to Volume

Synthesis and Antimicrobial Activities of Novel Palladium (II) Complexes of Active Schiff’s Base Ligand Derived from 5-Bromo Isatin

Full Text PDF

Abstract:

This paper presents the synthesis and antimicrobial studies of Palladium (II) complexes of ThioSemicarbazone Pd (L₁H)₂Cl₂and Semicarbazone Pd (L₂H)₂Cl₂derived from 5-Bromo Isatin. All complexes reported here had been characterised by¹H NMR and IR spectral studies .the complexes are diamagnetic in nature and showing square planner geometry. The IR spectral data reveals that both the Schiff’s bases behave as bidentate ligands and are co-ordinated to Pd (II) metal through the sulfur and hydrogenic nitrogen atom. All the new synthesized compounds were screened for antibacterial activity against four of the test organisms like Bacillus pumilus, Micrococcus Lutes, E.coli, Salmonella abony.

Info:

Periodical:

International Letters of Chemistry, Physics and Astronomy (Volume 52)

Pages:

22-27

DOI:

https://doi.org/10.18052/www.scipress.com/ILCPA.52.22

Citation:

A. N. Patange et al., "Synthesis and Antimicrobial Activities of Novel Palladium (II) Complexes of Active Schiff’s Base Ligand Derived from 5-Bromo Isatin", International Letters of Chemistry, Physics and Astronomy, Vol. 52, pp. 22-27, 2015

Online since:

June 2015

Authors:

Ashok N. Patange, Uttam M. Yadav, Pratik A. Desai, Pravin U. Singare

Keywords:

5-Bromo Isatin, Bacillus Pumilus, E. Coli , Micrococcus Lutes, Salmonella Abony, Schiff’s Base, Semicarbazone, Thiosemicarbazone

Export:

RIS, BibTeX, Text

Distribution:

Open Access

This work is licensed under a
Creative Commons Attribution 4.0 International License

References:

[1] Rosenberg B., Vancamp L., Krigas T., Nature, 205 (1965) 698.

[2] Jakupec M., Keppler B.K., Sigel A., Sigel H. (Eds. ), Metal Ions in Biological Systems, vol. 42, Marcel Dekker Inc. (2004).

[3] Butour S., Wimmer F., Wimmer F., Castan P., Chemico- Biological Interactions., 104 (1997)165.

[4] Bansal A. Singh R.V., Synth React Inorg Met-Org Chem., 31(2001)381.

[5] Laly S., Parameswaran G., Asian J. Chem., 5 (1993) 712.

[6] Somogyi L. Bull. Chem. Soc. Jpn., 74 (2001) 873.

[7] Da Silva J. F. M., Garden S. J., Pinto A. C., J. Braz. Chem. Soc., 12 (2001) 273.

[8] Chiyanzu I., Clarkson, C., Smith, P. J., Lehman, J., Gut, J., Rosenthal, P. J., Chibale, K., Bioorg. Med. Chem., 13 (2005)3249.

[9] Cerchiaro G., Micke G. A., Tavares, M. F. M., Ferriera, A. M. D. C., J. Mol. Catal. A: Chem., 221 (2004) 29.

[10] Varma R. S., Nobles W. L., J. Med. Chem., 10 (1967) 510.

[11] Pandeya S. N., Sriram D., Acta. Pharm. Turc., 40 (1998) 33.

[12] Pandeya S. N., Sriram D., Nath G., De Clercq, E., Eur. J. Pharm. Sci., 9 (1999) 25.

[13] Teitz, Y., Ronen D., Vansover A., Stematsky T., Riggs J. L., Antiviral Res., 24 (1994) 305.

[14] Varma R.S., Pandeya R. K., Indian J. Pharm. Sci., 46 (1982) 132.

[15] Alam M., Younas M., Zafar M.A., Naeem, Pak. J. Sci. Ind. Res., 32 (1989) 246.

[16] Smolders R.R., Waefelaer A., Francart D., Ing. Chim. (Brussels), 64 (1982)5.

[17] Md. RabiulIsmlam, Mohammad Mohsin, Bangladesh. J . Pharmacol., 2 (2007) 7.

[18] Gustavson, J. Prakt. Chem., 37(1883) 108.

[19] Kohler T., Am. Chem. Soc., 24(1900) 385.

[20] Bhagat S., Sharma R., Sawant D.M., Sharma L., Journal of Molecular Catalysis A, 244 (2006) 20.

[21] Raval A.A., Shah N.M., J. Org. Chem., 22 (1975) 305.

[22] Dershowitz S., Prokauer S., J. Org. Chem., 26 (1961) 3595.

[23] Utale P.S., Raghuwanshi P.B., Doshi A.G., Asian. J Chem., 10 (1998) 597.

[24] Naik S.M., Naik H.B., Orient. J Chem., 14 (1998) 167.

[25] Sriram D., Yogeeswari P., Thirumurugan. R.S., Bioorg. Med. Chem. Lett., 14 (2004)3923.

[26] Singh H.P., Chauhan C.S., Pandeya S.N., Sharma C.S., Srivastava B., Singhal M., Der Pharm. Lett., 2 (2004) 460.

[27] Kovala-Demertzi D., Boccarelli A., Demertzis M.A., Coluccia M., Chemotherapy, 53 (2007)148.

[28] Khan S.A., Asiri A.M., Khan A.A., Khan K.A., Zayed M.A. M., Asian Journal of Chemistry, 25 (2013) 8643.

[29] Vinod K.S., Shipra S., Ankita S., Journal of Bioinorganic Chemistry Applications, 13 (2003)1.

[30] Turdor R., Aurelian G., Anca N., Rodica G., Oriental Journal of Chemistry, 52, (2007)782.

[31] Sulekh C., Umendra K., Verma H.S., Oriental Journal of Chemistry, 19 (2003) 355.

[32] Finch R.A., Liu M.C., Cory A.H., Cory J.G., Sartorelli A.C., Adv. Enzyme Regul., 39 (1999)3.

[33] Nutting C.M., van Herpen C.M.L., Miah A. B, Bhide S.A., Machiels J.P., Buter J., Kelly C., de Raucourt D., Harrington K. J. , Annals of Oncology, 20 (2009) 1275.

DOI: https://doi.org/10.1093/annonc/mdn775

[34] Reddy V., Patil N., Patil B.R., J. Ind. Council Chem. 23 (2006) 1.

[35] Pandeya S.N., Mishra V., Singh P.N., Rupainwar D.C., Pharmacology, 37 (1998)17.

[36] Kavanagh F., (Editor) Analytical Microbology, Academic Press Inc., New York (1963) p.126.

[37] Leovac V.M., Jevtovic V.S., Jovanovic L.S., Bogdanovic S., Journal of Serbian Chemistry Society, 70 (2005) 394.

[38] Soumitra K.S., Om P.P., Bimal K.S., Journal of Transition Metal Chemistry, 23 (1998) 349.

Show More Hide

Cited By:

[1] A. Ali, S. Teoh, N. Eltayeb, M. Khadeer Ahamed, A. Abdul Majid, A. Almutaleb, "Synthesis, structure and in vitro anticancer, DNA binding and cleavage activity of palladium (II) complexes based on isatin thiosemicarbazone derivatives", Applied Organometallic Chemistry, Vol. 31, p. e3813, 2017

DOI: https://doi.org/10.1002/aoc.3813

[2] G. Munikumari, R. Konakanchi, V. Nishtala, G. Ramesh, L. Kotha, K. Chandrasekhar, C. Ramachandraiah, "Palladium(II) complexes of 5-substituted isatin thiosemicarbazones: Synthesis, spectroscopic characterization, biological evaluation and in silico docking studies", Synthetic Communications, Vol. 49, p. 146, 2019

DOI: https://doi.org/10.1080/00397911.2018.1546400