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International Letters of Chemistry, Physics and Astronomy
Volume 51
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Synthesis and In Vitro Antimicrobial Activity of 3-(5-((2-Oxo-2H-Chromen-4-yl)Thio)-4-Phenyl-Thiazol-2-yl)-2-Substitutedphenyl Thiazolidin-4-One

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Abstract:

An array of 3-(5-((2-oxo-2H-chromen-4-yl) thio)-4-phenyl thiazol-2-yl)-2-substitutedphenyl thiazolidin-4-one (7a-j) have been synthesized by using acetophenone, thiourea, 4-mercaptocoumarin and thioglycolic acid. The structures of these compounds were confirmed by IR, 1H NMR, 13C NMR and mass analysis. All the newly synthesized derivatives were evaluated for their in vitro antibacterial activity (against E. coli, P. aeruginosa, S. aureus, S. pyogenes) and antifungal activity against (C. albicans, A. niger, A. clavatus) using broth dilution technique. Some of the compounds showed good to moderate activity against the specific microbial strain.

Info:

Periodical:
International Letters of Chemistry, Physics and Astronomy (Volume 51)
Pages:
135-143
DOI:
10.18052/www.scipress.com/ILCPA.51.135
Citation:
H. R. Prajapati et al., "Synthesis and In Vitro Antimicrobial Activity of 3-(5-((2-Oxo-2H-Chromen-4-yl)Thio)-4-Phenyl-Thiazol-2-yl)-2-Substitutedphenyl Thiazolidin-4-One", International Letters of Chemistry, Physics and Astronomy, Vol. 51, pp. 135-143, 2015
Online since:
May 2015
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