A new series of thiophenyl thiazole based novel quinoxaline derivatives 4a-4t have been synthesized by base catalysed condensation reaction. In which 6-substituted 2,3-dichloroquinoxaline 1a and 4-(thiophen-2-yl) thiazol-2-amine 2b reacted in basic condition to afford intermediate 3c which reacts with various aromatic amine to form final compounds. Easy experimental procedure, high yield, and selectivity are the imperative features of this method. The identity of all the compounds has been established by 1H NMR, 13C NMR, FT-IR, and elemental analysis.
International Letters of Chemistry, Physics and Astronomy (Volume 51)
H. G. Kathrotiya and Y. T. Naliapara, "Synthesis of Thiophenyl Thiazole Based Novel Quinoxaline Derivatives", International Letters of Chemistry, Physics and Astronomy, Vol. 51, pp. 115-124, 2015