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International Letters of Chemistry, Physics and Astronomy
Volume 50

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Synthesis and Antimicrobial Screening 6-Aryl-2-(Amino/Methoxy)-4-[(4′-Difluoro Methoxy) (3′-Hydroxy) Phenyl] Nicotinonitrile

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Abstract:

A series of an easy and efficient route for the synthesis of some new 2-amino-3-cyanopyridine (4a-4i) and 2-methoxy-3-cyanopyridine (5a-5i) derivatives were synthesized through the reaction of various chalcone (3a-3i) with malononitrile in presence of ammonium acetate and sodium methoxide, respectively. The constitutions of the all synthesized compounds have been established by the IR, 1H-NMR, Mass spectral data and Elemental analysis. Furthermore, all the synthesized products were screened for their antimicrobial activity.

Info:

Periodical:
International Letters of Chemistry, Physics and Astronomy (Volume 50)
Pages:
35-42
DOI:
https://doi.org/10.18052/www.scipress.com/ILCPA.50.35
Citation:
V. N. Bhadani et al., "Synthesis and Antimicrobial Screening 6-Aryl-2-(Amino/Methoxy)-4-[(4′-Difluoro Methoxy) (3′-Hydroxy) Phenyl] Nicotinonitrile", International Letters of Chemistry, Physics and Astronomy, Vol. 50, pp. 35-42, 2015
Online since:
May 2015
Authors:
Vijay N. Bhadani, Piyush A. Patel, Heta D. Purohit, Dipak M. Purohit
Keywords:
2-Amino-3-Cyanopyridine, 2-Methoxy-3-Cyanopyridine, Antibacterial Activity, Antifungal Activity, Chalcone
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Distribution:
Open Access

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