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International Letters of Chemistry, Physics and Astronomy
ILCPA Volume 50

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Synthesis and Antimicrobial Screening 6-Aryl-2-(Amino/Methoxy)-4-[(4′-Difluoro Methoxy) (3′-Hydroxy) Phenyl] Nicotinonitrile

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A series of an easy and efficient route for the synthesis of some new 2-amino-3-cyanopyridine (4a-4i) and 2-methoxy-3-cyanopyridine (5a-5i) derivatives were synthesized through the reaction of various chalcone (3a-3i) with malononitrile in presence of ammonium acetate and sodium methoxide, respectively. The constitutions of the all synthesized compounds have been established by the IR, 1H-NMR, Mass spectral data and Elemental analysis. Furthermore, all the synthesized products were screened for their antimicrobial activity.


International Letters of Chemistry, Physics and Astronomy (Volume 50)
V. N. Bhadani et al., "Synthesis and Antimicrobial Screening 6-Aryl-2-(Amino/Methoxy)-4-[(4′-Difluoro Methoxy) (3′-Hydroxy) Phenyl] Nicotinonitrile", International Letters of Chemistry, Physics and Astronomy, Vol. 50, pp. 35-42, 2015
Online since:
May 2015

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[1] M. Mahdi, R. Al-Smaism, N. Ibrahim, "Synthesis, characterization and antibacterial evaluation of novel 2-mercaptobenzothiazole derivatives bearing 2-aminonicotinonitrile moiety", European Journal of Chemistry, Vol. 7, p. 8, 2016


[2] M. Gouda, E. Attia, M. Helal, M. Salem, "Recent Progress on Nicotinonitrile Scaffold-based Anticancer, Antitumor, and Antimicrobial Agents: A Literature Review", Journal of Heterocyclic Chemistry, 2018