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International Letters of Chemistry, Physics and Astronomy
Volume 49

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Synthesis, Spectral Studies, Antibacterial and Antifungal Activity of 2"-Methoxy-4"-[2 -(4'-Chlorophenyl)-6-Methyl Imidazo[1, 2-a]Pyridin-3-yl]-6"-Aryl Nicotinonitrile

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Abstract:

Pyridine nucleus plays an important role in medicine, agriculture and industrial chemistry. With a view of biological activities and variety of industrial applications, some new 2" – methoxy - 4" - [2 - ( 4' -chlorophenyl)-6-methyl imidazo [1, 2-a] pyridin-3-yl]-6"-aryl nicotinonitrile( 4a-4l ) has been synthesized. The products have been assayed for their biological activity against Gram +ve, Gram –ve bacteria and fungi. Some of the products showed moderate activity in concentration 50µg/ml. The structures of the products have been elucidated by IR, 1H-NMR, Mass spectral data, elemental analysis and thin layer chromatography.

Info:

Periodical:
International Letters of Chemistry, Physics and Astronomy (Volume 49)
Pages:
155-160
DOI:
https://doi.org/10.18052/www.scipress.com/ILCPA.49.155
Citation:
V.V. Bhuva et al., "Synthesis, Spectral Studies, Antibacterial and Antifungal Activity of 2"-Methoxy-4"-[2 -(4'-Chlorophenyl)-6-Methyl Imidazo[1, 2-a]Pyridin-3-yl]-6"-Aryl Nicotinonitrile", International Letters of Chemistry, Physics and Astronomy, Vol. 49, pp. 155-160, 2015
Online since:
Apr 2015
Authors:
V.V. Bhuva, V.N. Bhadani, H.D. Purohit, Dipak M. Purohit
Keywords:
2-Methoxy-3-Cyanopyridine, Antibacterial Activity, Antifungal Activity
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Distribution:
Open Access

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This work is licensed under a
Creative Commons Attribution 4.0 International License

References:

[1] D. B. Shinde, M. S. Shingare; Indian J. Chem., 30B, 450, (1991).

[2] G. A. Kileigil and R. Ertan; J. Heterocycl. Chem., 35, 1485, (1998).

[3] Saheyla Ozbey and Engin Kendi; J. Heterocycl. Chem., 35, 1485, (1998).

[4] N. Latif, N. Mishrky and N. S. Girgis; Indian J. Chem., 20B, 147-149, (1981).

[5] W. Von Behenburg, J. Engel, J. Heese and K. Thiele; Ger. often., D.E., 3, 337, 593 (Cl C07D 213/72) 1984; Chem. Abstr., 101, 130595n, (1984).

[6] L. Castedo, J. M. Quintela and R. Riguers; Eur. J. Med. Chem. Chim. Ther., 19(6), 555, 1984; Chem. Abstr., 103, 37337, (1985).

[7] M. R. Pavia, C. P. Taylor, F. M. Hershenson and S. J. Lobbestael; J. Med. Chem., 30, 1210, (1987).

[8] W. L. Hoefling, D. Elhaner and E. Reckling; VEB Leund-Werke Walter Ulbricht, Ger., 1, 193, 506, 1965; Chem. Abstr., 63, 6979, (1965).

[9] Thiele Kurt, Von Be Benburg and E. Walter; S. African 6, 905, 06, 13 Feb., (1970).

[10] B. John E.D., F. M. Peter and Freeman; Ger. often., 2, 029, 079 (Cl. A 01 N007d), 1971; Brist. Appl. (1969); Chem . Abstr., 74, 99891d, (1971).

[11] V. Scott and Joseph; Jap. Pat., 2, 803, 592, 1979; Chem. Abstr., 92, 47216, (1980).

[12] J. J. Baldwin, A. Scrialrine, G. S. Ponticeello, E. L. Engelhardt and C. S. Sweeti; J. Heterocycl. Chem., 17(3), 425, 1980; Chem. Abstr., 93, 186222, (1980).

[13] A. L. Barry; the antimicrobial acceptability test, principal and practices, edited by illus lee and febiger; 180, Bio. Abstr., 64, 25183, 1997. ( Received 01 April 2015; accepted 14 April 2015 ).

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