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International Letters of Chemistry, Physics and Astronomy
Volume 49
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Synthesis and Antimicrobial Screening of 2"-Amino-4"-[2-(4'-Chlorophenyl)-6-Methyl Imidazo[1, 2-a]Pyridine -3-yl]-6"-Aryl-4"-H-Pyran-3"-Carbonitrile

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Abstract:

3-Cyano-4,6-disubstituted 4H-pyrans are endowed with a variety of pharmacodynamic activities Looking to the interesting properties of cyanopyrans, it was considered worthwhile to synthesis some new 2"-amino-4"-[2-(4'-chlorophenyl) -6-methyl imidazo [1,2-a] pyridin-3-yl]-6"-aryl-4"-H-pyran-3"- carbonitrile ( 4a-4l ) have been synthesized. The products have been assayed for their biological activity against Gram +ve, Gram –ve bacteria and fungi. Some of the products showed moderate activity in concentration 50μg/mL. The structures of the products have been elucidated by IR, 1H-NMR, Mass spectral data, elemental analysis and thin layer chromatography.Keyw ords : Cyanopyrans; antibacterial activity; antifungal activity

Info:

Periodical:
International Letters of Chemistry, Physics and Astronomy (Volume 49)
Pages:
149-154
Citation:
V.V. Bhuva et al., "Synthesis and Antimicrobial Screening of 2"-Amino-4"-[2-(4'-Chlorophenyl)-6-Methyl Imidazo[1, 2-a]Pyridine -3-yl]-6"-Aryl-4"-H-Pyran-3"-Carbonitrile", International Letters of Chemistry, Physics and Astronomy, Vol. 49, pp. 149-154, 2015
Online since:
April 2015
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Cited By:

[1] Y. Zhu, Z. Wang, J. Zhang, J. Yu, L. Yan, Y. Li, L. Chen, X. Yan, "An Organocatalytic Synthesis of Chiral Pyrano[2,3-d ]pyrimidines through [3+3] Annulation of 1,3-Dimethyl-barbituric Acid with 2-(1-Alkynyl)-2-alken-1-ones", European Journal of Organic Chemistry, Vol. 2018, p. 347, 2018

DOI: https://doi.org/10.1002/ejoc.201701581