Paper Titles in Periodical
International Letters of Chemistry, Physics and Astronomy
ILCPA Volume 49

Subscribe to our Newsletter and get informed about new publication regulary and special discounts for subscribers!

ILCPA > ILCPA Volume 49 > Synthesis and Antimicrobial Screening of...
< Back to Volume

Synthesis and Antimicrobial Screening of 2"-Amino-4"-[2-(4'-Chlorophenyl)-6-Methyl Imidazo[1, 2-a]Pyridine -3-yl]-6"-Aryl-4"-H-Pyran-3"-Carbonitrile

Full Text PDF


3-Cyano-4,6-disubstituted 4H-pyrans are endowed with a variety of pharmacodynamic activities Looking to the interesting properties of cyanopyrans, it was considered worthwhile to synthesis some new 2"-amino-4"-[2-(4'-chlorophenyl) -6-methyl imidazo [1,2-a] pyridin-3-yl]-6"-aryl-4"-H-pyran-3"- carbonitrile ( 4a-4l ) have been synthesized. The products have been assayed for their biological activity against Gram +ve, Gram –ve bacteria and fungi. Some of the products showed moderate activity in concentration 50μg/mL. The structures of the products have been elucidated by IR, 1H-NMR, Mass spectral data, elemental analysis and thin layer chromatography.Keyw ords : Cyanopyrans; antibacterial activity; antifungal activity


International Letters of Chemistry, Physics and Astronomy (Volume 49)
V.V. Bhuva et al., "Synthesis and Antimicrobial Screening of 2"-Amino-4"-[2-(4'-Chlorophenyl)-6-Methyl Imidazo[1, 2-a]Pyridine -3-yl]-6"-Aryl-4"-H-Pyran-3"-Carbonitrile", International Letters of Chemistry, Physics and Astronomy, Vol. 49, pp. 149-154, 2015
Online since:
April 2015

[1] M. J. Anne, O'Mahony Mary Josephine, L. Stephen, D. Jacqueline; PCT Int. Appl. WO 98 27, 080; Chem. Abstr., 129, 81666d, (1998).

[2] A. Z. Elassar, A. Abdel Zaher; Pharmazie, 1998; Chem. Abstr., 129, 4562a, (1998).

[3] R. M. Shaker; Pharmazie 51(3), 1996; Chem. Abstr., 125, 10762p, (1996).

[4] D. B. Shinde, M. S. Shingare; Indian J. Chem., 30B, 450, (1991).

[5] P. Pere, G. Elisa; Span ES 511, 501, (1989).

[6] G. A. Kileigil and R. Ertan; J. Heterocycl. Chem., 35, 1485, (1998).

[7] Saheyla Ozbey and Engin Kendi; J. Heterocyclic Chem., 35, 1485, (1998).

[8] W. Wuri, Li Tiechao, M. Robert, J. Yares, E. Hinnart, M. J. Luzzio, S. A. Noble, Attardo Giorgio; Bio. Org. Med. Chem. Lett., 1998; Chem. Abstr., 129, 202833s, (1998).

[9] Y. D. Kulkarni, D. Srivastava, A. Bishnoi, P. R. Dua; J. Indian Chem. Soc., 73(45); Chem. Abstr., 125, 86440c, (1996).

[10] R. Judith, B. Geneviere, T Francois, R. Pierre, L. Stephane, P. Alan, A. Gharem; Chem. Pharm. Bull,. 1998; Chem. Abstr., 128, 180349p, (1998).

[11] Dell Colin Peter, Williams Andrew Carwyn; Eur. Pat. Appl. EP 599, 514; Chem. Abstr., 121, 108765j (1994).

[12] L. H. Jochem, V. W. E. Gerlach, B. J. Chim, E. H. Christian, M. Hropot; Eur. Pat. Appl. EP, 807, 629; Chem. Abstr., 128, 34684c, (1998).

[13] A. Dandia, V. Sehgal and P. Singh; Indian J. of Chem., 32B, 1288-91, (1993).

[14] A. Orjales, A. Berisa and L. Alonso-Cires; Indian J. of Chem., 33B, 27-31, (1994).

[15] H. I. El-Diwani, H. El-Sahrawi, S. S. Mohmoud & T. Miyase; Indian J. of Chem., 34B, 2731, (1995).

[16] A. L. Barry; the antimicrobial acceptability test, principal and practices, edited by illus lee and febiger; 180, Bio. Abstr., 64, 25183, 1997. ( Received 01 April 2015; accepted 13 April 2015 ).

Show More Hide
Cited By:

[1] Y. Zhu, Z. Wang, J. Zhang, J. Yu, L. Yan, Y. Li, L. Chen, X. Yan, "An Organocatalytic Synthesis of Chiral Pyrano[2,3-d ]pyrimidines through [3+3] Annulation of 1,3-Dimethyl-barbituric Acid with 2-(1-Alkynyl)-2-alken-1-ones", European Journal of Organic Chemistry, Vol. 2018, p. 347, 2018