Paper Titles in Periodical
International Letters of Chemistry, Physics and Astronomy
Volume 49

Subscribe to our Newsletter and get informed about new publication regulary and special discounts for subscribers!

ILCPA > Volume 49 > Synthesis and Antimicrobial Screening of...
< Back to Volume

Synthesis and Antimicrobial Screening of 2"-Amino-4"-[2-(4'-Chlorophenyl)-6-Methyl Imidazo[1, 2-a]Pyridine -3-yl]-6"-Aryl-4"-H-Pyran-3"-Carbonitrile

Full Text PDF


3-Cyano-4,6-disubstituted 4H-pyrans are endowed with a variety of pharmacodynamic activities Looking to the interesting properties of cyanopyrans, it was considered worthwhile to synthesis some new 2"-amino-4"-[2-(4'-chlorophenyl) -6-methyl imidazo [1,2-a] pyridin-3-yl]-6"-aryl-4"-H-pyran-3"- carbonitrile ( 4a-4l ) have been synthesized. The products have been assayed for their biological activity against Gram +ve, Gram –ve bacteria and fungi. Some of the products showed moderate activity in concentration 50μg/mL. The structures of the products have been elucidated by IR, 1H-NMR, Mass spectral data, elemental analysis and thin layer chromatography.Keyw ords : Cyanopyrans; antibacterial activity; antifungal activity


International Letters of Chemistry, Physics and Astronomy (Volume 49)
V.V. Bhuva et al., "Synthesis and Antimicrobial Screening of 2"-Amino-4"-[2-(4'-Chlorophenyl)-6-Methyl Imidazo[1, 2-a]Pyridine -3-yl]-6"-Aryl-4"-H-Pyran-3"-Carbonitrile", International Letters of Chemistry, Physics and Astronomy, Vol. 49, pp. 149-154, 2015
Online since:
April 2015

[1] M. J. Anne, O'Mahony Mary Josephine, L. Stephen, D. Jacqueline; PCT Int. Appl. WO 98 27, 080; Chem. Abstr., 129, 81666d, (1998).

[2] A. Z. Elassar, A. Abdel Zaher; Pharmazie, 1998; Chem. Abstr., 129, 4562a, (1998).

[3] R. M. Shaker; Pharmazie 51(3), 1996; Chem. Abstr., 125, 10762p, (1996).

[4] D. B. Shinde, M. S. Shingare; Indian J. Chem., 30B, 450, (1991).

[5] P. Pere, G. Elisa; Span ES 511, 501, (1989).

[6] G. A. Kileigil and R. Ertan; J. Heterocycl. Chem., 35, 1485, (1998).

[7] Saheyla Ozbey and Engin Kendi; J. Heterocyclic Chem., 35, 1485, (1998).

[8] W. Wuri, Li Tiechao, M. Robert, J. Yares, E. Hinnart, M. J. Luzzio, S. A. Noble, Attardo Giorgio; Bio. Org. Med. Chem. Lett., 1998; Chem. Abstr., 129, 202833s, (1998).

[9] Y. D. Kulkarni, D. Srivastava, A. Bishnoi, P. R. Dua; J. Indian Chem. Soc., 73(45); Chem. Abstr., 125, 86440c, (1996).

[10] R. Judith, B. Geneviere, T Francois, R. Pierre, L. Stephane, P. Alan, A. Gharem; Chem. Pharm. Bull,. 1998; Chem. Abstr., 128, 180349p, (1998).

[11] Dell Colin Peter, Williams Andrew Carwyn; Eur. Pat. Appl. EP 599, 514; Chem. Abstr., 121, 108765j (1994).

[12] L. H. Jochem, V. W. E. Gerlach, B. J. Chim, E. H. Christian, M. Hropot; Eur. Pat. Appl. EP, 807, 629; Chem. Abstr., 128, 34684c, (1998).

[13] A. Dandia, V. Sehgal and P. Singh; Indian J. of Chem., 32B, 1288-91, (1993).

[14] A. Orjales, A. Berisa and L. Alonso-Cires; Indian J. of Chem., 33B, 27-31, (1994).

[15] H. I. El-Diwani, H. El-Sahrawi, S. S. Mohmoud & T. Miyase; Indian J. of Chem., 34B, 2731, (1995).

[16] A. L. Barry; the antimicrobial acceptability test, principal and practices, edited by illus lee and febiger; 180, Bio. Abstr., 64, 25183, 1997. ( Received 01 April 2015; accepted 13 April 2015 ).

Show More Hide
Cited By:

[1] Y. Zhu, Z. Wang, J. Zhang, J. Yu, L. Yan, Y. Li, L. Chen, X. Yan, "An Organocatalytic Synthesis of Chiral Pyrano[2,3-d ]pyrimidines through [3+3] Annulation of 1,3-Dimethyl-barbituric Acid with 2-(1-Alkynyl)-2-alken-1-ones", European Journal of Organic Chemistry, Vol. 2018, p. 347, 2018