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International Letters of Chemistry, Physics and Astronomy
Volume 49

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Synthesis and Antimicrobial Activity of 2-{4'-[(6"-Aryl)2"-Hydroxy-3",4"-Dihydro-Pyrimidine-4"-yl]-Phenyl Amino}-6-[Bis (2'"-Chloroethyl) Amino]-4-Methoxy-1,3,5-Triazine

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Abstract:

The titled compounds (5a-5k) have been synthesized by the condensation of 2-{4'-[(3"-aryl)-2"-Propene-1"-one]-Phenyl amino}-6-[bis-2""-chloroethyl) amino]-4-methoxy-1,3,5-triazine with urea in presence of conc. HCl (0.3ml) The biological activities of these compounds have been examined against various Gram +ve, Gram –ve bacteria and fungi. The structure of the products was confirmed by IR, 1H NMR, Mass spectra and elemental analysis.

Info:

Periodical:
International Letters of Chemistry, Physics and Astronomy (Volume 49)
Pages:
137-142
DOI:
https://doi.org/10.18052/www.scipress.com/ILCPA.49.137
Citation:
P.J. Kathiriya et al., "Synthesis and Antimicrobial Activity of 2-{4'-[(6"-Aryl)2"-Hydroxy-3",4"-Dihydro-Pyrimidine-4"-yl]-Phenyl Amino}-6-[Bis (2'"-Chloroethyl) Amino]-4-Methoxy-1,3,5-Triazine", International Letters of Chemistry, Physics and Astronomy, Vol. 49, pp. 137-142, 2015
Online since:
Apr 2015
Authors:
P.J. Kathiriya, H.D. Purohit, Dipak M. Purohit
Keywords:
Antibacterial Screening, Antifungal Screening, Hydroxy Pyrimidines, S-Triazine
Export:
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Distribution:
Open Access

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This work is licensed under a
Creative Commons Attribution 4.0 International License

References:

[1] Aysel G, Seret D, Gultaze C. Kevser E; Kamil V. (2000), Ear. J. med, Chem. , 35, 359-64.

[2] Archana Shrivastva V. K.; Chandra Ramesh Kumar Ashok. (2002), Indian J. Chem. 41(1), 75; (2003) Chem. Abstr, 138, 271582.

[3] Panda J; Srinivas S. V.; Rao M. E. (2002), J. Ind. Chem. Soc., 79(9); 770-1; (2003) Chem. Abstr, 138; 153499n.

[4] Kathiriya P. J., Purohit D. M. (2010) organic chemistry, An Indian Journal, 6(4); 262, 266.

[5] Roman, Pharmazie (1990), 45; PP 214.

[6] Ashok Kumar, Verma R. S. and Jagu B. P. (1990), J. Ind. Chem. Soc., 67; 120.

[7] Ronald W. I.; Advianv A. (1997), Chem. Abstr., 126; 181346f.

[8] Mokhta H. M.; Faidailab H. M. (1987), Pharmazie, 42; 42.

[9] Tokutake N. (1997) Brit. Pat. 146936 B ; chem Abstr., 87: 10 2370.

[10] Matteson D. S., Bleenbaum M. S. , Bechtold R. A., Wo; sed R. J. (1978) J. Org. Chem., 43: 950.

[11] Akhtar M., Seth S .M. and Baduri A. (1988), Res. Ints. Lucknow India ; Chem. Abstr., 108: 150408b.

[12] Martin J. A. , Bushnell D. J., Duncan (1990), J. Med. Chem., 33 : 2145.

[13] Watanable K. A., Hurado K. and Zeidle J. (1990), J. Med. Chem. 33 : 2145.

[14] Liu, Xunyong, Lijun ; Shandong (1993), Yike Daxye Xuebou, 31(2) : 179-9.

[15] Wong W. C., Bjarat L., Mohammad R. and Charles G. (1999), PCT Int. Appl. WO 98, 51, 311 (cl. A61K 31/505), Chem. Absr., 130 : 25077w.

[16] Patane M. A., Bock M. G. and selnick H. G. (1998), PCT Int. Appl. WO 9857641 (cl. A61K31/445) Chem. Absr., 130, 81519X.

[17] Patane M. A., Bock M. G. and selnick H. G. (1999), PCT Int. Appl. WO 9854641 (cl. A61K31/445) Chem. Absr., 160, 81520X.

[18] Barry A. L. (1976), "The Antimicrobial Susceptibility Test, Principle and Practices, 4th edn (ELBS) ; 180.

[19] Kathiriya P. J., Purohit D. M. (2010) organic chemistry, An Indian Journal, 6(4); 255-257. ( Received 03 April 2015; accepted 17 April 2015 ).

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