Paper Titles in Periodical
International Letters of Chemistry, Physics and Astronomy
Volume 49

Subscribe

Subscribe to our Newsletter and get informed about new publication regulary and special discounts for subscribers!

ILCPA > Volume 49 > Synthesis and Antimicrobial Activity of...
Synthesis and Antimicrobial Activity of 2-{4'-[(6"-Aryl)2"-Hydroxy-3",4"-Dihydro-Pyrimidine-4"-yl]-Phenyl Amino}-6-[Bis (2'"-Chloroethyl) Amino]-4-Methoxy-1,3,5-Triazine
< Back to Volume

Synthesis and Antimicrobial Activity of 2-{4'-[(6"-Aryl)2"-Hydroxy-3",4"-Dihydro-Pyrimidine-4"-yl]-Phenyl Amino}-6-[Bis (2'"-Chloroethyl) Amino]-4-Methoxy-1,3,5-Triazine

Full Text PDF

Abstract:

The titled compounds (5a-5k) have been synthesized by the condensation of 2-{4'-[(3"-aryl)-2"-Propene-1"-one]-Phenyl amino}-6-[bis-2""-chloroethyl) amino]-4-methoxy-1,3,5-triazine with urea in presence of conc. HCl (0.3ml) The biological activities of these compounds have been examined against various Gram +ve, Gram –ve bacteria and fungi. The structure of the products was confirmed by IR, 1H NMR, Mass spectra and elemental analysis.

Info:

Periodical:
International Letters of Chemistry, Physics and Astronomy (Volume 49)
Pages:
137-142
DOI:
https://doi.org/10.18052/www.scipress.com/ILCPA.49.137
Citation:
P.J. Kathiriya et al., "Synthesis and Antimicrobial Activity of 2-{4'-[(6"-Aryl)2"-Hydroxy-3",4"-Dihydro-Pyrimidine-4"-yl]-Phenyl Amino}-6-[Bis (2'"-Chloroethyl) Amino]-4-Methoxy-1,3,5-Triazine", International Letters of Chemistry, Physics and Astronomy, Vol. 49, pp. 137-142, 2015
Online since:
Apr 2015
Authors:
P.J. Kathiriya, H.D. Purohit, Dipak M. Purohit
Keywords:
Antibacterial Screening, Antifungal Screening, Hydroxy Pyrimidines, S-Triazine
Export:
RIS, BibTeX, Text
Distribution:
Open Access

Creative Commons License
This work is licensed under a
Creative Commons Attribution 4.0 International License

References:

[1] Aysel G, Seret D, Gultaze C. Kevser E; Kamil V. (2000), Ear. J. med, Chem. , 35, 359-64.

[2] Archana Shrivastva V. K.; Chandra Ramesh Kumar Ashok. (2002), Indian J. Chem. 41(1), 75; (2003) Chem. Abstr, 138, 271582.

[3] Panda J; Srinivas S. V.; Rao M. E. (2002), J. Ind. Chem. Soc., 79(9); 770-1; (2003) Chem. Abstr, 138; 153499n.

[4] Kathiriya P. J., Purohit D. M. (2010) organic chemistry, An Indian Journal, 6(4); 262, 266.

[5] Roman, Pharmazie (1990), 45; PP 214.

[6] Ashok Kumar, Verma R. S. and Jagu B. P. (1990), J. Ind. Chem. Soc., 67; 120.

[7] Ronald W. I.; Advianv A. (1997), Chem. Abstr., 126; 181346f.

[8] Mokhta H. M.; Faidailab H. M. (1987), Pharmazie, 42; 42.

[9] Tokutake N. (1997) Brit. Pat. 146936 B ; chem Abstr., 87: 10 2370.

[10] Matteson D. S., Bleenbaum M. S. , Bechtold R. A., Wo; sed R. J. (1978) J. Org. Chem., 43: 950.

[11] Akhtar M., Seth S .M. and Baduri A. (1988), Res. Ints. Lucknow India ; Chem. Abstr., 108: 150408b.

[12] Martin J. A. , Bushnell D. J., Duncan (1990), J. Med. Chem., 33 : 2145.

[13] Watanable K. A., Hurado K. and Zeidle J. (1990), J. Med. Chem. 33 : 2145.

[14] Liu, Xunyong, Lijun ; Shandong (1993), Yike Daxye Xuebou, 31(2) : 179-9.

[15] Wong W. C., Bjarat L., Mohammad R. and Charles G. (1999), PCT Int. Appl. WO 98, 51, 311 (cl. A61K 31/505), Chem. Absr., 130 : 25077w.

[16] Patane M. A., Bock M. G. and selnick H. G. (1998), PCT Int. Appl. WO 9857641 (cl. A61K31/445) Chem. Absr., 130, 81519X.

[17] Patane M. A., Bock M. G. and selnick H. G. (1999), PCT Int. Appl. WO 9854641 (cl. A61K31/445) Chem. Absr., 160, 81520X.

[18] Barry A. L. (1976), "The Antimicrobial Susceptibility Test, Principle and Practices, 4th edn (ELBS) ; 180.

[19] Kathiriya P. J., Purohit D. M. (2010) organic chemistry, An Indian Journal, 6(4); 255-257. ( Received 03 April 2015; accepted 17 April 2015 ).

Show More Hide