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International Letters of Chemistry, Physics and Astronomy
ILCPA Volume 49
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Synthesis and Antimicrobial Activity of 2-{4'-[(6"-Aryl)2"-Hydroxy-3",4"-Dihydro-Pyrimidine-4"-yl]-Phenyl Amino}-6-[Bis (2'"-Chloroethyl) Amino]-4-Methoxy-1,3,5-Triazine
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Synthesis and Antimicrobial Activity of 2-{4'-[(6"-Aryl)2"-Hydroxy-3",4"-Dihydro-Pyrimidine-4"-yl]-Phenyl Amino}-6-[Bis (2'"-Chloroethyl) Amino]-4-Methoxy-1,3,5-Triazine

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Abstract:

The titled compounds (5a-5k) have been synthesized by the condensation of 2-{4'-[(3"-aryl)-2"-Propene-1"-one]-Phenyl amino}-6-[bis-2""-chloroethyl) amino]-4-methoxy-1,3,5-triazine with urea in presence of conc. HCl (0.3ml) The biological activities of these compounds have been examined against various Gram +ve, Gram –ve bacteria and fungi. The structure of the products was confirmed by IR, 1H NMR, Mass spectra and elemental analysis.

Info:

Periodical:
International Letters of Chemistry, Physics and Astronomy (Volume 49)
Pages:
137-142
DOI:
https://doi.org/10.18052/www.scipress.com/ILCPA.49.137
Citation:
P.J. Kathiriya et al., "Synthesis and Antimicrobial Activity of 2-{4'-[(6"-Aryl)2"-Hydroxy-3",4"-Dihydro-Pyrimidine-4"-yl]-Phenyl Amino}-6-[Bis (2'"-Chloroethyl) Amino]-4-Methoxy-1,3,5-Triazine", International Letters of Chemistry, Physics and Astronomy, Vol. 49, pp. 137-142, 2015
Online since:
April 2015
Authors:
P.J. Kathiriya, H.D. Purohit, Dipak M. Purohit
Keywords:
Antibacterial Screening, Antifungal Screening, Hydroxy Pyrimidines, S-Triazine
Export:
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Distribution:
Open Access

Creative Commons License
This work is licensed under a
Creative Commons Attribution 4.0 International License

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Cited By:

[1] M. Chiacchio , D. Iannazzo , R. Romeo, S. Giofrè , L. Legnani, "Pyridine and Pyrimidine Derivatives as Privileged Scaffolds in Biologically Active Agents", Current Medicinal Chemistry, Vol. 26, p. 7166, 2020

DOI: https://doi.org/10.2174/0929867325666180904125400