Paper Titles in Periodical
International Letters of Chemistry, Physics and Astronomy
Volume 49


Subscribe to our Newsletter and get informed about new publication regulary and special discounts for subscribers!

ILCPA > Volume 49 > Synthesis, Pharmacological and Insect Antifeedant...
< Back to Volume

Synthesis, Pharmacological and Insect Antifeedant Activities of some 3-(2-Naphthyl)-5-(Substituted Phenyl)-4,5-Dihydroisoxazoles

Full Text PDF


Totally thirty one 3,5-substituted aryl 4,5-dihydro isoxazole derivatives including 3-(2-naphthyl)-5-(substituted phenyl)-4,5-dihydroisoxazole have been synthesized by fly-ash:H2SO4 catalyzed cyclization of hydroxylamine hydrochloride and aryl chalcones under solvent-free conditions. The yields of the isoxazoles are more than 94%. The synthesized isoxazole were characterized by their physical constants and spectral data. The antimicrobial, antioxidant and insect antifeedant activities of the synthesized isoxazoles have been evaluated using a variety of bacterial and fungal species, DPPH radical scavenging and castor-leaf disc bioassay of 4th instar larvae Achoea Janata L methods.


International Letters of Chemistry, Physics and Astronomy (Volume 49)
G. Thirunarayanan and V. Sathiyendiran, "Synthesis, Pharmacological and Insect Antifeedant Activities of some 3-(2-Naphthyl)-5-(Substituted Phenyl)-4,5-Dihydroisoxazoles", International Letters of Chemistry, Physics and Astronomy, Vol. 49, pp. 1-14, 2015
Online since:
Apr 2015

[1] Jacobi, P. A. and Lee, K. J. Am. Chem. Soc. 119 (1997) 3409-3410.

[2] Baraldi, P. G., Barco, A., Benetti, S., Pollini, G. P. and Simoni, D. Synthesis. (1987) 857-869.

DOI: 10.1055/s-1987-28105

[3] Denmark, S. E. and Kallemeyn, J. M. J. Org. Chem. 70(2005)2839-2842.

[4] Kano, H., Adachi, I., Keido, R. and Hirose, K. Isoxazoles. XVIII. Synthesis and Pharmacological Properties of 5-Aminoalkyl- and 3-Amino alkylisosazoles and Related Derivatives. Isoxazoles. 18 (1967) 10411-10418.

[5] Pineiro, M. and Pinho e Melo, T. M. V. D. Eur. J. Org. Chem. (2009) 5287–5307.

[6] Chakraborty, B., Sharma, P. K., Rai, N. and Devi Sharma, C J. Chem. Sci. 124 (2012)679-685.

[7] Mabrour, M., Bougrin, K., Benhida, R., Loupy, A. and Sohfiaoui, M. Tetrahedron Lett. 48(2007) 443-447.

[8] Duan, P., Yang, Y., Ben, R., Yan, Y., Dai, L., Hong, H., Wu, Y. D., Wang, D., Zhang, X. and Zhao, J. Chem. Sci. 4 (2014) 1674-1578.

[9] Martorana, A., Piccionello, A. P., Buscemi, S., Giorgi, G. and Pace, A. Org. Biomol. Chem. 9(2011) 491-496.

DOI: 10.1039/c0ob00511h

[10] Hansen, T. V., Wu, P. and Fokin, V V. J. Org. Chem. 70 (2005) 7761-7764.

[11] Janaki Rama Rao, R., Bhujanga Rao, A. K. S., Sreenivas, N., Suneel Kumar, B. and Murthy, Y. L. N. J. Korean Chem. Soc. 55 (2011) 243-250.

[12] Singh, C. B. and Singh, L. W. Indian J. Chem. 45B (2006) 959-966.

[13] Gopinath, C., Rama Rao, N., Lakshmi, K., Lakshmi Prasanthi, N., Vijaya baskar, C., Prahllad, M. K. and Ramakrishna, R. J. Global Trend Pharm. Sci. 1 (2011) 26-41.

[14] G. Dou, P. Xu, Q. Li, Y. Xi, Z. Hu and, D. Shi, Molecules, 18 (2006) 13645-13653.

[15] Kiyani, H. and Ghorbani, F. Hetero Lett 3 (2013) 359-369.

[16] Strotman, N. A., Chobanian, H. R., He, J. and Wilson J. E., Org. Lett. 12 (2010)3578-3581.

[17] Nadaraj, V and Thamarai selvi, S. J. Chem. Pharm. Res. 4 (2012) 2850-2853.

[18] Shailaja, M., Manjula, A. and Vital Rao, B. Indian J. Chem. 50B (2011) 214-222.

[19] Cecchi, L., Sarlo, F. D. and Machetti, F. Eur. J. Org. Chem. (2006) 4852-4860.

[20] Rodriguez, A., Juan, A., Victoria Gomez, M., Moreno, A. and Hoz, A. Synthesis. No. 44 (2012) 000A-000D.

[21] Naik, S. and Desai, V. Green Sust. Chem. 3 (2013) 1-7.

[22] Sharath, N., Bhojya Naik, H. S., Vinay Kumar, B. and Hosekeri, J. Der Pharm. Sinica. 3 (2012) 254-265.

[23] Goel, V. Der Pharm. Sinica. 5 (2013) 284-286.

[24] Singh, S., Avor, K. S., Pouw, B., Sale, W. and Basmadjaian, G. P. Chem. Pharm. Bull. 57 (1999) 1501-1505.

[25] McMurry, J. E. Org. Synthesis. Coll. Vol. 5. 53 (1988) 70-76.

[26] Jawalekar, A. M., Reubseat, E., Rutjes, F. P. J. T. and Van delft, F. L. Chem. Commun. No. 47 (2011) 3198-3200.

[27] Hussai, S., Jadhav, S., Durrabi, A. and Rai, M. World J. Pharm. Pham. Sci. 3 (2014) 1055-1058.

[28] Pizzuti, L., Franco, M. S. F., Flores, A. F. C., Quina, F. H. and Pereira, C. M. P. (2012).

[29] Hayes, B. L. Aldrichim. Acta. 37 (2004) 66-76.

[30] Lepore, S. D., Schacht, A. L. and Wiley, M. R. Tetrahedron Lett. 43 (2002) 8777-8779.

[31] Dabholkar, V. V. and Ansari, F. Y. J. Serb. Chem. Soc. 74 (2000) 1219-1228.

[32] Hese, S. V., Kamble, R. D., Mogle, P. P., Acharya, A. P., Gaikwad, M. V., Kadam, S. N. and Dawane, B. S. Indo Amer. J. Pharm. Res. 4 (2014)278-282.

[33] Maczynski, M., Ryng, S., Artym, J., Kocieba, M., Zimecki, M., Brudnik, J. and Jodkowskf, J. T. Acta Poloniae Pham. Drug Res. 7(2014)171-83.

[34] Kashima, C. and Tsuda, Y. Bull. Chem. Soc. Jpn. 44(1973)3533-3536.

[35] Ajay Kumar, K. and Jayaroopa, P. Int. J. Pharm. Chem. Biol. Sci. 3 (2013) 294-304.

[36] Chauhan, S. S. and Joshi, Y. C. Rasayan J. Chem. 1, (2008) 475-480.

[37] Suneel Kumar, K., Tatendra Reddy, K., Vamsikanth, A., Omprakash, G. and Dubey, P. K. Der Pharm. Chem. 3 (2011) 113-122.

[38] Panda, S. S., Chowdary, P. V. R. and Jayashree, B. S. Indian J. Pharm. Sci. 71 (2009) 684-687.

[39] Joshi, V. D., Kshirsagar, M. D. and Singhal, J. Chem. Pharm. Res. 4, (2012) 3234-3238.

[40] Kachhadia, V. V., Patel, M. R. and Joshi, H. S. J. Sci. Islamic Republic Iran. 15 (2004) 47-51.

[41] Shreenivas, M. T., Kumaraswamy, B. E., Manjunathan, J. G., Chandra, U., Srinivasa, G. R. and Sherigara, B. S. Der Pharm. Chem. 3 (2011) 224-234.

[42] Ajay kumar, K., Lokeswari, D. M. and Vasanth Kumar, G. Int. J. Pharm. Sci. Drug Res. 4(2012) 236-239.

[43] Madhavi, K., Bharathi, K. and Prasad, K.V.S.R.G. Res. J. Pharm. Biol. Chem. Sci. 1 (2010) 1073-1082.

[44] Omar, F. A., Hafez, A. A. A. and Ahmed, M. S. Bull. Pharm. Sci. Assiut Univ. 27 (2004) 171-186.

[45] Rahman, M. U., Rathore, A., Siddiqui, A. A., Parveen, G. and Shah Yar, M. Biomed. Res. Int. Article Id 739056. (2014)http: /dx. doi. org/10. 1155/2014/739056.

DOI: 10.1155/2014/739056

[46] Parihar, R. T., Rathod, S. P. and Rajput, P. R. Rasayan J. Chem. 4(2011) 660-665.

[47] Garud, S. B. and Shinde, L. P. Int. J. Res. Pharm Chem. 4(2014) 46-50.

[48] Matei, I., Chiorescu, I., Ionescu, S., Merisor, E. and Hillebrand, M. (2010) Experimental and theoretical study on the photophysical properties of a pyrrolyl-isoxazole derivative. Rev. Roum. Chim. 55, 1039-1046.

[49] Bauer, A. W., Kirby, W. M. M., Sherris, J. C. and Truck, M. Am. J. Clin. Pathol. 45, (1966) 493–496.

[50] Vanangamudi, G., Subramanian, M. and Thirunarayanan, G.   Arabian. J. Chem. (2013) DOI: 10. 1016/j. arabjc. 2013. 03. 006.

[51] Dethler's, V. G Chemical Insect Attractants and Repellents, Blackistan, Philadelphia. . (1947) p.210.

[52] Thirunarayanan, G., Mayavel, P. and Thirumurthy, K. Spectrochim. Acta. 91A, (2012)18–22.

[53] Sudhir, P., Rajashree, C. and Ashok, B. E-J. Chem. 9 (2012) 1760-1772.

[54] Thirunarayanan, G. J. Saudi Chem. Soc. (2011) doi: 10. 1016/j. jscs. 2011. 10. 011.

[55] Janaki, P., Sekar, K. G. and Thirunarayanan, J. Saudi Chem. Soc. (2013) Doi. 10. 1016/j. jscs. 2012. 11. 013 ( Received 21 March 2015; accepted 04 April 2015 ).

Show More Hide