Isoxazoline derivatives shows various types of therapeutic activities like antimicrobial, anti-inflammatory, anticonvulsant, Hypoglycemic etc. getting to synthesized in view of 3-Aryl-5-[(4′-difluoromethoxy)(3′-hydroxy)phenyl]-4,5-dihydro isoxazole (4a-4i) have been synthesized. All the newly synthesized compounds were screened for their antibacterial activity against S. aureus, M. luteus (Gram-positive bacteria), E. coli, S. thyphi (Gram-negative bacteria) and antifungal activity against Candida albicans (Fungi). The biological activities (MIC) of the synthesized compounds were compared with known standard drugs.
International Letters of Chemistry, Physics and Astronomy (Volume 47)
V.N. Bhadani et al., "Synthesis and Biological Screening of 3-Aryl-5-[(4′-Difluoromethoxy)(3′-Hydroxy)Phenyl]-4,5-Dihydro Isoxazole", International Letters of Chemistry, Physics and Astronomy, Vol. 47, pp. 133-138, 2015