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International Letters of Chemistry, Physics and Astronomy
Volume 47

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Synthesis and Biological Screening of 3-Aryl-5-[(4′-Difluoromethoxy)(3′-Hydroxy)Phenyl]-4,5-Dihydro Isoxazole
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Synthesis and Biological Screening of 3-Aryl-5-[(4′-Difluoromethoxy)(3′-Hydroxy)Phenyl]-4,5-Dihydro Isoxazole

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Abstract:

Isoxazoline derivatives shows various types of therapeutic activities like antimicrobial[1], anti-inflammatory[2], anticonvulsant[3], Hypoglycemic[4] etc. getting to synthesized in view of 3-Aryl-5-[(4′-difluoromethoxy)(3′-hydroxy)phenyl]-4,5-dihydro isoxazole (4a-4i) have been synthesized. All the newly synthesized compounds were screened for their antibacterial activity against S. aureus, M. luteus (Gram-positive bacteria), E. coli, S. thyphi (Gram-negative bacteria) and antifungal activity against Candida albicans (Fungi). The biological activities (MIC) of the synthesized compounds were compared with known standard drugs.

Info:

Periodical:
International Letters of Chemistry, Physics and Astronomy (Volume 47)
Pages:
133-138
DOI:
https://doi.org/10.18052/www.scipress.com/ILCPA.47.133
Citation:
V.N. Bhadani et al., "Synthesis and Biological Screening of 3-Aryl-5-[(4′-Difluoromethoxy)(3′-Hydroxy)Phenyl]-4,5-Dihydro Isoxazole", International Letters of Chemistry, Physics and Astronomy, Vol. 47, pp. 133-138, 2015
Online since:
February 2015
Authors:
V.N. Bhadani, H.D. Purohit, Dipak M. Purohit
Keywords:
Antibacterial Activity, Antifungal Activity, Isoxazole
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Distribution:
Open Access

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