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International Letters of Chemistry, Physics and Astronomy
Volume 47

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Synthesis, Characterisation and Biological Screening of s-Triazine Based Chalcones and its Derivatization into Phenyl Pyrazolines, Isoxazoles
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Synthesis, Characterisation and Biological Screening of s-Triazine Based Chalcones and its Derivatization into Phenyl Pyrazolines, Isoxazoles

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Abstract:

Heterocyclic derivatives such as phenyl pyrazolines and isoxaxoles were prepared from s - triazine based chalcones. Chalcones (A1 - A5) are synthesised by the reaction of compound (V) with various aromatic aldehydes. Moreover, further reaction of chalcones with phenyl hydrazine hydrochloride and hydroxylamine hydrochloride in the presence of alkali gives phenyl pyrazolines (A6 - A10) and isoxazoles (A11 - A15) derivatives respectively. The structures of the newly synthesised compounds were confiremed by spectroscopic (IR, 1H NMR, 13C NMR) and elemental analysis. All the newly synthesised compounds have been screened for their antimicrobial activity against selected Gram - positive (S. aureus and S. pyogenus), Gram - negative (E. coli and P. aeruginosa) bacterial and fungal strains (C. albicans, A. niger and A. clavatus).

Info:

Periodical:
International Letters of Chemistry, Physics and Astronomy (Volume 47)
Pages:
109-119
DOI:
https://doi.org/10.18052/www.scipress.com/ILCPA.47.109
Citation:
A. Solankee and R. Tailor, "Synthesis, Characterisation and Biological Screening of s-Triazine Based Chalcones and its Derivatization into Phenyl Pyrazolines, Isoxazoles", International Letters of Chemistry, Physics and Astronomy, Vol. 47, pp. 109-119, 2015
Online since:
February 2015
Authors:
Anjani Solankee, Riki Tailor
Keywords:
Antimicrobial Activity, Chalcones, Elemental Analysis, Isoxazole, Phenyl Pyarazolines, Spectral Data
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RIS, BibTeX, Text
Distribution:
Open Access

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This work is licensed under a
Creative Commons Attribution 4.0 International License

References:

J. Quiroga, Y. Diaz, B. Insuasty, R. Abonia, M. Nogueras, J. Cobo, Tetrahedron Letters 51 (21) (2010) 2928 - 2930.

N. Sunduru, Nishi, S. Palne, P. M. S. Chavhan, S. Gupta, European Journal of Medicinal Chemistry 44 (6) (2009) 2473 - 2481.

T. Shah, V. Desai, Journal of Serbian Chemical Society 72 (5) (2007) 443 - 449.

N. Kumar, S. Tiwari, A. K. Yadav, Indian Journal of Chemistry 46B (4) (2007) 702 706.

W. J. Zhou, S. J. Ji, Z. L. Shen, Journal of Organometallic Chemistry 691 (7) (2006) 1356 -1360.

P. S. Patil, S. M. Dharmaprakash, K. Ramakrishna, H. K. Fun, R. S. S. Kumar, D. N. Rao, Journal of Crystal Growth 303 (2) (2007) 520 - 524.

M. T. Konieczny, W. Konieczny, M. Sabisz, A. Skladanowski, R. Wakiec, K. E. Augustynowicz, Z. Zwolska, Europian journal of Medicinal Chemistry 42 (5) (2007) 729 -733.

D. Kumar, N. M. Kumar, K. Akamatsu, E. Kusaka, H. Harada, T. Ito, Bioorganic Medicinal Chemistry Letters 20 (13) (2010) 3916 - 3919.

S. Ducki, R. Forrest, J. A. Hadfield, A. Kendall, N. J. Lawrence, A. T. McGown, D. Rennison, Bioorganic Medicinal Chemistry Letters 8 (9) (1998) 1051 - 1056.

Z. Nowakowska, European Journal of Medicinal Chemistry 42 (2) (2007) 125 - 137.

O. Sabzevari, S. Mahmoudian, B. Minaei, H. Paydar, Toxicology Letters 196 (2010) S213.

F. F. Barsoum, H. M. Hosni, A. S. Girgis Bioorganic Medicinal Chemistry 14 (11) (2006) 3929 - 3937.

R. Foresti, M. Hoque, D. Monti, C. J. Green, R. Motterlini, Journal of Pharmacology and Experimental Therapeutics 312 (2) (2004) 686 - 693.

N. S. Mewada, D. R. Shah, K. H. Chikhalia, International Letters of Chemistry, Physics and Astronomy 17 (3) (2014) 281- 294.

X. H. Zhang, S. K. Wu, Z. Q. Gao, C. S. Lee, S. T Lee, H. L. Kwong, Thin Solid Films 371 (1 - 2) (2000) 40 - 46.

G. Thirunarayanan, International Letters of Chemistry, Physics and Astronomy 18 (2014) 47-56.

M. Amir, H. Kumar, S. A. Khan, Bioorganic and Medicinal Chemistry Letters 18 (3) (2008) 918 - 922.

M. I. Hussain, S. Shukla, Indian Journal of Chemistry 25B (1986) 983 - 986.

A. A. Bilgin, E. Palaska, R. Sunal, and B. Gunnesel, Pharmazie 49 (1) (1994) 67 - 69.

A. Solankee, S. Solankee, G. Patel, K. Patel, R. Patel, Der Pharma Chemica 3 (1) (2011) 300 -305.

M. Shekarchi, B. P. Hamedani, L. Navidpour, N. Adib, A. Shafiee, Journal of Iranian Chemical Society 5 (1) (2008) 150 - 158.

J. Deng, T. Sanchez, N. Neamati, J. M. Briggs, Journal of Medicinal Chemistry 49 (5) (2006) 1684 - 1692.

B. J. Wakefield, D. J. Wright, Advance Heterocyclic Chemistry 25 (1979) 147 - 186.

C. Kashima, Heterocycles 12 (10) (1979) 1343 - 1368.

M. M. M. Santos, F. Natalia, I. Jim, C. J. Simon, H. B. Michael, M. L. Martins, M. Rui, Bioorganic Medicinal Chemistry Letters 20 (1) (2010) 193 -195.

A. Solankee, K. Patel, R. Patel, Elixir Organic Chemistry 44 (2012) 7316 - 7319.

V. Subash, B. Michael, U. Reaz, W. Baojie, F. G. Scott, P. A. Pavel, Journal of Medicinal Chemistry 51 (10) (2008) 1999 -(2002).

J. A. Egan, R. P. Nugent, C. N. Filer, Journal of Radioanalytical and Nuclear Chemistry 279 (3) (2009) 935 - 936.

A. Solankee, K. Kapadia, Anaciric, M. Sokovic, I. Doytchinova, A. Geronikaki, Europian Journal of medicinal chemistry 45 (2) (2010) 510 - 518.

A. Rattan, 5th ed. B. Y. Churchill Livingstone (2005) 85 - 90. ( Received 01 February 2015; accepted 12 February 2015 ).

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