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International Letters of Chemistry, Physics and Astronomy
ILCPA Volume 47
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Synthesis, Characterisation and Biological Screening of s-Triazine Based Chalcones and its Derivatization into Phenyl Pyrazolines, Isoxazoles
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Synthesis, Characterisation and Biological Screening of s-Triazine Based Chalcones and its Derivatization into Phenyl Pyrazolines, Isoxazoles

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Abstract:

Heterocyclic derivatives such as phenyl pyrazolines and isoxaxoles were prepared from s - triazine based chalcones. Chalcones (A1 - A5) are synthesised by the reaction of compound (V) with various aromatic aldehydes. Moreover, further reaction of chalcones with phenyl hydrazine hydrochloride and hydroxylamine hydrochloride in the presence of alkali gives phenyl pyrazolines (A6 - A10) and isoxazoles (A11 - A15) derivatives respectively. The structures of the newly synthesised compounds were confiremed by spectroscopic (IR, 1H NMR, 13C NMR) and elemental analysis. All the newly synthesised compounds have been screened for their antimicrobial activity against selected Gram - positive (S. aureus and S. pyogenus), Gram - negative (E. coli and P. aeruginosa) bacterial and fungal strains (C. albicans, A. niger and A. clavatus).

Info:

Periodical:
International Letters of Chemistry, Physics and Astronomy (Volume 47)
Pages:
109-119
DOI:
https://doi.org/10.18052/www.scipress.com/ILCPA.47.109
Citation:
A. Solankee and R. Tailor, "Synthesis, Characterisation and Biological Screening of s-Triazine Based Chalcones and its Derivatization into Phenyl Pyrazolines, Isoxazoles", International Letters of Chemistry, Physics and Astronomy, Vol. 47, pp. 109-119, 2015
Online since:
February 2015
Authors:
Anjani Solankee, Riki Tailor
Keywords:
Antimicrobial Activity, Chalcones, Elemental Analysis, Isoxazole, Phenyl Pyarazolines, Spectral Data
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Distribution:
Open Access

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This work is licensed under a
Creative Commons Attribution 4.0 International License

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[1] H. Ghabbour, A. El-Faham, "Crystal structure of 4-chloro-N,N-diethyl-6-(piperidin-1-yl)-1,3,5-triazin-2-amine, C12H20ClN5", Zeitschrift für Kristallographie - New Crystal Structures, Vol. 231, 2016

DOI: https://doi.org/10.1515/ncrs-2015-0106

[2] A. Sharma, Y. Jad, M. Siddiqui, B. Torre, F. Albericio, A. El-Faham, "Synthesis, Characterization, and Tautomerism of 1,3-Dimethyl Pyrimidine-2,4,6-Trione s-Triazinyl Hydrazine/Hydrazone Derivatives", Journal of Chemistry, Vol. 2017, p. 1, 2017

DOI: https://doi.org/10.1155/2017/5702962

[3] S. Murtaza, K. Mir, A. Tatheer, R. Ullah, "Synthesis and Evaluation of Chalcone and its Derivatives as Potential Anticholinergic Agents", Letters in Drug Design & Discovery, Vol. 16, p. 322, 2019

DOI: https://doi.org/10.2174/1570180815666180523085436