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Terahertz Time-Domain Spectroscopy and Low-Frequency Raman Scattering of Crystalline and Glassy Pharmaceutical Indapamide

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Abstract:

We performed terahertz time-domain spectroscopy and low-frequency Raman scattering on crystalline and glassy states of pharmaceutical indapamide (IND). We have determined the real and imaginary part of the complex dielectric constants and the imaginary part of the Raman susceptibility in the THz region. Several phonon peaks have been observed in the crystalline IND and the mutual exclusion principle of infrared and Raman spectroscopy holds in the measured frequency range. In a glassy state of IND, a broad absorption peak has been observed in both the THz and the Raman spectra with different spectral shape, and this disagreement indicates that the far-infrared and Raman light-vibration coupling constants are different in the glassy IND. A clear boson peak has been observed in the Raman spectra of the glassy IND at about 0.5 THz.

Info:

Periodical:
International Letters of Chemistry, Physics and Astronomy (Volume 46)
Pages:
16-22
DOI:
https://doi.org/10.18052/www.scipress.com/ILCPA.46.16
Citation:
Y. Kobayashi et al., "Terahertz Time-Domain Spectroscopy and Low-Frequency Raman Scattering of Crystalline and Glassy Pharmaceutical Indapamide", International Letters of Chemistry, Physics and Astronomy, Vol. 46, pp. 16-22, 2015
Online since:
Jan 2015
Authors:
Yukiko Kobayashi, Tomohiko Shibata, Tatsuya Mori, Seiji Kojima
Keywords:
Indapamide, Low-Frequency Raman Scattering, Terahertz Time-Domain Spectroscopy
Export:
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Distribution:
Open Access

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This work is licensed under a
Creative Commons Attribution 4.0 International License

References:

Z. Wojnarowska, K. Grzybowska, L. Hawelik, M. Dulski, R. Wrzalik, I. Gruszka, M. Paluch, Mol. Pharmaceutics 10 (2013) 3612.

P. Ghugare, V. Dongre, P. Karmuse, R. Rana, D. Singh, A. Kumar, Z. Filmwala, Journal of Pharmaceutical and Biomedical Analysis 51 (2010) 532.

M. Smrkolj, A. Meden, Pharmazie 61 (2006) 12.

T. Mori, H. Igawa, S. Kojima, IOP Conf. Ser.: Mater. Sci. Eng. 54 (2014) 012006.

S. Kojima, T. Shibata, H. Igawa, T. Mori, IOP Conf. Ser.: Mater. Sci. Eng. 54 (2014) 012001.

T. Mori, K. Iwamoto, S. Kushibiki, H. Honda, H. Matsumoto, N. Toyota, Phys. Rev. Lett. 106 (2011) 015501.

T. Mori, E. J. Nicol, S. Shiizuka, K. Kuniyasu, T. Nojima, N. Toyota, J. P. Carbotte, Phys. Rev. B 77 (2008) 174515.

K. Kawase, Y. Ogawa, Y. Watanabe, H. Inoue, Opt. Express 11 (2013) 2549.

J. Shen, G. Wang, D. Jiang, L. Liang, X. Xu, Optik 121 (2010) 1712.

M. Otsuka, J. Nishizawa, N. Fukura, T. Sasaki, J Infrared Milli Terahz Waves 33 (2012) 953.

P. Taday, I. Bradley, D. Arnone, M. Pepper, J. Pharm. Sci. 92 (2003) 831.

C. Strachan, T. Rades, D. Newnham, K. Gordon, M. Pepper, P. Taday, Chem. Phys. Lett. 390 (2004) 20.

C. Strachan, T. Rades, K. Gordon, JPP 59 (2007) 261.

S. Kojima, Phys. Rev. B 47 (1993) 2924.

T. Shibata, H. Igawa T. Kim, T. Mori, S. Kojima, J. Mol. Struct. 1062 (2014) 185. ( Received 30 December 2014; accepted 15 January 2015 ).

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