Bio-Potent (5-Chloro-2-Thienyl)-3-(Substituted Phenyl) Bicyclo[2.2.1]Heptane-2-yl Methanone Derivatives

Thirunarayanan, Ganesamoorthy

doi:10.18052/www.scipress.com/ILCPA.42.1

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Bio-Potent (5-Chloro-2-Thienyl)-3-(Substituted Phenyl) Bicyclo[2.2.1]Heptane-2-yl Methanone Derivatives

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Abstract:

A series of (5-chloro-2-thienyl)(3-(substituted phenyl) bicyclo [2.2.1] hept-5-en-2-yl) methanones have been synthesized by fly-ash catalyzed [4+2] cycloaddition Diels-Alder reaction of cyclopentadiene and 5-chloro-2-thienyl chalcones under cooling conditions. The yields of the methanones are more than 60%. The synthesized (5-chloro-2-thienyl)(3-(substituted phenyl) bicyclo [2.2.1] hept-5-en-2-yl) methanones are characterized by their physical constants and spectral data. The antimicrobial, antioxidant and insect antifeedant activities of synthesized methanones have been studied using their respective bacterial, fungal strains, DPPH radical scavenging activity and Dethler’s leaf-discs bioassay method.

Info:

Periodical:

International Letters of Chemistry, Physics and Astronomy (Volume 42)

Pages:

1-12

DOI:

https://doi.org/10.18052/www.scipress.com/ILCPA.42.1

Citation:

G. Thirunarayanan, "Bio-Potent (5-Chloro-2-Thienyl)-3-(Substituted Phenyl) Bicyclo[2.2.1]Heptane-2-yl Methanone Derivatives", International Letters of Chemistry, Physics and Astronomy, Vol. 42, pp. 1-12, 2015

Online since:

December 2014

Authors:

Ganesamoorthy Thirunarayanan

Keywords:

5-Chloro-2-Thienyl Chalcones, Antimicrobial Activities, Antioxidant Activity, Cyclopentadiene, Diels-Alder Reaction, Insect Antifeedant Activity

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