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Simple and Efficient Three Component One-Pot Synthesis of Pyrazolo[1,5,a]Pyrimidines

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Abstract:

A series of novel 5-(2-bromophenyl)-N-cyclohexyl-2-(methylthio)-6-nitro-7-phenyl-4,7-dihydropyrazolo [1,5-a] pyrimidine-3-carboxamides were synthesized by a one-pot reaction of 5-amino-N-cyclohexyl-3-(methylthio)-1H-pyrazole-4-carboxamide, 1-(2-bromophenyl)-2-nitroethanone and aryl aldehydes in the presence of boric acid in water at refluxing temperature. Structures of compounds were demonstrated by Fourier transform infrared, 1H NMR, 13C NMR and elemental analysis. The advantages of this method are mild reaction condition, good yields, and operational simplicity.

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Periodical:
International Letters of Chemistry, Physics and Astronomy (Volume 41)
Pages:
73-81
Citation:
A. R. Morabia and Y. T. Naliapara, "Simple and Efficient Three Component One-Pot Synthesis of Pyrazolo[1,5,a]Pyrimidines", International Letters of Chemistry, Physics and Astronomy, Vol. 41, pp. 73-81, 2015
Online since:
November 2014
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