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An Efficient One-Pot Multicomponent Synthesis and Characterization of 5-Cyano-1,2,3,4-Tetrahydropyrimidine Derivatives

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Abstract:

A series of pyrimidine-5-carbonitrile derivatives was efficiently synthesized via one-pot, multi component reaction (MCRs) of 1,3-bifunctional synthon (ethylcyano acetate), substituted pyrazole-4-carbaldehyde, and thiourea/urea in the presence of basic catalyst. The key advantages of this process are high yields, shorter reaction times, easy work-up, and purification of products by non-chromatographic method.

Info:

Periodical:
International Letters of Chemistry, Physics and Astronomy (Volume 40)
Pages:
51-60
Citation:
R.G. Vaghasiya and V.H. Shah, "An Efficient One-Pot Multicomponent Synthesis and Characterization of 5-Cyano-1,2,3,4-Tetrahydropyrimidine Derivatives", International Letters of Chemistry, Physics and Astronomy, Vol. 40, pp. 51-60, 2015
Online since:
October 2014
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D. M. D'Souza, T. J. Müller, Chem. Soc. Rev. 36 (2007) 1095.

A. Domling, Chem. Rev. 106 (2006) 17.

I. Ugi, Pure and Appl. Chem. 73 (2001) 187.

Sharma, P.; Rane, N.; Gurram, V. K. Bioorg. Med. Chem. Lett. 14 (2004) 4185.

Ito S., Masuda K., Kusano S., Nagata T., Kojima Y., Sawai N., Maeno S., US 4988704 A, (1991).

Ram V. J., Haque N., Guru P. Y., Eur. J. Med. Chem. 27 (1992) 851.

Amir M., Javed S., Kumar H., Indian J. Pharm. Sci. 69 (2007) 337.

Vega S., Alonso J., Diaz J. A., Junquera F., J. Heterocyclic Chem. 27 (1990) 269.

Hannah D. R., Stevens M. F. G., J CHEM RES 2003 (2003) 398.

Smith, P. A. S.; Kan, R. O. J. Org. Chem. 29 (1964) 2261.

Balzarini, J.; McGuigan, C. J. Antimicrob. Chemother. 50 (2002) 5.

Lee, H. W.; Kim, B. Y.; Ahn, J. B.; Kang, S. K.; Lee, J. H.; Shin, J. S.; Ahn, S. K.; Lee, S. J.; Yoon, S. S. Eur. J. Med. Chem. 40 (2005) 862.

Juby, P. F.; Hudyma, T. W.; Brown, M.; Essery, J. M.; Partyka, R. A. J. Med. Chem. 22 (1979) 263.

Gupta, A.; Kayath, H.; Ajit, S.; Geeta, S.; Mishra, K. Indian J. Pharmacol. 26 (1994) 227.

Abu-Hashem, A. A.; Youssef, M. M.; Hussein, H. A. R. J. Chinese Chem. Soc. 58 (2011) 41.

Rahaman, S. A.; Rajendra Pasad, Y.; Kumar, P.; Kumar, B. Saudi Pharm J 17 (2009) 255.

Nezu, Y.; Miyazaki, M.; Sugiyama, K.; Kajiwara, I. Pestic Sci 47 (1996) 103.

Coe, J. W.; Fliri, A. F. J.; Kaneko, T.; Larson, E. R.; US 5491234 A, (1996).

Rodrigues, A. L. S.; Rosa, J. M.; Gadotti, V. M.; Goulart, E. C.; Santos, M. M.; Silva, A. V.; Sehnem, B.; Rosa, L. S.; Gonçalves, R. M.; Corrêa, R.; Santos, A. R. S. Pharmacol Biochem Be. 82 (2005) 156.

Kumar, B.; Kaur, B.; Kaur, J.; Parmar, A.; Anand, R.; Kumar, H. Indian J Chem B 41 (2002) 1526.

Murthy, Y. L.; Saviri, R. M. R.; Parimi, A. R.; Nareesh, S. Organic Communications 6 (2013).

Abdou, I. M.; Strekowski, L. Tetrahedron 56 (2000) 8631.

Fathalla, O.; Zeid, I.; Haiba, M.; Soliman, A.; Abd-Elmoez, S. I.; El-Serwy, W. World J. Chem 4 (2009) 127.

Pore Y., Kuchekar B., Dig J Nano Biostr 3 (2008) 293. ( Received 10 October 2014; accepted 18 October 2014 ).

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