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An Efficient One-Pot Multicomponent Synthesis and Characterization of 5-Cyano-1,2,3,4-Tetrahydropyrimidine Derivatives

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Abstract:

A series of pyrimidine-5-carbonitrile derivatives was efficiently synthesized via one-pot, multi component reaction (MCRs) of 1,3-bifunctional synthon (ethylcyano acetate), substituted pyrazole-4-carbaldehyde, and thiourea/urea in the presence of basic catalyst. The key advantages of this process are high yields, shorter reaction times, easy work-up, and purification of products by non-chromatographic method.

Info:

Periodical:
International Letters of Chemistry, Physics and Astronomy (Volume 40)
Pages:
51-60
DOI:
10.18052/www.scipress.com/ILCPA.40.51
Citation:
R.G. Vaghasiya and V.H. Shah, "An Efficient One-Pot Multicomponent Synthesis and Characterization of 5-Cyano-1,2,3,4-Tetrahydropyrimidine Derivatives", International Letters of Chemistry, Physics and Astronomy, Vol. 40, pp. 51-60, 2015
Online since:
Oct 2014
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