A Convergent Approach for the Synthesis of New Pyrazolyl Bipyridinyl Substituted Coumarin Derivatives as Antimicrobials

Bhila, Varun G.; Chovatiya, Yogita L.; Patel, Chirag V.; Giri, Rakesh R.; Brahmbhatt, Dinkar I.

doi:10.18052/www.scipress.com/ILCPA.40.1

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A Convergent Approach for the Synthesis of New Pyrazolyl Bipyridinyl Substituted Coumarin Derivatives as Antimicrobials

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Abstract:

Some new 3-[3-(1-phenyl-3-aryl-1H-pyrazol-4-yl) acryloyl] coumarins 3a-f were synthesized (coumarin chalcones) by the condensation of various 3-acetyl coumarins 1 and appropriate 1-phenyl-3-aryl-1H-pyrazole-4-carbaldehyde 2. These coumarin chalcones 3a-f were then employed for the synthesis of pyrazolyl bipyridinyl substituted coumarins 7a-f, 8a-f, and 9a-f under Krohnke’s reaction condition. The characterization of all the synthesized compounds was carried out by elemental analysis, IR, ¹H-NMR, ¹³C-NMR, DEPT-135 and mass spectral analysis. In addition to that, in vitro antimicrobial competency of the title compounds was assessed against selected pathogens. Compounds 3b, 3e, 7b, 8b, 8c and 9b exhibited excellent antimicrobial activity and said to be the most proficient members of the series.

Info:

Periodical:

International Letters of Chemistry, Physics and Astronomy (Volume 40)

Pages:

1-16

DOI:

https://doi.org/10.18052/www.scipress.com/ILCPA.40.1

Citation:

V. G. Bhila et al., "A Convergent Approach for the Synthesis of New Pyrazolyl Bipyridinyl Substituted Coumarin Derivatives as Antimicrobials", International Letters of Chemistry, Physics and Astronomy, Vol. 40, pp. 1-16, 2015

Online since:

October 2014

Authors:

Varun G. Bhila, Yogita L. Chovatiya, Chirag V. Patel, Rakesh R. Giri, Dinkar I. Brahmbhatt

Keywords:

Antimicrobial Activity, Bipyridine, Coumarin, Kröhnke’s Reaction, Pyrazole

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Open Access

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Creative Commons Attribution 4.0 International License

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Cited By:

[1] S. Pasricha, P. Gahlot, "Synthetic Strategies and Biological Potential of Coumarin-Chalcone Hybrids: A New Dimension to Drug Design", Current Organic Chemistry, Vol. 24, p. 402, 2020

DOI: https://doi.org/10.2174/1385272824666200219091830