Subscribe

Subscribe to our Newsletter and get informed about new publication regulary and special discounts for subscribers!

ILCPA > Volume 4 > Thionylchloride Catalyzed Aldol Condensation:...
< Back to Volume

Thionylchloride Catalyzed Aldol Condensation: Synthesis, Spectral Correlation and Antibacterial Activities of some 3,5-Dichloro-2-Hydroxyphenyl Chalcones

Download PDF

Abstract:

A series of substituted styryl 3,5-dichloro-2-hydroxyphenyl ketones [1-(3,5-dichloro-2-hydroxy)-3-phenylprop-2-en-1-one] were synthesized using thionyl chloride assisted Crossed-Aldol reaction. The yields of chalcones were more than 80%. The synthesized chalcones were characterized by analytical and spectroscopic data. From the spectroscopic data the group frequencies were correlated with Hammett substituent constants, F and R parameters. From the results of statistical analysis the effect of substituents were discussed. The antibacterial activities of these chalcones have been evaluated using Bauer-Kirby method.

Info:

Periodical:
International Letters of Chemistry, Physics and Astronomy (Volume 4)
Pages:
17-38
DOI:
10.18052/www.scipress.com/ILCPA.4.17
Citation:
R. Arulkumaran et al., "Thionylchloride Catalyzed Aldol Condensation: Synthesis, Spectral Correlation and Antibacterial Activities of some 3,5-Dichloro-2-Hydroxyphenyl Chalcones", International Letters of Chemistry, Physics and Astronomy, Vol. 4, pp. 17-38, 2012
Online since:
Sep 2013
Export:
Distribution: