Condensation of 2-hydrazinyl-1,6-dihydro-1-methyl-6-oxo-4-isobutylpyrimidine-5-carbonitrile (3) with different aromatic aldehyde gave the corresponding 2-(Benzylidinehydrazinyl)-1,6-dihydro-6-oxo-4-isobutylpyrimidine-5-carbonitrile (4). The reaction between 1,6-dihydro-1-methyl-2-(methylthio)-6-oxo-4-isobutylpyrimidine-5-carbonitrile (2) with hydrazine hydrate furnished (3). The condensation of 1,2,3,4-tetrahydro-4-oxo-6-isobutyl-2-thioxopyrimidine-5-carbonitrile (1) with methyl iodide yielded 2. Finally the products were characterized by 1H NMR, Mass and IR Spectra.
International Letters of Chemistry, Physics and Astronomy (Volume 39)
H. Dhaval et al., "Synthesis and Characterization of some Benzylidinehydrazinyl Derivatives of Newer Pyrimidine-5-Carbonitrile Moiety", International Letters of Chemistry, Physics and Astronomy, Vol. 39, pp. 28-34, 2014