Synthesis and Characterization of 1,3,5-Trisubstituted Pyrazoline Derivatives by Ultrasonic Irradiation Method and Evaluation of its Antibacterial Activity

Raguraman, A.; Santhi, N.

doi:10.18052/www.scipress.com/ILCPA.39.219

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Synthesis and Characterization of 1,3,5-Trisubstituted Pyrazoline Derivatives by Ultrasonic Irradiation Method and Evaluation of its Antibacterial Activity

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Abstract:

A series of novel 1,3,5-trisubstituted pyrazoline derivatives (P₁-P₁₀) have been synthesized by the reaction of substituted chalcones (C₁-C₁₀) with 4-hydroxybenzhydrazide. The starting material, chalcones were prepared by claisen Schmidt condensation of 4-methylacetophenone with substituted aldehydes in the presence of sodium hydroxide in ethanol. 4-hydroxybenzhydrazide was synthesized by condensing methyl 4-hydroxybenzoate with hydrazine hydrate. The cycloaddition of chalcones with 4-hydroxybenzhydrazide gives 1, 3, 5-trisubstituted pyrazoline derivatives. The structures of synthesized derivatives were confirmed by IR, ¹HNMR and ¹³C NMR spectrum. The synthesized compounds were screened for their antibacterial and antifungal activity.

Info:

Periodical:

International Letters of Chemistry, Physics and Astronomy (Volume 39)

Pages:

219-233

DOI:

https://doi.org/10.18052/www.scipress.com/ILCPA.39.219

Citation:

A. Raguraman and N. Santhi, "Synthesis and Characterization of 1,3,5-Trisubstituted Pyrazoline Derivatives by Ultrasonic Irradiation Method and Evaluation of its Antibacterial Activity", International Letters of Chemistry, Physics and Astronomy, Vol. 39, pp. 219-233, 2014

Online since:

October 2014

Authors:

A. Raguraman, N. Santhi

Keywords:

2-Pyrazoline, 4-Methylacetophenone, Antibacterial, Antifungal, Chalcone, Ultrasonic Irradiation

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Open Access

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Creative Commons Attribution 4.0 International License

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[1] N. Mahmoodi, M. Zeydi, M. Mamaghani, N. Montazeri, "Synthesis and antibacterial evaluation of several novel tripod pyrazoline with triazine core (TPTC) compounds", Research on Chemical Intermediates, Vol. 43, p. 2641, 2017

DOI: https://doi.org/10.1007/s11164-016-2786-2

[2] S. Farooq, Z. Ngaini, "One-Pot and Two-Pot Synthesis of Chalcone based Mono and Bis-Pyrazolines", Tetrahedron Letters, p. 151416, 2019

DOI: https://doi.org/10.1016/j.tetlet.2019.151416