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International Letters of Chemistry, Physics and Astronomy
ILCPA Volume 39

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Synthesis and In Vitro Antibacterial and Antifungal Evaluation of Quinoline Analogue Azetidin and Thiazolidin Derivatives

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A library of quinoline analog two novel series of azetidin (SH1-5) and thiazolidin (SHa-e) derivatives were designed and synthesized with simple and eco-friendly methodologies. The structures of the compounds were elucidated with the aid of elemental analysis, IR, 1H-NMR and mass spectral data. These novel synthesized compounds were evaluated for antibacterial activity against two gram-positive bacteria (Staphylococcus aureus, Staphylococcus pyogenus) and two gram-negative bacteria (Pseudomonas aeruginosa, Escherichia coli). The title compounds were also studied for their antifungal activity with Candida albicans, Aspergillus niger, Aspergillus clavatus using the broth dilution technique. Most of the compounds were the best bio-active desired antibacterial analog with less MIC value against different tested strains.


International Letters of Chemistry, Physics and Astronomy (Volume 39)
S. M. Prajapati et al., "Synthesis and In Vitro Antibacterial and Antifungal Evaluation of Quinoline Analogue Azetidin and Thiazolidin Derivatives", International Letters of Chemistry, Physics and Astronomy, Vol. 39, pp. 195-210, 2014
Online since:
October 2014

U. Desai, S. Mitragotri, T. Thopate, D. Pore, P. Wadgaonkarb, Arkivoc 15 (2006) 198204.

E.E. Ebenso, M.M. Kabanda, T. Arslan, M. Saracoglu, F. Kandemirli, L. C. Murulana, A. K. Singh, S. K. Shukla, B. Hammouti, K. Khaled, Int. J. Electrochem. Sci. 7 (2012).

S. Bawa, S. Kumar, S. Drabu, R. Kumar, J. Pharm. Bioallied. Sci. 2 (2010) 64-71.

M. Ozyanik, S. Demirci, H. Bektas, N. Demirbas, A. Demirbas, S.A. Karaoglu, Turk. J. Chem. 36 (2012) 233-246.

P.R. Graves, J.J. Kwiek, P. Fadden, R. Ray, K. Hardeman, A.M. Coley, M. Foley, T.A. Haystead, Mol. Pharmacol. 62 (2002) 1364-1372.

N. Ahmed, K.G. Brahmbhatt, S. Sabde, D. Mitra , I. Singh, K. K. Bhutani, Bioorg. Med. Chem. 18 (2010) 2872-2879.

D.K. Shukla, S.D. Srivastava, Indian J. Chem. 47B (2008) 463.

T.R. Rawat, S.D. Srivastava, Indian J. Chem. 37B (1998) 91.

Nema, S.K. Srivastava, J. Indian Chem. Soc. 84 (2007) 1037.

V.V. Mulwad, A.A. Mir, J. Korean Chem. Soc. 52 (2008) 649.

A.K. Parikh, P.S. Oza, S.B. Bhatt, Indian J. Chem. 44B (2005) 585.

R.B. Patel, P.S. Desai, K.H. Chikhalia, Indian J. Chem. 45B (2006) 773.

S.K. Srivastava, S. Srivastava, S.D. Srivastava, Indian J. Chem. 38B (2000) 464.

S.K. Srivastava, S.L. Srivastava, S.D. Srivastava, Indian J. Chem. 39B (1999) 183.

E. Alonsodel, C. Pozo, J. Gonzalez, Synlett. 1 (2002) 69.

J.W. Skiles, D. McNeil, Tetrahedron Lett. 31 (1990) 7277.

Nefzi, J.M. Ostresh, R.A. Houghten, Chem. Rev. 97 (1997) 449.

R.G. Frazen, J. Comb. Chem. 2 (2000) 195.

M.L. Barreca, E.D. Clercq, J. Med. Chem. 45 (2002) 5410.

T. Takematsu, K. Yokoyama, K. Ikeda, Y. Haashi, E. Taniyama, Japanese Patent 75 (1975) 121.

T. Zsolnai, Acta Phytopathol. Acad. Sci. Hung. 9 (1974) 125.

C.R. Harris, S.A. Turnbull, Can. Entomol. 109 (1977) 1109.

J. Mohan, V.K. Chadha, H.S. Chaudhary, B.D. Sharma, H.K. Pujari, L.N. Mohapatra, Ind. J. Exp. Biol. 10 (1972) 37.

E.B. Akerblom, J. Med. Chem. 17 (1974) 609.

Dandia, R. Singh, S. Khaturia, C. Merienne, G. Morgantc, A. Loupyd, Bioorg. Med. Chem. 14 (2006) 2409.

R. Ottana, E. Mazzon, L. Dugo, F. Monforte, R. Maccari, L. Sautebin, G. Deluca, M.G. Vigorita, S. Alcaro, F. Ortuso, A.P. Caputi, S. Cuzzocrea, Eur. J. Pharmacol. 448 (2002) 71.

Goel, A. Kumar, Eur. J. Med. Chem. 34 (1999) 265.

R. Ottana, R. Maccari, M.G. Bruno. A. Rotondo, A. Rossi, G. Chiricosta, R.D. Paola, L. Sautebin, S. Cuzzocread, M.G. Vigorita, Bioorg. Med. Chem. 13 (2005) 4243.

N. Karali, A. Kocabalkanli, A. Gursoy, O. Ates, II Farmaco 57 (2002) 589.

T. Srivastava, A.K. Gaikwad, W. Haq, S. Sinha, S.B. Katti, Arkivoc. 2 (2005) 120.

M.L. Barreca, Bioorg. Med. Chem. Lett. 11 (2001) 1793.

V. Gududuru, Bioorg. Med. Chem. Lett. 14 (2004) 5289.

S.M. Prajapati, K.D. Patel, R.H. Vekariya, S.N. Panchal, H. D. Patel, RSC Adv. 4 (2014) 24463-24476.

S.J. Wadher, M.P. Puranik, N.A. Karande, P.G. Yeole, Int. J. Pharm. Tech. Res. 1 (2009) 22-33.

S.Β. Desai, P.B. Desai, K.R. Desai, Heterocycl. Commun. 7 (2001) 83-90. ( Received 20 September 2014; accepted 01 October 2014 ).

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[2] A. Barakat, S. Soliman, A. Al-Majid, M. Ali, M. Islam, Y. Elshaier, H. Ghabbour, "New spiro-oxindole constructed with pyrrolidine/thioxothiazolidin-4-one derivatives: Regioselective synthesis, X-ray crystal structures, Hirshfeld surface analysis, DFT, docking and antimicrobial studies", Journal of Molecular Structure, Vol. 1152, p. 101, 2018


[3] K. Patel, R. Vekariya, N. Prajapati, D. Patel, H. Patel, T. Shaikh, D. Rajani, S. Rajani, N. Shah, D. Jhala, "Synthesis of N' -(Quinazolin-4-yl)isonicotinohydrazides and their biological screening, docking and ADME studies", Arabian Journal of Chemistry, 2018


[4] D. Daraji, K. Patel, H. Patel, D. Rajani, "Synthesis, In Vitro Biological Screening, and In Silico Computational Studies of Some Novel Imidazole-2-thiol Derivatives", Journal of Heterocyclic Chemistry, 2018

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