Synthesis, Spectral Correlations and Biological Activities of Some (E)-[4-(Substituted Benzylidene Amino)Phenyl] (Phenyl) Methanones

A series of Schiff’s bases have been synthesized by fly-ash:p-toluenesulfonic acid (fly-ash:PTS) catalyzed microwave assisted oxidative coupling of arylamines and substituted benzaldehydes under solvent-free condition. The synthesized Schiff’s bases are characterized by their physical constants, analytical and spectroscopic data. The group frequencies of imines such as IR (v, cm^–1) and NMR (δ, ppm) spectral data was correlated with Hammett substituent constants, F and R parameters using single and multi-linear regression analysis. The antimicrobial activities of these Schiff’s bases have been studied using Bauer-Kirby method.