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IR and <sup>1</sup>H NMR Spectral Studies of some 2-Amino-4-Isopropyl-6-Methoxy-N-Phenylpyrimidine-5-Carboxamides: Assessment of Substituent Effects
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IR and 1H NMR Spectral Studies of some 2-Amino-4-Isopropyl-6-Methoxy-N-Phenylpyrimidine-5-Carboxamides: Assessment of Substituent Effects

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Abstract:

A series of 2-Amino-4-isopropyl-6-methoxy-N-phenylpyrimidine-5-carboxamide compounds have been synthesized from various substituted dithioacetal and guanidine. The purities of these compounds were checked by their physical constants, UV, IR, NMR and MASS spectral data. The IR and 1HNMR spectral data of these compounds have been correlated with Hammett sigma constants, F and R parameters using single and multi-linear regression analysis. From the results of statistical analysis, the effects of substituents on the spectral group frequencies have been discussed.

Info:

Periodical:
International Letters of Chemistry, Physics and Astronomy (Volume 38)
Pages:
15-25
DOI:
https://doi.org/10.18052/www.scipress.com/ILCPA.38.15
Citation:
R. Arulkumaran et al., "IR and 1H NMR Spectral Studies of some 2-Amino-4-Isopropyl-6-Methoxy-N-Phenylpyrimidine-5-Carboxamides: Assessment of Substituent Effects", International Letters of Chemistry, Physics and Astronomy, Vol. 38, pp. 15-25, 2014
Online since:
September 2014
Authors:
R. Arulkumaran, R. Sundararajan, V. Manikandan, V. Sathiyendiran, S. Pazhamalai, Ganesamoorthy Thirunarayanan
Keywords:
2-Amino-4-Isopropyl-6-Methoxy-N-Phenylpyrimidine-5-Carboxamides, IR Spectra, NMR Spectra, Substituent Effects
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References:

[1] T. Panneer Selvam, C. Richa James, P. Vijaysarathy Dniandev, S. Karyn Valzita, Res. in Phar. 2(4) (2012) 01-09.

[2] L. W. Hertel, G. B. Boder, J. S. Kroin, et al., Cancer Res. 50 (1990) 4417- 4422.

[3] K. Desai, R. Patel, K. Chikhalia, J. Ind. Chem. 45(B) (2006) 773-778.

[4] A. E. Amr, M. S. Nermien, M. M. Abdulla, Monatsh. Chem., 138 (2007) 699-707.

[5] N. Fujiwara, T. Nakajima, Y. Ueda, H. Fujita, H. Kawakami, Bioorg. Med. Chem. 16 (2008) 9804-9816.

[6] L. Ballell, R. A. Field, G. A. C. Chung, R. J. Young, Bioorg. Med. Chem. Lett. 17 (2007) 1736-1740.

[7] E. Wagner, K. Al-Kadasi, M. Zimecki, W. Sawka-Dobrowolska, Eur. J. Med. Chem. 43 (2008) 2498-2504.

DOI: https://doi.org/10.1016/j.ejmech.2008.01.035

[8] K. Gorlitzer, S. Herbig, R. D. Walter, Pharmazie. 52 (1997) 670-672.

[9] W. ShenJeu, L. Cheng Tsung, T. Lo Ti, W. Jing Ru, K. Hrogn Huey. W. JihPyang, and L. C. Nan, Eur. J. Med. Chem. 40 (2005) 103-112.

[10] Z. Machon, J. Cieplik, Synthesis. 2 (1986) 142-144.

[11] Z. Machon, J. Cieplik, J. Pharmacol. Pharm. 40 (1988) 201-208.

[12] N. R. Mohamed, M. M. El-Saidi, Y. M. Ali, M. H. Elnagdi, Sci. Pharm. 75 (2007) 9-28.

[13] J. Cieplik, Z. MachoN, M. Zimecki, Z. Wieczorek, Arch. Immunol. Ther. Exp. 41(1993)11-15.

[14] J. Cieplik, Z. MachoN, M. Zimecki, Z. Wieczorek, Farmaco. 50 (1993) 131-132.

[15] J. Pluta, M. Flendrich, J. Cieplik, Boll. Chim. Farm. 135 (1996) 459-464.

[16] Y. A. Mostafa, M. A. Husein, A. A. Radwan, A. H. Kfafy, Arch. Pharm. Res. Soc. Korea. 31 (2008) 279-293.

[17] G. T. Kim, R. J. Ryu, S. Lee Ch, H. Youn, Y. R. Cho, H. Y. Joo, J. Antibio. Jap. Res. (2004) 468-471.

[18] J. Cieplik, J. Pluta, A. Meler, Arch. Pharm. Pharm. Med. Chem. 330 (1997) 237-241.

DOI: https://doi.org/10.1002/ardp.19973300802

[19] N. S. Habib, R. Soliman, A. A. El-Tombary, S. A. El-Hawash, O. G. Shaaban, Arch. Pharm. Res. Soc. Korea. 30 (2007) 1511-1520.

DOI: https://doi.org/10.1007/bf02977319

[20] J. Cieplik, J. Pluta, O. Gubrynowicz, Sci. Pharm. 68 (2000) 333-336.

[21] J. Cieplik , M. Raginia, J. Pluta, O. Gubrynowicz, I. Bryndal, T. Lis, Acta. Pol. Pharm. Drug. Res. 65 (2008) 427-434.

[22] Z. Macho, J. Cieplik, Eur. J. Med. Chem., Chim. Ther. 19 (1984) 359-363.

[23] H. R. Khunt, P. P. Pipaliya, S. M. Ghelani, J. S. Babariya, Y. T. Naliapara, International Letters of Chemistry, Physics and Astronomy 5 (2014) 134-121.

[24] W.P. Hays, C. J. Timmons., Spectrochim. Acta. 24A (1968) 323-334.

[25] C.G. Swain, E. C. Lupton Jr., J. Am. Chem. Soc. 90 (1968) 4328-4337.

[26] R. Ranganathan, R. Arulkumaran, D. Kamalakkannan, G. Vanangamudi, G. Thirunarayanan., IUP J. Chem. 4(2) (2011) 60-70.

[27] K. Sathiyamoorthi, V. Mala, R. Suresh, S. P. Sakthinathan, D. Kamalakkannan, K. Ranganathan, R. Arulkumaran, R. Sundararajan, S. Vijayakumar, G. Vanangamudi, G. Thirunarayanan, International Letters of Chemistry, Physics and Astronomy 7 (2013).

DOI: https://doi.org/10.18052/www.scipress.com/ilcpa.11.77

[28] V. Mala, K. Sathiyamoorthi, S. P. Sakthinathan, D. Kamalakkannan, R. Suresh, G. Vanangamudi, G. Thirunarayanan, Q. Science Connect. (2013) 7, DOI: http: /dx. doi. org/ 10. 5339/ connect. 2013. 7.

DOI: https://doi.org/10.5339/connect.2013.7

[29] S. P. Sakthinathan, R. Suresh, V. Mala, K. Sathiyamoorthi, D. Kamalakkannan, K. Ranganathan, R. Arulkumaran, S. Vijayakumar, R. Sundararajan, G. Vanangamudi, G. Thirunarayanan, International Letters of Chemistry, Physics and Astronomy 6 (2013).

DOI: https://doi.org/10.18052/www.scipress.com/ilcpa.11.77

[30] R. Suresh, D. Kamalakkannan, K. Ranganathan, R. Arulkumaran, R. Sundararajan, S.P. Sakthinathan, S. Vijayakumar, K. Sathiyamoorthi, V. Mala, G. Vanangamudi, K. Thirumurthy, P. Mayavel, G. Thirunarayanan, Spectrochim. Acta Part A., 101 (2013).

DOI: https://doi.org/10.1016/j.saa.2012.09.039

[31] K. Sathiyamoorthi, V. Mala, S.P. Sakthinathan, D. Kamalakkannan, R. Suresh, G. Vanangamudi , G. Thirunarayanan., Spectrochim. Acta Part A, 112 (2013) 245-256.

DOI: https://doi.org/10.1016/j.saa.2013.04.048

[32] P. Janaki, K. G Sekar, G. Thirunarayanan., Organic Chem: An Indian J., 9 (2013) 68-80.

[33] R. Arulkumaran, R. Sundararajan, G. Vanangamudi, M . Subramanian, K. Ravi, V. Sathiyendiran, S. Srinivasan, G. Thirunarayanan., IUP J. Chem., 3 (2010) 82-98.

[34] S. Vijayakumar, R. Arulkumaran, R. Sundararajan, S. P. Sakthinathan, R. Suresh, D. Kamalakkannan, K. Ranganathan, K. Sathiyamoorthi, V. Mala, G. Vanangamudi, G. Thirunarayanan, International Letters of Chemistry, Physics and Astronomy 9 (2013).

DOI: https://doi.org/10.18052/www.scipress.com/ilcpa.11.77

[35] G. Thirunarayanan, K. G. Sekar, International Letters of Chemistry, Physics and Astronomy 17(2)(2014) 193-200.

[36] G. Thirunarayanan, K. G. Sekar, International Letters of Chemistry, Physics and Astronomy 17(1) (2014) 10-20.

[37] G. Thirunarayanan, K.G. Sekar, R. Lakshmi Narayanan, International Letters of Chemistry, Physics and Astronomy 13(1) (2014) 88-94.

[38] P. Mayavel, K. Thirumurthy, S. Dinesh Kumar, G. Thirunarayanan, Q-Science Connect. (2014). DOI: http: /dx. doi. org/10. 5339/connect. 2014. 10.

[39] G. Thirunarayanan, K. G. Sekar, J. Taibah Univ. Sci. 8(2014) 124-136.

[40] V. Sathiyendiran, K. G. Sekar, G. Thirunarayanan, R. Arulkumaran, R. Sundararajan, D. Kamalakkannan, R. Suresh, V. Manikanadan, R. Vijayakumar, G. Vanangamudi, International Letters of Chemistry, Physics and Astronomy 11(1) (2014).

DOI: https://doi.org/10.18052/www.scipress.com/ilcpa.30.33
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