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International Letters of Chemistry, Physics and Astronomy
Volume 36
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Synthesis, Characterization of Biologically Potent Novel Chalcones Bearing Urea, Thiourea and Acetamide Linkages

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Abstract:

Three series of some novel chalcone based urea, thiourea and acetamide derivatives were designed, synthesized and screened for their antimicrobial and antifungal activities. All the synthesized compounds are first reported. The structures of the compounds were elucidated with the aid of elemental analysis and spectral methods including IR, 1H-NMR spectral data. The prepared compounds were evaluated for antibacterial activity against two Gram-positive bacteria (Staphylococcus aureus, Staphylococcus pyogenus), two Gram-negative bacteria (Pseudomonas aeruginosa, Escherichia coli). The title compounds were also investigated for their antifungal activity using the broth micro dilution method. The bioassay results showed that compounds a few compounds showed good to superior in vitro antibacterial and antifungal activity.

Info:

Periodical:
International Letters of Chemistry, Physics and Astronomy (Volume 36)
Pages:
281-294
DOI:
10.18052/www.scipress.com/ILCPA.36.281
Citation:
N. S. Mewada et al., "Synthesis, Characterization of Biologically Potent Novel Chalcones Bearing Urea, Thiourea and Acetamide Linkages", International Letters of Chemistry, Physics and Astronomy, Vol. 36, pp. 281-294, 2014
Online since:
Jul 2014
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