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International Letters of Chemistry, Physics and Astronomy
Volume 36
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Synthesis of Novel 2-Mercapto-4-(p-Aminophenyl Sulphonylamino)-6-(Aryl)-Pyrimidine-5-Carboxamide Derivatives via the Biginelli Reaction

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Abstract:

Series of 2-mercapto-4-(p-aminophenylsulphonylamino)-6-(aryl)-pyrimidine-5-carboxamide Aa-h were synthesized via the biginelli condensation. 2-mercapto-4-amino-6-(aryl)-pyrimidine-5-carboxamide react with p-acetamidophenylsulphonylchloride in the presence of pyridine 2 to form 2-mercapto-4-(p-acetamidophenylsulphonylamino)-6-(aryl)-pyrimidine-5-carboxamide 3. It was treated with diluted HCl under reflux afforded 2-mercapto-4-(p-aminophenylsulphonylamino)-6-(aryl)-pyrimidine-5-carboxamide Aa-h.. The newly synthesized compounds were characterized by elemental analyses, infrared (IR), 1H NMR and 13C NMR spectroscopic investigation.

Info:

Periodical:
International Letters of Chemistry, Physics and Astronomy (Volume 36)
Pages:
168-173
DOI:
10.18052/www.scipress.com/ILCPA.36.168
Citation:
N. H. Bhuva et al., "Synthesis of Novel 2-Mercapto-4-(p-Aminophenyl Sulphonylamino)-6-(Aryl)-Pyrimidine-5-Carboxamide Derivatives via the Biginelli Reaction", International Letters of Chemistry, Physics and Astronomy, Vol. 36, pp. 168-173, 2014
Online since:
Jul 2014
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