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Synthesis, Characterization and Biological Evaluation of 2,5-di-Substituted 1,3,4-Oxadiazole Derivatives

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Abstract:

We have reported some novel 1,3,4-oxadiazole synthesized by conventional method .The reaction of 5-bromothiophene-2-carbohydrazide and different benzoic acid derivatives reflux in toluene using phosphorus oxychloride as a catalyst, yielded a series of 2,5-di-substituted 1,3,4-oxadiazole HM-2a to HM-2t. The newly synthesized 2,5-di-substituted 1,3,4-oxadiazole were purified by column chromatography and characterized by IR, Mass, 1H NMR, 13C NMR spectroscopy and elemental analysis. All synthesized compounds were screened for antimicrobial activity using cup plate method. All the compounds showed moderate to good antimicrobial activity and anti fungal activity.

Info:

Periodical:
International Letters of Chemistry, Physics and Astronomy (Volume 34)
Pages:
48-54
DOI:
10.18052/www.scipress.com/ILCPA.34.48
Citation:
H. Makwana and Y. T. Naliapara, "Synthesis, Characterization and Biological Evaluation of 2,5-di-Substituted 1,3,4-Oxadiazole Derivatives", International Letters of Chemistry, Physics and Astronomy, Vol. 34, pp. 48-54, 2014
Online since:
May 2014
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