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International Letters of Chemistry, Physics and Astronomy
Volume 33

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An Efficient Solid Phase One Port Synthesis of Novel Triazolo[1,5-a]Pyrimidine Derivatives from 4-(4-Aminophenyl)Morpholin-3-One and Evaluation of their Antimicrobial Activity

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Abstract:

A series of novel triazolo[1,5-a]pyrimidine derivatives was synthesized from 5-amino-1,2,4-triazole and biologically active morpholinone amine in excellent yield as promising class of antimicrobial agents. The antimicrobial activities were investigated against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, Staphylococcus pyogen, Candida albicans, Aspergillusniger, Aspergillusclavatus and compared with standard drugs Ampicillin, Chloramphenicol, Norfloxacin and Griseofulvin. All the synthesized compounds were characterized by IR, 1H NMR, 13C and mass spectroscopy. The result of antimicrobial activity data revealed that compound 4f,4g and 4i were found more active against bacterial species and compound 4c, 4d, 4g, 4i and 4jwere found more active against fungal strain, while other compounds shows moderate to law activity against microbes.

Info:

Periodical:
International Letters of Chemistry, Physics and Astronomy (Volume 33)
Pages:
12-21
Citation:
D. R. Prajapati et al., "An Efficient Solid Phase One Port Synthesis of Novel Triazolo[1,5-a]Pyrimidine Derivatives from 4-(4-Aminophenyl)Morpholin-3-One and Evaluation of their Antimicrobial Activity", International Letters of Chemistry, Physics and Astronomy, Vol. 33, pp. 12-21, 2014
Online since:
May 2014
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References:

Fischer G., Adv. Heterocyclic Chemistry 57 (1993) 81.

Shaban M.A.E., Morgan A.E.A., Adv. Heterocyclic Chemistry 77 (2000) 345.

Shaban, M.A.E., Morgan A.E.A., Adv. Heterocyclic Chemistry 73 (2000) 131.

Shaban, M.A.E.; Morgan A.E.A., Adv. Heterocyclic Chemistry 75 (2000) 243.

Ashour H. M., Shaaban O. G., Rizk O. H., El-Ashmawy I. M., Euro. J. Med. Chem. 62 (2013) 341.

Marwaha A., White J., El Mazoun F., Creason S. A., Kokkond S., Buckner F. S., Rathod P. K., J. Med. Chem. 55 (2012) 7425.

Chen Q., Zhu X. L., Liu, et al., Euro. J. Med. Chem. 43 (2008) 595.

Uryu S., Tokuhiro S., Murasugi T., Brain Research 946 (2002) 298.

Zhang N., Semiramis A. K., Thai N., J. Med. Chem. 50 (2007) 319.

Havlicek L., Fuksova K., Krystof V., Bioorg. Med. Chem. 13 (2005) 5399.

Zhao X., Zhao Y., Guo S., Song H., Wang D., Gong P., Molecules 12 (2007) 1136.

Iwona L., Marzena F., Tadeusz M., Tadeusz S., Julia J., Dalton Transactions 42 (2013) 6219.

Yin L., Shuai Z., Zhi-Jun L., Hai-Liang Z., Euro. J. Med. Chem. 64 (2013) 54.

Ashraf H. F., Abd El-Wahab, Pharmaceuticals 5 (2012) 745.

Abdel-Aziem A., Sayed El-Gendy M., Abdelhamid A. O., Euro. J. Chem. 3 (2012) 455.

Khera M. K., Cliffe I. A., Mathur T., Prakash O., Bioorg & Med. Chem. Lett. 21 (2011) 2887.

Fraley M. E., Hoffman W. F., Rubino R. S., Bioorg. Med. Chem. Lett. 12 (2002) 2767.

Antonino L., Ilenia A., Chiara P., Annamaria M., Gaetano D., Maria A. A., Euro. J. Med. Chem. 62 (2013) 416.

Fairfield B. J., Andrew C., Allan J., WO2004108136, (2004).

G. Thirunarayanan, International Letters of Chemistry, Physics and Astronomy 5 (2014) 89-98.

Nirav M. Shah, Hitendra S. Joshi, International Letters of Chemistry, Physics and Astronomy 6 (2014) 56-60.

Piyush B. Vekariya, Jalpa R. Pandya, Vaishali Goswami, Hitendra S. Joshi, International Letters of Chemistry, Physics and Astronomy 7 (2014) 45-52.

Sagar P. Gami, Kalpesh V. Vilapara, Hasmukh R. Khunt, Jayesh S. Babariya, Yogesh T. Naliapara, International Letters of Chemistry, Physics and Astronomy 11(2) (2014) 127-134.

Hasmukh R. Khunt, Piyush P. Pipaliya, Satish M. Ghelani, Jayesh S. Babariya, Yogesh T. Naliapara, International Letters of Chemistry, Physics and Astronomy 12 (2014) 20-25. ( Received 18 April 2014; accepted 25 April 2014 ).

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