Sustain Release Formulation and Evaluation of Ofloxacin Floating Delivery System

Patel, Anand J.; Naik, Deep R.; Raval, Jignesh P.

doi:10.18052/www.scipress.com/ILCPA.31.69

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Sustain Release Formulation and Evaluation of Ofloxacin Floating Delivery System

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Abstract:

Floating tablets has been accepted as a process to achieve controlled drug delivery by prolonging the residence time of the dosage form at the site of absorption, thereby improving and enhancing the bioavailability of drug. The objective of present study outlines the development and characterization the floating drug delivery system of Ofloxacin to enhance its bioavailability and therapeutic efficacy, using different grades of polymer along with effervescent agent sodium bicarbonate and citric acid. Ofloxacin is a synthetic chemotherapeutic second-generation antibiotic of the fluoroquinolone class. Different tablet formulations were formulated by wet granulation technique and were evaluated for physical parameters like Tablet Thickness, Hardness, % Friability, Weight variation, Content uniformity, In vitro buoyancy, Swelling index, In vitro dissolution study and drug release mechanisms. As the concentration of the polymer in the formulations increased the release of drug decreased. Hence it was considered as suitable candidate for formulation as floating drug delivery system. Different kinetic models were applied to drug release data in order to evaluate release mechanisms and kinetics. The optimized formula F4 showed better sustained drug release with good floating properties and fitted best to be Korsmeyer-Peppas model with R2 value of 0.9575. As the n value for the Korsmeyer- Peppas model was found be more than 0.5 it follows Non-Fickian diffusion mechanism. FTIR result showed that there is no drug excipients interaction.

Info:

Periodical:

International Letters of Chemistry, Physics and Astronomy (Volume 31)

Pages:

69-83

DOI:

https://doi.org/10.18052/www.scipress.com/ILCPA.31.69

Citation:

A. J. Patel et al., "Sustain Release Formulation and Evaluation of Ofloxacin Floating Delivery System", International Letters of Chemistry, Physics and Astronomy, Vol. 31, pp. 69-83, 2014

Online since:

March 2014

Authors:

Anand J. Patel, Deep R. Naik, Jignesh P. Raval

Keywords:

Controlled Release, Ethyl Cellulose, Floating Drug Delivery System, Ofloxacin, Xanthum Gum

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Creative Commons Attribution 4.0 International License

References:

Brahma, S.; Kwon, K., J. Chem. Pharm. Sci., 63 (2000) 235-259.

Cargill, R.; Caldwell, L.; Engle, K.; Fix, J.; Porter, P.; Gardner, C., Pharm. Res. 5 (1998) 533-536.

Gangadharappa, V.; Pramod, M.; Shiva, G. Ind. J Pharm. Edu. Res. 41(4) (2007) 295303.

Streubel, A.; Siepmann, J.; Bodmeier, R., Expert Opinion Drug Delivery 3(2) (2007) 217-233.

Santus, G.; Lazzarini, G.; Bottoni, G., Eur. J Pharm. Biopharm. 44 (1997) 39-52.

Deshpande, A.; Rhodes, T.; Shah, H.; Malick, W., Drug Deliv. Ind. Pharm. 22 (1996) 531-539.

Deshpande, A.; Rhodes, T.; Shah, H.; Malick, W., Pharm. Res. 14 (1997) 815-819.

Menon, A.; Ritshel, A.; Sakr, A., J Pharm. Sci. 83 (1998) 239-245.

Whitehead, L.; Fell, T.; Collett, H.; Sharma, L.; Smith, M., J Control Release, 55 (1998) 3-12.

Patel, M.; Patel, M.; Pandya, M.; Jogani, D., Indian J Pharm. Sci. 69(6) (2007) 763- 767.

Janardhan, D.; Joginapally, S.; Bharat, V.; Subramaniam, P., Int. J. Pharm. Sci. Nanotech. 1 (2009) 428-434.

Padmavathy, J.; Saravanan, D.; Rajesh, D., Int. J Pharm. Pharm. Sci. 3(1) (2011) 170- 173.

V. J. Faldu, P. K. Talpara, N. H. Bhuva, P. R. Vachharajani, V. H. Shah, International Letters of Chemistry, Physics and Astronomy 6 (2014) 26-32.

Vipul C. Kotadiya, Denish J. Viradiya, Bharat H. Baria, Jayendra S. Kanzariya, Rajesh Kakadiya, Anamik Shah, International Letters of Chemistry, Physics and Astronomy 11(3) (2014) 265-276.

Boldhane, P.; Kuchekar, S., Curr. Drug Delivery 6(5) (2009) 477-485.

Jagdale, C.; Agavekar, J.; Pandya, V.; Kuchekar, S.; Chabukswar, R., AAPS 10(3) (2009) 1071-1079.

Jaimini, M.; Rana, C.; Tanwar, S., Curr. Drug Delivery 4 (2007) 51-55.

Lachman, L.; Liberman, H.A.; Kanig, J.L., The Theory and Practice of Industrial Pharmacy, 3rd ed, Mumbai, Varghese publishing house, (1990) 296-302.

Patil, P.; Rao, S.; Kulkarni, S.; Basavaraj.; Surpur, C.; Ammanage, A., Asian J Res. Pharm. Sci., 1(1) (2011) 17-22.

Rosa, M.; Zia, H.; Rhodes, T., Int. J Pharm. 105 (1994) 65-67.

Lalla, K.; Gurnancy, A., Indian Drugs 39 (2002) 270-276.

Veerareddy, P.; Bajjuri, S.; Sanka, S.; Jukanti, R.; Bandari, S.; Ajmeru, V.; Rao, A., Stamford J. Pharm. Sci. 4(1) (2011) 09-18.

Donbrow, M.; Samuelov, Y., J. Pharm. Pharmacology 32 (1961) 463-470.

Merchant, A.; Shoaib, M.; Tazeen, J.; Yousuf I., AAPS 7(3) (2006) 78-86.

Higuchi, T., J. Pharm. Sci. 52 (2006) 1145-1149.

Korsmeyer R., Gurny R., Docler E., Buri P., Peppas A., Int. J. Pharmacy 15 (1983) 2535. ( Received 23 March 2014; accepted 28 March 2014 ).

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