Subscribe

Subscribe to our Newsletter and get informed about new publication regulary and special discounts for subscribers!

ILCPA > Volume 31 > Sustain Release Formulation and Evaluation of...
< Back to Volume

Sustain Release Formulation and Evaluation of Ofloxacin Floating Delivery System

Full Text PDF

Abstract:

Floating tablets has been accepted as a process to achieve controlled drug delivery by prolonging the residence time of the dosage form at the site of absorption, thereby improving and enhancing the bioavailability of drug. The objective of present study outlines the development and characterization the floating drug delivery system of Ofloxacin to enhance its bioavailability and therapeutic efficacy, using different grades of polymer along with effervescent agent sodium bicarbonate and citric acid. Ofloxacin is a synthetic chemotherapeutic second-generation antibiotic of the fluoroquinolone class. Different tablet formulations were formulated by wet granulation technique and were evaluated for physical parameters like Tablet Thickness, Hardness, % Friability, Weight variation, Content uniformity, In vitro buoyancy, Swelling index, In vitro dissolution study and drug release mechanisms. As the concentration of the polymer in the formulations increased the release of drug decreased. Hence it was considered as suitable candidate for formulation as floating drug delivery system. Different kinetic models were applied to drug release data in order to evaluate release mechanisms and kinetics. The optimized formula F4 showed better sustained drug release with good floating properties and fitted best to be Korsmeyer-Peppas model with R2 value of 0.9575. As the n value for the Korsmeyer- Peppas model was found be more than 0.5 it follows Non-Fickian diffusion mechanism. FTIR result showed that there is no drug excipients interaction.

Info:

Periodical:
International Letters of Chemistry, Physics and Astronomy (Volume 31)
Pages:
69-83
DOI:
https://doi.org/10.18052/www.scipress.com/ILCPA.31.69
Citation:
A. J. Patel et al., "Sustain Release Formulation and Evaluation of Ofloxacin Floating Delivery System", International Letters of Chemistry, Physics and Astronomy, Vol. 31, pp. 69-83, 2014
Online since:
Mar 2014
Authors:
Anand J. Patel, Deep R. Naik, Jignesh P. Raval
Keywords:
Controlled Release, Ethyl Cellulose, Floating Drug Delivery System, Ofloxacin, Xanthum Gum
Export:
RIS, BibTeX, Text
Distribution:
Open Access

Creative Commons License
This work is licensed under a
Creative Commons Attribution 4.0 International License

References:

Brahma, S.; Kwon, K., J. Chem. Pharm. Sci., 63 (2000) 235-259.

Cargill, R.; Caldwell, L.; Engle, K.; Fix, J.; Porter, P.; Gardner, C., Pharm. Res. 5 (1998) 533-536.

Gangadharappa, V.; Pramod, M.; Shiva, G. Ind. J Pharm. Edu. Res. 41(4) (2007) 295303.

Streubel, A.; Siepmann, J.; Bodmeier, R., Expert Opinion Drug Delivery 3(2) (2007) 217-233.

Santus, G.; Lazzarini, G.; Bottoni, G., Eur. J Pharm. Biopharm. 44 (1997) 39-52.

Deshpande, A.; Rhodes, T.; Shah, H.; Malick, W., Drug Deliv. Ind. Pharm. 22 (1996) 531-539.

Deshpande, A.; Rhodes, T.; Shah, H.; Malick, W., Pharm. Res. 14 (1997) 815-819.

Menon, A.; Ritshel, A.; Sakr, A., J Pharm. Sci. 83 (1998) 239-245.

Whitehead, L.; Fell, T.; Collett, H.; Sharma, L.; Smith, M., J Control Release, 55 (1998) 3-12.

Patel, M.; Patel, M.; Pandya, M.; Jogani, D., Indian J Pharm. Sci. 69(6) (2007) 763- 767.

Janardhan, D.; Joginapally, S.; Bharat, V.; Subramaniam, P., Int. J. Pharm. Sci. Nanotech. 1 (2009) 428-434.

Padmavathy, J.; Saravanan, D.; Rajesh, D., Int. J Pharm. Pharm. Sci. 3(1) (2011) 170- 173.

V. J. Faldu, P. K. Talpara, N. H. Bhuva, P. R. Vachharajani, V. H. Shah, International Letters of Chemistry, Physics and Astronomy 6 (2014) 26-32.

Vipul C. Kotadiya, Denish J. Viradiya, Bharat H. Baria, Jayendra S. Kanzariya, Rajesh Kakadiya, Anamik Shah, International Letters of Chemistry, Physics and Astronomy 11(3) (2014) 265-276.

Boldhane, P.; Kuchekar, S., Curr. Drug Delivery 6(5) (2009) 477-485.

Jagdale, C.; Agavekar, J.; Pandya, V.; Kuchekar, S.; Chabukswar, R., AAPS 10(3) (2009) 1071-1079.

Jaimini, M.; Rana, C.; Tanwar, S., Curr. Drug Delivery 4 (2007) 51-55.

Lachman, L.; Liberman, H.A.; Kanig, J.L., The Theory and Practice of Industrial Pharmacy, 3rd ed, Mumbai, Varghese publishing house, (1990) 296-302.

Patil, P.; Rao, S.; Kulkarni, S.; Basavaraj.; Surpur, C.; Ammanage, A., Asian J Res. Pharm. Sci., 1(1) (2011) 17-22.

Rosa, M.; Zia, H.; Rhodes, T., Int. J Pharm. 105 (1994) 65-67.

Lalla, K.; Gurnancy, A., Indian Drugs 39 (2002) 270-276.

Veerareddy, P.; Bajjuri, S.; Sanka, S.; Jukanti, R.; Bandari, S.; Ajmeru, V.; Rao, A., Stamford J. Pharm. Sci. 4(1) (2011) 09-18.

Donbrow, M.; Samuelov, Y., J. Pharm. Pharmacology 32 (1961) 463-470.

Merchant, A.; Shoaib, M.; Tazeen, J.; Yousuf I., AAPS 7(3) (2006) 78-86.

Higuchi, T., J. Pharm. Sci. 52 (2006) 1145-1149.

Korsmeyer R., Gurny R., Docler E., Buri P., Peppas A., Int. J. Pharmacy 15 (1983) 2535. ( Received 23 March 2014; accepted 28 March 2014 ).

Show More Hide