The literature review reveal that [1,4]-oxazine derivatives represent one of the most active classes of compounds possessing wide spectrum of biodynamic activities and use as potent therapeutic agents. In the present work, a series of Schiff base of 2-(2,3-dihydro-2-oxonaphtho[2,1-b][1,4]oxazin-1-yl)acetohydrazide, 5a-5j has been synthesized using 1-aminonaphthalen-2-ol. Various aromatic aldehyde were react with carbohydrazide 4 in the presence of acid to produce the 2-oxonaphtho[2,1-b][1,4]oxazin Schiff base derivatives with good yields. All synthesized compounds were characterized by IR, NMR and Mass spectrometry analysis.
International Letters of Chemistry, Physics and Astronomy (Volume 31)
P. Chovatiya et al., "Synthesis and Characterization of some New Schiff Bases of 2-Oxonaphtho[2,1-b][1,4]Oxazine", International Letters of Chemistry, Physics and Astronomy, Vol. 31, pp. 26-30, 2014