An eco-friendly and efficient one-pot synthesis of penta-substituted pyrrole derivatives via a four-component reaction of maldrum’s acid, arylglyoxal monohydrate, dimethyl but-2-yne-dioate and amines under catalyst-free conditions in an environmentally friendly medium is described. The simple experimental procedure, catalyst-free reaction conditions, short period of conversion, and excellent yields are the advantages of the present method. Good chemical yields have been achieved without the need for chromatography and recrystallization or other purification methods.
International Letters of Chemistry, Physics and Astronomy (Volume 30)
D. J. Viradiya et al., "Highly Efficient and Eco-Friendly One-Pot Synthesis of Penta Substitute Pyrrole Derivatives under Catalyst-Free Conditions", International Letters of Chemistry, Physics and Astronomy, Vol. 30, pp. 257-264, 2014