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International Letters of Chemistry, Physics and Astronomy
ILCPA Volume 30

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Synthesis and Antimicrobial Activity of Coumarinyl Schiff Base Derivatives

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We have reported some novel N’-[(1)-ethylidene]-2-(6-methyl-2-oxo-2H-chromen-4-yl) acetohydrazide synthesized by conventional method. The reaction of 2-(6-methyl-2-oxo-2H-chromen-4-yl)acetohydrazide with substituted benzaldehyde in methanol as a solvent yielded a series of (7a-l). The structures of all synthesized compounds are well characterized by Mass, FT-IR, 1H NMR, 13C NMR and elemental analysis. Moreover, all synthesized compounds were screened for In Vitro antimicrobial activity against the gram positive (Staphylococcus aureus, Bacilluas subtilis) and gram negative (Escherichia coli, P. aeruginosa, K. pneunonae, Enterobacter) bacterial strain. In which some the compounds show potential inhibition against the test organisms.


International Letters of Chemistry, Physics and Astronomy (Volume 30)
A. Mishra et al., "Synthesis and Antimicrobial Activity of Coumarinyl Schiff Base Derivatives", International Letters of Chemistry, Physics and Astronomy, Vol. 30, pp. 193-201, 2014
Online since:
March 2014

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[2] D. Belkhir-Talbi, M. Makhloufi-Chebli, S. Terrachet-Bouaziz, D. Hikem-Oukacha, N. Ghemmit, L. Ismaili, A. M.S Silva, M. Hamdi, "Synthesis, characterization, theoretical studies, ADMET and drug-Likeness analysis: Electrochemical and biological activities of metal complexes of 3-(2-hydroxybenzoyl)-2H-chromen-2-one", Journal of Molecular Structure, 2018