Synthesis and Characterization of Novel (E)-1-(Aylideneamino)-6-(4-Methoxyphenyl)-2-Oxo-4-(Trifluoromethyl)-1,2-Dihydropyridine-3-Carbonitrile Derivatives

We have described simple facile method for the synthesis of Novel (E)-1-(aylideneamino)-6-(4-methoxyphenyl)-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile derivatives by using 1,3-diketone as synthon. All the synthesized compounds were characterized by IR, Mass and 1H NMR spectroscopy.


INTRODUCTION
The pyridine skeleton is of great importance to chemists as well as to biologists as it is found in a large variety of naturally occurring compounds and also in clinically useful molecules having diverse biological activities. The pyridine ring systems have emerged as integral backbones of over 7000 existing drugs [1,2] . The pyridine ring is also an integral part of anticancer and anti-inflammatory agents [3] .
In association with those, Pyridone and their derivatives play an essential role in several biological processes and have considerable chemical and pharmacological importance [4][5][6] . 2-Pyridones represent a unique class of pharmacophore, which are observed in various therapeutic agents [7] and antibiotics [8] . These heterocycles attracted attention because of their applications as bioactive compounds for example as a promising class of HIV-1 nonnucleoside reverse transcriptase inhibitors (NNRTIs) [9] ,as antibacterial [10] , antifungal [11] , sedative [12] and cardiotonic agents [13] . Moreover, such derivatives have recently become important due to their structural similarity to nucleosides [14] . Also, 2-pyridones were used as ligands for the late 3d-metals [15] .
They are also versatile precursors for the construction of complex natural products [16] , pyridines [17] and larger pyridone systems such as those found in the nitroguanidine insecticide Imidacloprid [18] and subtype selective GABAA receptor agonists [19] . Consequently, methodologies for the preparation of pyridones have attracted much attention from both industry and academia. 3-Cyano-2-Pyridones are much interest in the anticancer activity of these compounds owing to different types of biological targets they might interfere with for this effect to occur e.g. PDE3, PIM1 Kinase, and Surviving protein.

RESULT AND DISCUSSION
In the first step it is very convenient to use sodium methoxide/sodiumethoxide. Here the use of sodium hydride also gives the better result. In step-2 the cyclization rapidly exist if electron donating group present on phenyl ring and further more the presence of electronwithdrawing group at another end also beneficial. The cyclisedpyridone ring with N-amino functionality undergoes nucleophilic addition on carbonyl of various aromatic aldehydes results in to the formation of substituted pyridone derivatives (3a-l). The Various aldehydes used are listed in Table 1 with their M.P.

EXPERIMENTAL
Thin-layer chromatography was accomplished on 0.2 mm precoated plates of silica gel G60 F 254 (Merck). Visualization was made with UV light (254 and 365 nm) or with an iodine vapor. IR spectra were recorded on a FTIR-8400 spectrophotometer using DRS prob. 1 H (400 MHz) and 13 C (100 MHz) NMR spectra were recorded on a Bruker AVANCE II spectrometer in CDCl 3 .
Chemical shifts are expressed in δ ppm downfield from TMS as an internal standard. Mass spectra were determined using direct inlet probe on a GCMS-QP 2010 mass spectrometer (Shimadzu). Solvents were evaporated with a BUCHI rotary evaporator. Melting points were measured in open capillaries and are uncorrected.

CONCLUSION
Pyridone compounds when it bearing different functional group it is very important in its class. We have reported here the novel trifluoromethylated N-arylidine amino pyridone library which can be utilised in the field of organo-pharmaceutical chemistry.