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International Letters of Chemistry, Physics and Astronomy
Volume 30

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Synthesis and Characterization of Novel (E)-1-(Aylideneamino)-6-(4-Methoxyphenyl)-2-Oxo-4-(Trifluoromethyl)-1,2-Dihydropyridine-3-Carbonitrile Derivatives
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Synthesis and Characterization of Novel (E)-1-(Aylideneamino)-6-(4-Methoxyphenyl)-2-Oxo-4-(Trifluoromethyl)-1,2-Dihydropyridine-3-Carbonitrile Derivatives

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Abstract:

We have described simple facile method for the synthesis of Novel (E)-1-(aylideneamino)-6-(4-methoxyphenyl)-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile derivatives by using 1,3-diketone as synthon. All the synthesized compounds were characterized by IR, Mass and 1H NMR spectroscopy.

Info:

Periodical:
International Letters of Chemistry, Physics and Astronomy (Volume 30)
Pages:
185-192
DOI:
https://doi.org/10.18052/www.scipress.com/ILCPA.30.185
Citation:
H. R. Khunt et al., "Synthesis and Characterization of Novel (E)-1-(Aylideneamino)-6-(4-Methoxyphenyl)-2-Oxo-4-(Trifluoromethyl)-1,2-Dihydropyridine-3-Carbonitrile Derivatives", International Letters of Chemistry, Physics and Astronomy, Vol. 30, pp. 185-192, 2014
Online since:
March 2014
Authors:
Hasmukh R. Khunt, Jayesh S. Babariya, Chandni D. Dedakiya, Charmi A. Maniar, Yogesh T. Naliapara
Keywords:
1,3-Diketone, 2-Cyanoacetohydrazide, N-Amino Pyridine
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Distribution:
Open Access

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References:

Li, A. H.; Moro, S.; Forsyth, N.; Melman, N.; Ji, X. D.; Jacobsen, K. A. J. Med. Chem. 42 (1999) 706.

Vacher, B.; Bonnand, B.; Funes, F.; Jubault, N.; Koek, W.; Assie, M. B.; Cosi, C.; Kleven, M. J. Med. Chem. 42 (1999) 1648.

(a) Son, J. K.; Zhao, L. X.; Basnet, A.; Thapa, P.; Karki, R.; Na, Y.; Jahng, Y.; Jeong, T. C.; Jeong, B. S.; Lee, C. S.; Lee, E. S., Eur. J. Med. Chem. 43 (2008) 675. (b) Amr, A. G.; Abdulla, M. M.; Bioorg. Med. Chem. 14 (2006) 4341.

Choi, W.; Houpis, I. N.; Charchil, H. R. O.; Molina, A.; Lynch, J. E.; Volante, R. P.; Reider, P. J.; King, A. O. Tetrahedron 36 (1995) 4571.

Bhupathy, M.; Conlon, D. A.; Wells, K. M.; Wells, M.; Nolson, J. R.; Reider, P. J.; Rossen, K.; Sager, J.W.; Volante, R. P. J. Heterocyclic Chem. 32 (1995) 1283.

Kappe, O. C.; Kappe, T. Monatshefte fur Chemie 120 (1989) 1095.

(a) Saiki, A. Y. C.; Shen, L. L.; Chen, C. M.; Baranowski, J.; Lerner, C. G. Antimicrob. Agents Chemother. 43 (1999) 1574; (b) Li, Q.; Mitscher, L. A.; Shen, L. L. Med. Res. Rev. (2000) 231.

Brickner, S. Chem. Ind. (1997) 131.

(a) Goldman, M. E.; Nunberg, J. H.; O'Brien, J. A.; Quintero, J. C.; Schleif, W. A.; Freund, K. F.; Gaul, S. L.; Saari, W. S.; Wai, J. S.; Hoffman, J. M.; Anderson, P. S.; Hupe, D. J.; Emini, E. A.; Stern, A. M. Proc. Natl. Acad. Sci. 88 (1991).

(a) Li, Q.; Mitscher, L. A.; Shen, L. L. Med. Res. Rev. 20 (2000) 231; (b) Holzgrabe, U. Pharm. Unserer Zeit. 30 (2001) 446.

Gupta, A. K.; Plott, T. Int. J. Dermatol. 43 (2004) 3.

Collins, I.; Moyes, C.; Davey, W.; Rowley, M.; Bromidge, F.; Quirk, K.; Atack, J.; McKernan, R.; Thompson, S. A.; Wafford, K.; Dawson, G.; Pike, A.; Sohal, B.; Tsou, N.; Bull, R.; Castro, J. J. Med. Chem. 45 (2002) 1887.

(a) Endoh, M.; Hori, M. Exp. Opin. Pharmacother. 7 (2006).

Sollogoub, M.; Fox, K. R.; Powers, V. E. C.; Brown, T., Tetrahedron Lett. 43 (2002).

Parsons, S.; Winpenny, R. E. P. Acc. Chem. Res. 30 (1997) 89.

Kawato, Y.; Terasawa, H. Prog. Med. Chem. 34 (1997) 69.

Murray, T.; Zimmerman, S. Tetrahedron Lett. 36 (1995) 7627.

Werbitzky, O.; Studer, P. U.S. Patent 6, 022, 974, Feb 9, (2000).

Harrison, T.; Moyes, C. R.; Nadin, A.; Owens, A. P.; Lewis, R. T. PCT WO 98/50384. ( Received 07 March 2014; accepted 12 March 2014 ).

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