Paper Titles in Periodical
International Letters of Chemistry, Physics and Astronomy
Volume 30

Subscribe

Subscribe to our Newsletter and get informed about new publication regulary and special discounts for subscribers!

ILCPA > Volume 30 > Synthesis and Characterization of Novel...
Synthesis and Characterization of Novel (E)-1-(Aylideneamino)-6-(4-Methoxyphenyl)-2-Oxo-4-(Trifluoromethyl)-1,2-Dihydropyridine-3-Carbonitrile Derivatives
< Back to Volume

Synthesis and Characterization of Novel (E)-1-(Aylideneamino)-6-(4-Methoxyphenyl)-2-Oxo-4-(Trifluoromethyl)-1,2-Dihydropyridine-3-Carbonitrile Derivatives

Full Text PDF

Abstract:

We have described simple facile method for the synthesis of Novel (E)-1-(aylideneamino)-6-(4-methoxyphenyl)-2-oxo-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile derivatives by using 1,3-diketone as synthon. All the synthesized compounds were characterized by IR, Mass and 1H NMR spectroscopy.

Info:

Periodical:
International Letters of Chemistry, Physics and Astronomy (Volume 30)
Pages:
185-192
DOI:
https://doi.org/10.18052/www.scipress.com/ILCPA.30.185
Citation:
H. R. Khunt et al., "Synthesis and Characterization of Novel (E)-1-(Aylideneamino)-6-(4-Methoxyphenyl)-2-Oxo-4-(Trifluoromethyl)-1,2-Dihydropyridine-3-Carbonitrile Derivatives", International Letters of Chemistry, Physics and Astronomy, Vol. 30, pp. 185-192, 2014
Online since:
March 2014
Authors:
Hasmukh R. Khunt, Jayesh S. Babariya, Chandni D. Dedakiya, Charmi A. Maniar, Yogesh T. Naliapara
Keywords:
1,3-Diketone, 2-Cyanoacetohydrazide, N-Amino Pyridine
Export:
RIS, BibTeX, Text
Distribution:
Open Access

Creative Commons License
This work is licensed under a
Creative Commons Attribution 4.0 International License

References:

Li, A. H.; Moro, S.; Forsyth, N.; Melman, N.; Ji, X. D.; Jacobsen, K. A. J. Med. Chem. 42 (1999) 706.

Vacher, B.; Bonnand, B.; Funes, F.; Jubault, N.; Koek, W.; Assie, M. B.; Cosi, C.; Kleven, M. J. Med. Chem. 42 (1999) 1648.

(a) Son, J. K.; Zhao, L. X.; Basnet, A.; Thapa, P.; Karki, R.; Na, Y.; Jahng, Y.; Jeong, T. C.; Jeong, B. S.; Lee, C. S.; Lee, E. S., Eur. J. Med. Chem. 43 (2008) 675. (b) Amr, A. G.; Abdulla, M. M.; Bioorg. Med. Chem. 14 (2006) 4341.

Choi, W.; Houpis, I. N.; Charchil, H. R. O.; Molina, A.; Lynch, J. E.; Volante, R. P.; Reider, P. J.; King, A. O. Tetrahedron 36 (1995) 4571.

Bhupathy, M.; Conlon, D. A.; Wells, K. M.; Wells, M.; Nolson, J. R.; Reider, P. J.; Rossen, K.; Sager, J.W.; Volante, R. P. J. Heterocyclic Chem. 32 (1995) 1283.

Kappe, O. C.; Kappe, T. Monatshefte fur Chemie 120 (1989) 1095.

(a) Saiki, A. Y. C.; Shen, L. L.; Chen, C. M.; Baranowski, J.; Lerner, C. G. Antimicrob. Agents Chemother. 43 (1999) 1574; (b) Li, Q.; Mitscher, L. A.; Shen, L. L. Med. Res. Rev. (2000) 231.

Brickner, S. Chem. Ind. (1997) 131.

(a) Goldman, M. E.; Nunberg, J. H.; O'Brien, J. A.; Quintero, J. C.; Schleif, W. A.; Freund, K. F.; Gaul, S. L.; Saari, W. S.; Wai, J. S.; Hoffman, J. M.; Anderson, P. S.; Hupe, D. J.; Emini, E. A.; Stern, A. M. Proc. Natl. Acad. Sci. 88 (1991).

(a) Li, Q.; Mitscher, L. A.; Shen, L. L. Med. Res. Rev. 20 (2000) 231; (b) Holzgrabe, U. Pharm. Unserer Zeit. 30 (2001) 446.

Gupta, A. K.; Plott, T. Int. J. Dermatol. 43 (2004) 3.

Collins, I.; Moyes, C.; Davey, W.; Rowley, M.; Bromidge, F.; Quirk, K.; Atack, J.; McKernan, R.; Thompson, S. A.; Wafford, K.; Dawson, G.; Pike, A.; Sohal, B.; Tsou, N.; Bull, R.; Castro, J. J. Med. Chem. 45 (2002) 1887.

(a) Endoh, M.; Hori, M. Exp. Opin. Pharmacother. 7 (2006).

Sollogoub, M.; Fox, K. R.; Powers, V. E. C.; Brown, T., Tetrahedron Lett. 43 (2002).

Parsons, S.; Winpenny, R. E. P. Acc. Chem. Res. 30 (1997) 89.

Kawato, Y.; Terasawa, H. Prog. Med. Chem. 34 (1997) 69.

Murray, T.; Zimmerman, S. Tetrahedron Lett. 36 (1995) 7627.

Werbitzky, O.; Studer, P. U.S. Patent 6, 022, 974, Feb 9, (2000).

Harrison, T.; Moyes, C. R.; Nadin, A.; Owens, A. P.; Lewis, R. T. PCT WO 98/50384. ( Received 07 March 2014; accepted 12 March 2014 ).

Show More Hide
Cited By:

[1] M. Salem, M. Helel, M. Gouda, Y. Ammar, M. El-Gaby, "Overview on the synthetic routes to nicotine nitriles", Synthetic Communications, Vol. 48, p. 345, 2018

DOI: https://doi.org/10.1080/00397911.2017.1394468