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International Letters of Chemistry, Physics and Astronomy
Volume 30

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Synthesis and Antimicrobal Activities of some Novel Triazolo[1,5-a]Pyrimidine Derivatives

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Abstract:

A convenient synthesis of substituted 1,2,4-triazolo[1,5-a]pyrimidine was carried out by the reaction of various ketene dithioacetals with 5-amino 1,2,4-triazole in methanol in presence of sodium methoxide. The newly synthesized compound were characterized by 1H NMR, 13C NMR, IR, MS, elemental analysis and screened for their antimicrobial activity against various strains of bacteria and fungi.

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Periodical:
International Letters of Chemistry, Physics and Astronomy (Volume 30)
Pages:
127-134
Citation:
S. P. Gami et al., "Synthesis and Antimicrobal Activities of some Novel Triazolo[1,5-a]Pyrimidine Derivatives", International Letters of Chemistry, Physics and Astronomy, Vol. 30, pp. 127-134, 2014
Online since:
March 2014
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Cited By:

[1] M. Raslan, O. Omran, "Synthesis and Reactivity of Enaminones: Synthesis of Some 1,3,4-Thiadiazole Linked to Pyrazole, Pyridine, Benzimidazolopyrimidine, Pyrazolopyrimidine, Pyrazolotriazine and Triazolotriazine Derivatives", Journal of Heterocyclic Chemistry, Vol. 53, p. 1121, 2016

DOI: https://doi.org/10.1002/jhet.2359

[2] E. Paronikyan, S. Dashyan, R. Paronikyan, I. Dzhagatspanyan, I. Nazaryan, A. Akopyan, N. Minasyan, "Synthesis and neurotropic activity of the derivatives of fused triazolo[4,3-c]- and triazolo[1,5-c]pyrimidines", Russian Journal of Bioorganic Chemistry, Vol. 43, p. 595, 2017

DOI: https://doi.org/10.1134/S1068162017040070

[3] A. Hassan, M. Sarg, A. Bayoumi, M. El-Deeb, "Synthesis and Anticancer Evaluation of Some Novel 5-Amino[1,2,4]Triazole Derivatives", Journal of Heterocyclic Chemistry, 2018

DOI: https://doi.org/10.1002/jhet.3184

[4] S. Lahmidi, E. Anouar, M. El Hafi, M. Boulhaoua, A. Ejjoumamany, M. El Jemli, E. Essassi, J. Mague, "Synthesis, X-Ray, spectroscopic characterization, DFT and antioxidant activity of 1,2,4-triazolo[1,5-a]pyrimidine derivatives", Journal of Molecular Structure, 2018

DOI: https://doi.org/10.1016/j.molstruc.2018.09.046
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