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ILCPA > Volume 29 > Synthesis and Antimicrobial Activity of Some New...
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Synthesis and Antimicrobial Activity of Some New Imidazolinone Derivatives Containing Benzimidazole

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Abstract:

In this study some new o-benzimidazol-2'-yl-benzamido-p'-benzamido-2-phenyl-4-substituted phenyl-5-oxo-Imidazolines 3a-3j were synthesized. To synthesized target molecules we used various substituted oxazolone derivatives, synthesized from substituted benzaldehyde with hippuric acid. Substituted oxazolones 2a-2j were reacted with carbohydrazide derivative of benzimidazole 1 in presence of pyridine as base to obtained substituted imidazolinone derivatives. All synthesized compounds were characterized by IR, 1H NMR, elemental analysis and further supported by mass spectroscopy. All synthesized compounds were screened for their antimicrobial activity against gram positive and gram negative bacteria which showed moderate to good activity. All compounds showing good to moderate active against fungal strain as compare to standard drug.

Info:

Periodical:
International Letters of Chemistry, Physics and Astronomy (Volume 29)
Pages:
74-80
DOI:
10.18052/www.scipress.com/ILCPA.29.74
Citation:
P. Mehta et al., "Synthesis and Antimicrobial Activity of Some New Imidazolinone Derivatives Containing Benzimidazole", International Letters of Chemistry, Physics and Astronomy, Vol. 29, pp. 74-80, 2014
Online since:
Mar 2014
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