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Analgesic and Anti-Inflammatory Activities of some Transition Metal Schiff Base Complexes

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Analgesic and anti-inflammatory activities of four transition metal complexes of a Schiff base derived from salicylaldehyde and glycine, viz. [N-salicylideneglycinato diaqua cobalt(II) dimer] (SGCo)2, [N-salicylideneglycinato-di-aqua-nickel(ll)dimer] (SGN)2, [N-salicylideneglycinato-aqua-copper(II)] (SGC) and [N-salicylideneglycinato diaqua zinc(II) dimer] (SGZ)2 were studied in swiss albino mice. 10 mg/kg (p.o) dose for each compound were selected throughout the research work. The analgesic activity was determined by acetic acid induced writhing and tail immersion methods. All such data were compared with standard drugs at the dose of 10 mg/kg (p.o. The anti-inflammatory activity of the test compounds was determined by the carragenan induced mice paw edema inhibition method.). Analgesic and anti-inflammatory activities of the test compounds at 10 mg/kg (p.o.) were quite comparable to those of standard drugs at 10 mg/kg (p.o.). All these compounds can be considered as potent analgesic and anti-inflammatory agents.


International Letters of Chemistry, Physics and Astronomy (Volume 27)
M. Jesmin et al., "Analgesic and Anti-Inflammatory Activities of some Transition Metal Schiff Base Complexes", International Letters of Chemistry, Physics and Astronomy, Vol. 27, pp. 64-72, 2014
Online since:
Feb 2014

Sosa S., Balicet M. J., Arvigo R., Esposito R. G., Pizza C. Altinier G. A., J. Ethanopharmacol 8 (2002) 211-215.

Kumar V., Abbas A. K., Fausto N. (Eds. ). Robbins and Cotran pathologic basis of disease, 7th edition, Elsevier Saunders, Philadelphia, Pennsylvania, 2004, pp.47-86.

Pandeya S. N., Sriram D., Nath G., DEclereq E., Eur J Phar Sci. 9(1) (1999) 25-32.

Chen M., Phodes J., J Mol Med 74 (1996) 497-504.

Islam M. R., Mirza A. M., Huda Q. M. N. , Khan B. R., J Ban Chem Soc 2 (1989) 8795.

Sakiyan I., Logoglu E., Arslan S., Sari N., Sakian N., Biometals 17 (2004) 115-120.

Molla B. S., Rao B. S., Shridhara K., Akberali P. M., Pharmacol 55 (2000) 338-344.

Islam M. N., Shahriar S. M. S., Islam M. K., Jesmin M., Ali M. M., Khanam J. A., International Letters of Chemistry, Physics and Astronomy 5 (2013) 12-20.

Ali M. M., Jesmin M., Islam M. N., Shahriar S. M. S., Habib M. R., Islam M. F., Khanam J. A., ACGC Chem Res Comm 23 (2009) 13-22.

Elementary Practical Organic Chemistry Part 2: Qualitative Organic Analysis; 2nd ed., Vogel AI. 1974, 118.

Gupta M., et al., J Ethnopharmacol 98 (2005) 267-273.

Toma W, at al., J Ethnopharmacol 85 (2003) 19-23.

Ghule R. S., Venkatnarayanan R., Thakare S. P., Jain H., Ghule P. R., J Adv. Phar Educ. Res. 1 (2011) 45-51.

Kaushik D., Kumar A., Kaushik P., Rana A. C., Analgesic and antiinflammatory activity of Pinus roxburghii Sarg 2012; doi: 10. 1155/2012/245431.

Chapman C. R., Casey K. I., Dubner R., Foley K. M., Gracely R. H., Reading A. E., Pain 22 (1985) 1-31.

Elisabetsky E., Amador T. A., Albuquerque R. R., Nunes D. S., Cavalho A. C. T., J Ethnopharmacol 48 (1995) 77-83.

Pal S., Sen T., Chaudhuri A. K. M., J Pharm Pharmacol 51 (1999) 313-318.

Ahmed F., Hossain M. H., Rahman A. A., Shahid I. Z., J Ori Pharm Exp Med 6 (2006) 344-348.

Ribeiro R.A., et al., Eur J Pharmacol 387 (2000) 111-118.

Voilley N., Curr Drug Targets Inflamm Allergy 3 (2004) 71-79.

Hossain M. M., Ali M. S., Saha A., Alimuzzaman M., Dhaka Univ J Pharm Sci. 5 (2006) 67-69.

Adzu B., Amos S., Kapu S. D., Gamaniel K. S., J Ethnopharmacol 84 (2003) 169-174.

Hirose K., Jyoyama H., Kojima Y., Arzneim ittelf Forsch/Drug Res 34 (1984) 280-286.

Vogel H. G., Vogel W. H., Drug Discovery and Evaluation - Pharmacological Assays. Springer-Verlag, Berlin Heidelberg 1997; 1231.

Bose U., Gunasekaran K., Bala V., Rahman A. A., J Pharmacol Toxicol 5 (2010) 222228. ( Received 27 January 2014; accepted 02 February 2014 ).

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