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ILCPA > Volume 27 > Synthesis, Characterization and Biological...
Synthesis, Characterization and Biological Evaluation of 6-Substituted-2-(Substituted-Phenyl)-Quinoline Derivatives Bearing 4-Amino-1,2,4-Triazole-3-Thiol Ring at C-4 Position
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Synthesis, Characterization and Biological Evaluation of 6-Substituted-2-(Substituted-Phenyl)-Quinoline Derivatives Bearing 4-Amino-1,2,4-Triazole-3-Thiol Ring at C-4 Position

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Abstract:

Quinoline derivatives represent one of the most active classes of compounds possesses wide spectrum biodynamic activities and use as potent therapeutic agents. In this research work, a synthesis, characterization and biological evaluation of 6-substituted-2-(substituted-phenyl)-quinoline derivatives bearing 4-amino-1,2,4-triazole-3-thiol ring at C-4 position is described. The synthesis of quinoline derivatives is carried out by the reaction of substituted quinoline-4-carbohydrazides with a mixture of carbon disulphide and potassium hydroxide which further react with hydrazine hydrate to give final compounds. All of these compounds were screened for their in vitro antimicrobial assay against gram (+ve), gram (-ve) bacteria and fungi activity compared with standard drugs viz., Ampicilin, Chloramphenicol, Ciprofloxacin, Norfloxacin, Griseofulvin and Nystatin at different concentrations.

Info:

Periodical:
International Letters of Chemistry, Physics and Astronomy (Volume 27)
Pages:
30-37
DOI:
https://doi.org/10.18052/www.scipress.com/ILCPA.27.30
Citation:
R.G. Vaghasiya et al., "Synthesis, Characterization and Biological Evaluation of 6-Substituted-2-(Substituted-Phenyl)-Quinoline Derivatives Bearing 4-Amino-1,2,4-Triazole-3-Thiol Ring at C-4 Position", International Letters of Chemistry, Physics and Astronomy, Vol. 27, pp. 30-37, 2014
Online since:
February 2014
Authors:
R.G. Vaghasiya, H.B. Ghodasara, P.R. Vachharajani, Viresh H. Shah
Keywords:
4-Amino-1,2,4-Triazole-3-Thiol, Antimicrobial Assay, Quinolines, Therapeutic Agents
Export:
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Distribution:
Open Access

Creative Commons License
This work is licensed under a
Creative Commons Attribution 4.0 International License

References:

P. Donald, P. Van Helden, N Engl J Med 360 (2009) 2393-2395.

R. Tripathi, N. Tewari, N. Dwivedi, V. Tiwari, Med Res Rev 25 (2005) 93-131.

Y. Zhang, K. Post-Martens S. Denkin, Drug Discov Today 11 (2006) 21-27.

http: /www. who. int, (2007).

J. Polanski, F. Zouhiri, L. Jeanson, D. Desmaële, J. d'Angelo, J. Mouscadet, R. Gieleciak, J. Gasteiger, M. Le Bret, Journal of medicinal chemistry 45(21) (2002) 4647-4654.

Schnute, E. Mark, PTC int Appl. Wo 01 98 (2001) 275.

F. Salem, J. Drug Res 12 (1980) 101.

B. Chaudhari, M. Chapdeline, G. Hostetler, L. Kemp, J. McCauley, PTC int Appl. Wo 02 36 (2000) 586.

M. Chapdeline, J. McCauley, PTC int Appl. Wo 02 36 (2000) 576.

P. Stocks, K. Raynes, P. Bray, B. Kevin Park, P. O'Neill, S. Ward, J. Med. Chem. 45 (2002) 4975.

R. Ridley, W. Hofheinz, H. Matile, C. Jaquet, A. Dorn, R. Masciadri, S. Jolidon, W. Richter, A. Guenzi, M. Girometta, Antimicrobial agents and chemotherapy 40(8) (1996) 1846-1854.

G. Lesher, E. Froelich, M. Gruet, J. Baily, and R. Brudage, J. med. pharm. Chem 5 (1962) 1068.

Holzgrabe, U, Steinert, M, Die Pharmazie 56 (11) (2001) 850.

K. Fang, Y. Chen, J. Sheu, T. Wang, C. Tzeng, Journal of medicinal chemistry 43 (20) (2000) 3809-3812.

Y. Chen, K. Fang, J. Sheu, S. Hsu, C. Tzeng, Journal of medicinal chemistry 44 (2001) 2371.

Belal, F, Al-Majed, A, Al-Obaid, A, Talanta 50(4) (1999) 765-786.

H. Bayrak, A. Demirbas, S. A. Karaoglu, N. Demirbas, European journal of medicinal chemistry 44(3) (2009) 1057-1066.

A. Hasan, N. F. Thomas, S. Gapil, Molecules, 16(2) (2011) 1297-1309.

Z. Khiati, A. A. Othman, B. Guessas, South African Journal of Chemistry 60 (2007).

Rahul R. Tripathi, Ratnamala P. Sonawane, International Letters of Chemistry, Physics and Astronomy 10(2) (2013) 119-125.

Mallikarjun S. Yadawe, Shrishila N. Unki, Sangamesh A. Patil, International Letters of Chemistry, Physics and Astronomy 12 (2013) 94-104.

G. Thirunarayanan, International Letters of Chemistry, Physics and Astronomy 5 (2014) 89-98.

V. J. Faldu, P. K. Talpara, N. H. Bhuva, P. R. Vachharajani, V. H. Shah, International Letters of Chemistry, Physics and Astronomy 6 (2014) 26-32.

Piyush B. Vekariya, Jalpa R. Pandya, Vaishali Goswami, Hitendra S. Joshi, International Letters of Chemistry, Physics and Astronomy 7 (2014) 45-52. ( Received 22 January 2014; accepted 27 January 2014 ).

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