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Antibacterial, Antifungal, Anti-Oxidant, Anti-Inflammatory and Anti-Hypertensive Activities of N-Chloropyrazinamide

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N-chloropyrazinamide was prepared by the chlorination of pyrazinamide using trichloroisocyanuric acid. The experimental results ascertained that the tested N-chloropyrazinamide showed good antimicrobial activities when compared to standard drug. It was found that N-chloropyrazinamide at different concentrations exhibited significant dose dependent anti-oxidant, anti-inflammatory and anti-hypertensive activity.


International Letters of Chemistry, Physics and Astronomy (Volume 26)
S. P. Vaijayanthi and N. Mathiyalagan, "Antibacterial, Antifungal, Anti-Oxidant, Anti-Inflammatory and Anti-Hypertensive Activities of N-Chloropyrazinamide", International Letters of Chemistry, Physics and Astronomy, Vol. 26, pp. 1-8, 2014
Online since:
January 2014

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[1] R. Zaki, M. Abdul-Malik, S. Saber, S. Radwan, A. El-Dean, "A convenient synthesis, reactions and biological evaluation of novel pyrazolo[3,4-b]selenolo[3,2-e]pyrazine heterocycles as potential anticancer and antimicrobial agents", Medicinal Chemistry Research, 2020


[2] P. Mech, M. Makowski, A. Kawiak, A. Chylewska, "When biomolecules meet 2-hydrazinopyrazine: from theory through experiment to molecular levels using a wide spectrum of techniques", RSC Advances, Vol. 10, p. 40673, 2020


[3] M. Abd ul‐Malik, A. Kamal El‐Dean, S. Radwan, R. Zaki, " Facile synthesis and antimicrobial evaluations of some novel pyrazolo[3,4‐ b ]selenolo[3,2‐ e ]pyrazines and their related heterocycles ", Journal of Heterocyclic Chemistry, 2021