Antibacterial, Antifungal, Anti-Oxidant, Anti-Inflammatory and Anti-Hypertensive Activities of N-Chloropyrazinamide

Vaijayanthi, S. Parimala; Mathiyalagan, N.

doi:10.18052/www.scipress.com/ILCPA.26.1

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Antibacterial, Antifungal, Anti-Oxidant, Anti-Inflammatory and Anti-Hypertensive Activities of N-Chloropyrazinamide

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Abstract:

N-chloropyrazinamide was prepared by the chlorination of pyrazinamide using trichloroisocyanuric acid. The experimental results ascertained that the tested N-chloropyrazinamide showed good antimicrobial activities when compared to standard drug. It was found that N-chloropyrazinamide at different concentrations exhibited significant dose dependent anti-oxidant, anti-inflammatory and anti-hypertensive activity.

Info:

Periodical:

International Letters of Chemistry, Physics and Astronomy (Volume 26)

Pages:

1-8

DOI:

https://doi.org/10.18052/www.scipress.com/ILCPA.26.1

Citation:

S. P. Vaijayanthi and N. Mathiyalagan, "Antibacterial, Antifungal, Anti-Oxidant, Anti-Inflammatory and Anti-Hypertensive Activities of N-Chloropyrazinamide", International Letters of Chemistry, Physics and Astronomy, Vol. 26, pp. 1-8, 2014

Online since:

January 2014

Authors:

S. Parimala Vaijayanthi, N. Mathiyalagan

Keywords:

Antibacterial Activity, Antifungal Activity, Antihypertensive Activity, Anti-Inflammatory, Anti-Oxidant Activity, N-Chloropyrazinamide

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Creative Commons Attribution 4.0 International License

References:

[1] Michael H. Cynamon, Sally P. Klemens, Tso Sheng Chou, Rayomand H. Gimi, John T. Welch, Journal of Medicinal Chemistry 35 (1992) 1212-1215.

DOI: https://doi.org/10.1021/jm00085a007

[2] Setsuko Yamamoto, Ichiro Toida, Nanao Watanabe, Toshikazu Ura, Antimicrobial Agents and Chemotherapy 39(9) (1995) 2088-(2091).

DOI: https://doi.org/10.1128/aac.39.9.2088

[3] Veronika Opletalova, Jiri Hartl, Asmita Patel, Karel Palat Jr, Vladimir Buchta, Farmaco 57 (2002) 135-144.

DOI: https://doi.org/10.1016/s0014-827x(01)01187-9

[4] Martin Dolezal, Lenka Tumova, Diana Kesetovicova, Jiri Tuma, Katarina Kraloya, Molecules 12(12) (2007) 2589-2598.

DOI: https://doi.org/10.3390/12122589

[5] Martin Dolezal, Lukas Palek, Jarmila Vinsova, Vladimir Buchta, Josef Jampilek, Katarina Kraloya, Molecules 11(4) (2006) 242-256.

DOI: https://doi.org/10.3390/11040242

[6] A. W. Cuthbert, J. M. Edwardson, Journal of Pharmacy and Pharmacology 31(6) (1979) 382-386.

[7] B. A. Ellsworth, et. al., Bioorganic Medicinal Chemistry Letters 17(14) (2007) 3978-3982.

[8] Martin Dolezal, Jan Zitko, Diana Kesetovicova, Jiri Kunes, Michaela Svobodova, Molecules 14(10) (2009) 4180-4189.

DOI: https://doi.org/10.3390/molecules14104180

[9] Lenka Tumova, Jiri Tuma, Klara Megusar, Marin Dolezal, Molecules 15(1) (2010) 331-340.

DOI: https://doi.org/10.3390/molecules15010331

[10] M. Dolezal, J. Zitko, Z. Osicka, J. Kunes, M. Vejsova, V. Buchta, J. Dohnal, J. Jampilek, K. Kralova, Molecules 15(12) (2010) 8567-8581.

DOI: https://doi.org/10.3390/molecules15128567

[11] Lenka Tumova, Jiri Tuma, Martin Dolezal, Molecules 16(11) (2011) 9142-9152.

DOI: https://doi.org/10.3390/molecules16119142

[12] S. Suzuki, A. Inoue, Chemical Abstracts 113 (1990) 218276t.

[13] T. Sado, A. Inoue, Chemical Abstracts 113 (1990) 78422k.

[14] Talaat Ibrahim El-Emary, Journal of Chinese Chemical Society 53(2) (2006) 391-401.

[15] H. S. El-Kashef, T. I. El-Emary, M. Gasquet, P. Timon-David, J. Maldonado, P. Vanelle, Pharmazie 55(8) (2000) 572-576.

DOI: https://doi.org/10.1002/chin.200047151

[16] S. Parimala Vaijayanthi, N. Mathiyalagan, International Journal of Research in Organic Chemistry 2(3) (2012) 13-15.

[17] S. K. Ling, T. Tanaka, I. Kouno, Biological & Pharmaceutical Bulletin 26(3) (2003) 352-356.

[18] S. Kumar, D. Kumar, Manjusha, K. Saroha, N. Singh, B. Vashishta, Acta Pharmaceutica 58 (2008) 215-220.

[19] V. K. Jimsheena, Analytical Chemistry 81 (2009) 9388-9394.

[20] Nigel M. Hooper, Anthony J. Turner, Biochemical Journal 241 (1987) 625-633. ( Received 07 January 2014; accepted 12 January 2014 ).

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Cited By:

[1] R. Zaki, M. Abdul-Malik, S. Saber, S. Radwan, A. El-Dean, "A convenient synthesis, reactions and biological evaluation of novel pyrazolo[3,4-b]selenolo[3,2-e]pyrazine heterocycles as potential anticancer and antimicrobial agents", Medicinal Chemistry Research, 2020

DOI: https://doi.org/10.1007/s00044-020-02635-z

[2] P. Mech, M. Makowski, A. Kawiak, A. Chylewska, "When biomolecules meet 2-hydrazinopyrazine: from theory through experiment to molecular levels using a wide spectrum of techniques", RSC Advances, Vol. 10, p. 40673, 2020

DOI: https://doi.org/10.1039/D0RA06239A