A series containing eleven benzofuranyl flavonols have been prepared by cyclization of 3-hydroxybenzofuranyl chalcones with 30% hydrogen peroxide in the presence of sodium bicarbonate. The synthesized flavonols were characterized by their physical constants, analytical and spectroscopic data. The infrared spectral νOH, CO stretches(cm-1), NMR chemical shifts of OH, CO(δ, ppm) of these flavonols were assigned and correlated with Hammett substituent constants, F and R parameters using single and multi linear regression analysis. From the results of statistical analyses, the effects of substituents on the above group frequencies were discussed.
International Letters of Chemistry, Physics and Astronomy (Volume 25)
G. Thirunarayanan and K.G. Sekar, "Hammett Spectral Correlations in Benzofuranyl Flavonols", International Letters of Chemistry, Physics and Astronomy, Vol. 25, pp. 39-47, 2014