Synthesis, Characterization and Biological Evaluation of some Newer 5-[6-Chloro/Fluor/Nitro-2-(p-Chloro/Fluoro/Methyl Phenyl)-Quinolin-4-yl]-1,3,4-Oxadiazole-2-Thiols

Faldu, V.J.; Talpara, P.K.; Bhuva, N.H.; Vachharajani, P.R.; Shah, Viresh H.

doi:10.18052/www.scipress.com/ILCPA.25.26

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Synthesis, Characterization and Biological Evaluation of some Newer 5-[6-Chloro/Fluor/Nitro-2-(p-Chloro/Fluoro/Methyl Phenyl)-Quinolin-4-yl]-1,3,4-Oxadiazole-2-Thiols

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Abstract:

Recent study shows that quinolines represent one of the most active classes of compounds possesses wide spectrum biodynamic activities and use as potent therapeutic agents. In present research work, 5-[6-chloro/fluoro/nitro-2-(p-chloro/fluoro/methyl phenyl)-quinolin-4-yl]-1,3,4-oxadiazole-2-thiols have been synthesized by condensation of substituted quinoline-4-carbohydrazides and mixture of carbon disulphide and potassium hydroxide. All of these compounds were screened for their in vitro anti microbial assay against gram (+ve), gram (-ve) bacteria and fungi activity compared with standard drugs viz., Ampicilin, Chloramphenicol, Ciprofloxacin, Norfloxacin, Griseofulvin and Nystatin at different concentrations.

Info:

Periodical:

International Letters of Chemistry, Physics and Astronomy (Volume 25)

Pages:

26-32

DOI:

https://doi.org/10.18052/www.scipress.com/ILCPA.25.26

Citation:

V.J. Faldu et al., "Synthesis, Characterization and Biological Evaluation of some Newer 5-[6-Chloro/Fluor/Nitro-2-(p-Chloro/Fluoro/Methyl Phenyl)-Quinolin-4-yl]-1,3,4-Oxadiazole-2-Thiols", International Letters of Chemistry, Physics and Astronomy, Vol. 25, pp. 26-32, 2014

Online since:

January 2014

Authors:

V.J. Faldu, P.K. Talpara, N.H. Bhuva, P.R. Vachharajani, Viresh H. Shah

Keywords:

1,3,4-Oxadiazole-2-Thiols, Anti-Microbial Assay, Quinolines, Therapeutic Agents

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References:

P. Donald, P. Van Helden, N Engl J Med 360 (2009) 2393-2395.

R. Tripathi, N. Tewari, N. Dwivedi, V. Tiwari, Med Res Rev 25 (2005) 93-131.

Y. Zhang, K. Post-Martens, S. Denkin, Drug Discov Today 11 (2006) 21-27.

http: /www. who. int, (2007).

F. Salem, J. Drug Res 12 (1980) 101.

P. Stocks, K. Raynes, P. Bray, B. Kevin Park, P. O'Neill, S. Ward, J. Med. Chem. 45 (2002) 4975.

R. Ridley, W. Hofheinz, H. Matile, C. Jaquet, A. Dorn, R. Masciadri, S. Jolidon, W. Richter, A. Guenzi, M. Girometta, Antimicrobial agents and chemotherapy 40(8) (1996) 1846-1854.

J. Polanski, F. Zouhiri, L. Jeanson, D. Desmaële, J. d'Angelo, J. Mouscadet, R. Gieleciak, J. Gasteiger, M. Le Bret, Journal of medicinal chemistry 45(21) (2002) 4647-4654.

Schnute E. Mark, PTC int Appl. Wo 01 98 (2001) 275.

B. Chaudhari, M. Chapdeline, G. Hostetler, L. Kemp, J. McCauley, PTC int Appl. Wo 02 36 (2000) 586.

M. Chapdeline, J. McCauley, PTC int Appl. Wo 02 36 (2000) 576.

G. Lesher, E. Froelich, M. Gruet, J. Baily, R. Brudage, J. Med. Pharm. Chem 5 (1962) 1068.

Holzgrabe U., Steinert M., Die Pharmazie 56 (11) (2001) 850.

K. Fang, Y. Chen, J. Sheu, T. Wang, C. Tzeng, Journal of Medicinal Chemistry 43 (20) (2000) 3809-3812.

Y. Chen, K. Fang, J. Sheu, S. Hsu, C. Tzeng, Journal of Medicinal Chemistry 44 (2001) 2371.

Belal F., Al-Majed A., Al-Obaid A., Talanta 50(4) (1999) 765-786.

N. Gularman, S. Rollas, H. Erdeniz, M. Kiraz, Journal of Pharmaceutical Sciences 26 (2001) 1.

A. Foroumadi, M. Danstalab, M. Mahamoudian, M. Falahati, N. Nateghian, N. Shahsavarani, A. Shafiee, Pharm. Pharmacol. Commun 4 (1998) 95.

N. Habib, R. Soliman, F. Ashour, M. El-Taiebi, Die Pharmazie 52 (1997) 746.

A. Trivedi, V. Bhuva, B. Dholariya, D. Dodiya, V. Kataria, V. Shah, Bioorganic & Medicinal Chemistry Letters 20 (2010) 6100.

G. Alamelumangai, N. Santhi, International Letters of Chemistry, Physics and Astronomy 5 (2014) 124-133. ( Received 24 December 2013; accepted 29 December 2013 ).

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