Synthesis, Characterization and Biological Evaluation of some Newer 5-[6-Chloro/Fluor/Nitro-2-(p-Chloro/Fluoro/Methyl Phenyl)-Quinolin-4-yl]-1,3,4-Oxadiazole-2-Thiols

Faldu, V.J.; Talpara, P.K.; Bhuva, N.H.; Vachharajani, P.R.; Shah, Viresh H.

doi:10.18052/www.scipress.com/ILCPA.25.26

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Synthesis, Characterization and Biological Evaluation of some Newer 5-[6-Chloro/Fluor/Nitro-2-(p-Chloro/Fluoro/Methyl Phenyl)-Quinolin-4-yl]-1,3,4-Oxadiazole-2-Thiols

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Abstract:

Recent study shows that quinolines represent one of the most active classes of compounds possesses wide spectrum biodynamic activities and use as potent therapeutic agents. In present research work, 5-[6-chloro/fluoro/nitro-2-(p-chloro/fluoro/methyl phenyl)-quinolin-4-yl]-1,3,4-oxadiazole-2-thiols have been synthesized by condensation of substituted quinoline-4-carbohydrazides and mixture of carbon disulphide and potassium hydroxide. All of these compounds were screened for their in vitro anti microbial assay against gram (+ve), gram (-ve) bacteria and fungi activity compared with standard drugs viz., Ampicilin, Chloramphenicol, Ciprofloxacin, Norfloxacin, Griseofulvin and Nystatin at different concentrations.

Info:

Periodical:

International Letters of Chemistry, Physics and Astronomy (Volume 25)

Pages:

26-32

DOI:

https://doi.org/10.18052/www.scipress.com/ILCPA.25.26

Citation:

V.J. Faldu et al., "Synthesis, Characterization and Biological Evaluation of some Newer 5-[6-Chloro/Fluor/Nitro-2-(p-Chloro/Fluoro/Methyl Phenyl)-Quinolin-4-yl]-1,3,4-Oxadiazole-2-Thiols", International Letters of Chemistry, Physics and Astronomy, Vol. 25, pp. 26-32, 2014

Online since:

January 2014

Authors:

V.J. Faldu, P.K. Talpara, N.H. Bhuva, P.R. Vachharajani, Viresh H. Shah

Keywords:

1,3,4-Oxadiazole-2-Thiols, Anti-Microbial Assay, Quinolines, Therapeutic Agents

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Creative Commons Attribution 4.0 International License

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