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Assessment of Substituent Effects and Antimicrobial Activities of some 2ʹ,5ʹ-Dimethyl Phenyl Chalcones

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Abstract:

Some 2ʹ,5ʹ-dimethyl phenyl chalcones have been synthesized by Crossed-Aldol condensation between 2,5-dimethyl acetophenone and various substituted benzaldehydes using catalytic amount of sodium hydroxide and ethanol. The yields of the chalcones are more than 93%. The purities of these chalcones have been checked by their physical constants, UV, IR, NMR and MASS spectral data. The spectral data of these chalcones have been correlated with Hammett sigma constants, F and R parameters using single and multi-linear regression analysis. From the results of statistical analysis, the effects of substituents on the spectral group frequencies have been discussed. The anti-microbial activities of these chalcones have been evaluated using Bauer-Kirby method

Info:

Periodical:
International Letters of Chemistry, Physics and Astronomy (Volume 24)
Pages:
99-123
DOI:
https://doi.org/10.18052/www.scipress.com/ILCPA.24.99
Citation:
S. J. Joseph et al., "Assessment of Substituent Effects and Antimicrobial Activities of some 2ʹ,5ʹ-Dimethyl Phenyl Chalcones", International Letters of Chemistry, Physics and Astronomy, Vol. 24, pp. 99-123, 2014
Online since:
Dec 2013
Authors:
S. John Joseph, D. Kamalakkannan, R. Arulkumaran, S.P. Sakthinathan, R. Suresh, R. Sundararajan, S. Vijayakumar, K. Ranganathan, Ganesan Vanangamudi, Ganesamoorthy Thirunarayanan
Keywords:
Antimicrobial Activities, IR Spectra, NMR Spectra, Substituent Effects, Substituted Styryl 2ʹ,5ʹ-Dimethyl Phenyl Chalcones, UV Spectra
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Distribution:
Open Access

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This work is licensed under a
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