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Solvent-Free Synthesis and Assessment of Substituent Effects from IR & NMR Spectra of some Substituted Benzylidene-5-Ethyl-1,3,4-Thiadiazole-2-Amines

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Abstract:

A series containing ten titled compounds were synthesized by SiO2:H3PO4 catalyzed solvent-free condensation of substituted benzaldehydes and 2-amino-5-ethyl-1,3,4-thiadiazole under microwave irradiation. The yields of prepared amines are more than 90%. The synthesized amines were characterized by their physical constants and spectroscopic data reported in literature earlier for known compounds. The assigned spectral group frequencies such as infrared νC=N, C-S-C, N-N (cm-1) and NMR chemical shifts (δ, ppm) of CH, C=N have been correlated with Hammett substituent constants, F and R parameters using single and multi-linear regression analysis. From the results of statistical analyses, the effects of substituent on the above spectral data have been discussed.

Info:

Periodical:
International Letters of Chemistry, Physics and Astronomy (Volume 24)
Pages:
89-98
DOI:
10.18052/www.scipress.com/ILCPA.24.89
Citation:
G. Thirunarayanan "Solvent-Free Synthesis and Assessment of Substituent Effects from IR & NMR Spectra of some Substituted Benzylidene-5-Ethyl-1,3,4-Thiadiazole-2-Amines", International Letters of Chemistry, Physics and Astronomy, Vol. 24, pp. 89-98, 2014
Online since:
Dec 2013
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