A series of 2,4-dimethoxy phenyl chalcones have been synthesized by Crossed-Aldol condensation of 2,4-dimethoxy phenyl and various substituted benzaldehydes. The purities of these chalcones have been checked by their physical constants, UV, IR, NMR and MASS spectral data. The spectral data of these chalcones have been correlated with Hammett sigma constants, F and R parameters using single and multi-linear regression analysis. From the results of statistical analysis, the effects of substituents on the spectral group frequencies have been discussed. The anti-microbial activities of these chalcones have been evaluated using Bauer-Kirby method.
International Letters of Chemistry, Physics and Astronomy (Volume 23)
S. John Joseph et al., "Spectral Correlation Analysis and Antimicrobial Activities of some 2,4-Dimethoxy Phenyl Chalcones", International Letters of Chemistry, Physics and Astronomy, Vol. 23, pp. 48-65, 2014