Subscribe to our Newsletter and get informed about new publication regulary and special discounts for subscribers!

ILCPA > ILCPA Volume 18 > Determination of Kinetic Parameters of...
< Back to Volume

Determination of Kinetic Parameters of Decomposition of Tetrahydropyrimidine Derivatives

Full Text PDF


Some new tetrahydropyrimidine derivatives have been synthesized and their structural determination was done by IR, NMR and mass spectral data. Thermal analysis of these synthesized dihydropyrimidinthiones has been carried out by TGA and DSC techniques. From the thermograms, various kinetic parameters such as order of degradation (n), energy of activation (E), frequency factor (A) and entropy change (ΔS) have been evaluated. Further, thermal stability of tetrahydropyrimidine have been determined which is found to depend on the type of substituent present in the compounds.


International Letters of Chemistry, Physics and Astronomy (Volume 18)
K. Bhesaniya et al., "Determination of Kinetic Parameters of Decomposition of Tetrahydropyrimidine Derivatives", International Letters of Chemistry, Physics and Astronomy, Vol. 18, pp. 23-32, 2013
Online since:
September 2013

Mashkovskii, D.; Medicinals [in Russian], 12th ed., Meditsina, Moscow 1993, Part 1, p.736; 1993, Part 2, p.688.

Nikolaeva, B.; (ed. ), Medicinal Products from Foreign Firms in Russia [in Russian], Astrafarmservis, Moscow, (1993), p.720.

Bahekar, S.; Shinde, D.; Bioorganic and Medicinal Chemistry Letters 14(7) (2004) 17331736.

Mokale, S.; Shinde, S.; Elgire, R.; Sangshetti, J. and Shinde, D.; Bioorganic and Medicinal Chemistry Letters 20(15) (2010) 4424-4426.

Tozkoparan, B.; Ertan, M.; Kelicen, P., Demirdamar, R.; Farmaco. 54(9) (1999) 588-593.

Arora, N.; Pandeya, S.; International Journal of Pharmaceutical Sciences and Research 11(1) (2011) 48-52.

Linsheng, L.; Guibao, Z.; Chuanlin, Y.; Qun, Z. and Nana, C.; Faming Zhuanli Shenqing (2011), CN 102228461 A 20111102.

Li, Baoqiu; Li, Lingzi; Ji, Gao.; Faming Zhuanli Shenqing (2011), CN 102274238 A 20111214.

Ji-Xin, Y.; Xiao-Qing, C.; Di-Mei, C., and Mao-Lin, H.; Chinese Journal of Chemistry 25(3) (2007) 417-421.

Weinhardt, K.; Wallach, M.B.; and Marx, M.; Journal of Medicinal Chemistry 28(6) (1985) 694-698.

Champaneri, H.R.; Modi, S.R.; and Naik, H.B.; Asian Journal of Chemistry 6(3) (1994) 737-738.

Satyavathi, K.; Naga Ravi, K.T.; Bhoja, R.P. and Sharmila, M.; Asian Journal of Chemistry 22(7) (2010) 5182-5186.

Basavaraja, H. S.; Basavaraj, P.; Vijaykumar, M.; Hussain, M. M. and Chidananda, B. N.; Indian journal of heterocylic 20(3) (2011) 237-240.

D. Giron, Journal of pharmaceutical and biomedical analysis 4(6) (1986) 755-770.

Show More Hide
Cited By:
This article has no citations.