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Solubility of a Pharmacological Intermediate Drug Isatin in Different Solvents at Various Temperatures

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Abstract:

The solubility of isatin in different solvents was studied by a gravimetrical method from (298.15 to 318.15) K under atmospheric pressure and the solubility data were correlated against temperature. The solvents selected for the present study are: water, methanol, ethanol, 1-butanol, dichloromethane, dichloroethane, chloroform and carbon tetra chloride. Among chlorinated solvents, solubility is observed to be maximum in 1, 2-dichloroethane and minimum in dichloromethane whereas in alcohols, maximum solubility is observed in methanol. In water, solubility is found to be minimum. Further, some thermodynamic parameters such as Gibb’s energy (ΔGsol), heat of solution (ΔHsol) and entropy of solution (ΔSsol) have also been evaluated.

Info:

Periodical:
International Letters of Chemistry, Physics and Astronomy (Volume 17)
Pages:
36-46
DOI:
https://doi.org/10.18052/www.scipress.com/ILCPA.17.36
Citation:
S. Baluja et al., "Solubility of a Pharmacological Intermediate Drug Isatin in Different Solvents at Various Temperatures", International Letters of Chemistry, Physics and Astronomy, Vol. 17, pp. 36-46, 2013
Online since:
Sep 2013
Authors:
Shipra Baluja, Rahul Bhalodia, Mehul Bhatt, Nayan Vekariya, Ravi Gajera
Keywords:
Isatin, Solubility, Thermodynamic Parameters
Export:
RIS, BibTeX, Text
Distribution:
Open Access

Creative Commons License
This work is licensed under a
Creative Commons Attribution 4.0 International License

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