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Solubility of a Pharmacological Intermediate Drug Isatin in Different Solvents at Various Temperatures

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The solubility of isatin in different solvents was studied by a gravimetrical method from (298.15 to 318.15) K under atmospheric pressure and the solubility data were correlated against temperature. The solvents selected for the present study are: water, methanol, ethanol, 1-butanol, dichloromethane, dichloroethane, chloroform and carbon tetra chloride. Among chlorinated solvents, solubility is observed to be maximum in 1, 2-dichloroethane and minimum in dichloromethane whereas in alcohols, maximum solubility is observed in methanol. In water, solubility is found to be minimum. Further, some thermodynamic parameters such as Gibb’s energy (ΔGsol), heat of solution (ΔHsol) and entropy of solution (ΔSsol) have also been evaluated.


International Letters of Chemistry, Physics and Astronomy (Volume 17)
S. Baluja et al., "Solubility of a Pharmacological Intermediate Drug Isatin in Different Solvents at Various Temperatures", International Letters of Chemistry, Physics and Astronomy, Vol. 17, pp. 36-46, 2013
Online since:
September 2013

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[1] F. Shakeel, N. Haq, F. Alanazi, I. Alsarra, "Thermodynamics of solubility of isatin in (PEG 400+water) mixed solvent systems at T=(298.15 to 338.15)K", The Journal of Chemical Thermodynamics, Vol. 82, p. 156, 2015


[2] F. Shakeel, N. Haq, M. Iqbal, F. Alanazi, I. Alsarra, "Measurement, Correlation, and Thermodynamics of Solubility of Isatin in Nine Different Green Solvents at (298.15 to 338.15) K", Journal of Chemical & Engineering Data, Vol. 60, p. 801, 2015


[3] F. Shakeel, N. Haq, M. Salem-Bekhit, "Thermodynamics of solubility of isatin in Carbitol+water mixed solvent systems at different temperatures", Journal of Molecular Liquids, Vol. 207, p. 274, 2015


[4] A. Henao, A. Johnston, E. Guàrdia, S. McLain, L. Pardo, "On the positional and orientational order of water and methanol around indole: a study on the microscopic origin of solubility", Physical Chemistry Chemical Physics, Vol. 18, p. 23006, 2016


[5] J. Montoya-Aguilera, J. Horne, M. Hinks, L. Fleming, V. Perraud, P. Lin, A. Laskin, J. Laskin, D. Dabdub, S. Nizkorodov, "Secondary organic aerosol from atmospheric photooxidation of indole", Atmospheric Chemistry and Physics, Vol. 17, p. 11605, 2017

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