Kinetics of Oxidation of Amino Acids by a Newly Synthesized Oxidant, N-Chloropyrazinamide in Aqueous Acetic Acid Medium

Vaijayanthi, S. Parimala; Mathiyalagan, N.

doi:10.18052/www.scipress.com/ILCPA.16.1

ILCPA > ILCPA Volume 16 > Kinetics of Oxidation of Amino Acids by a Newly...

< Back to Volume

Kinetics of Oxidation of Amino Acids by a Newly Synthesized Oxidant, N-Chloropyrazinamide in Aqueous Acetic Acid Medium

Full Text PDF

Abstract:

The kinetics of oxidation of amino acids namely, alanine, glycine, leucine, phenyl alanine and valine by N-chloropyrazinamide (NCPZA) in aqueous acetic acid medium in the presence of hydrochloric acid have been investigated. The observed rate of oxidation is first order in [NCPZA], [H+] and [Clˉ]. The order with respect to [amino acid] is zero. The rate of oxidation increases with increase in the percentage of acetic acid. The reaction rate increases slightly with increase in ionic strength, while retards with addition of pyrazinamide. Arrhenius and thermodynamic activation parameters have been evaluated from Arrhenius plot by studying the reaction at different temperatures. A most probable reaction mechanism has been proposed and an appropriate rate law is deduced toaccount for the observed kinetic data.

Info:

Periodical:

International Letters of Chemistry, Physics and Astronomy (Volume 16)

Pages:

1-8

DOI:

https://doi.org/10.18052/www.scipress.com/ILCPA.16.1

Citation:

S. P. Vaijayanthi and N. Mathiyalagan, "Kinetics of Oxidation of Amino Acids by a Newly Synthesized Oxidant, N-Chloropyrazinamide in Aqueous Acetic Acid Medium", International Letters of Chemistry, Physics and Astronomy, Vol. 16, pp. 1-8, 2013

Online since:

August 2013

Authors:

S. Parimala Vaijayanthi, N. Mathiyalagan

Keywords:

Amino Acids, Kinetics, Mechanism, N-Chloropyrazinamide, Oxidation

Export:

RIS, BibTeX, Text

Distribution:

Open Access

This work is licensed under a
Creative Commons Attribution 4.0 International License

References:

Amauri F. Patrocino, Paulo J. S. Moran, J. Organomet. Chem. 603 (2000) 220-224.

Sameer P. Dhuru, Nikhil U. Mohe, Manikrao M. Salunkhe, Synth. Commun. 31(23) (2001) 3653-3657.

V. Canibano, J. F. Rodriguez, M. Santose, M. A. Sanz-Tejedor, M. C. Carreno, G. Gonzalez, J. L. Garcia-Ruano, Synthesis 14 (2001) 2175-2179.

B. P. Bandgar, L. S. Uppalla, V. S. Sadavarte, Syn. Lett. 11 (2001) 1715-1718.

Duraisamy Thenraja, Perumal Subramaniam, Chockalingam Srinivasan, J. Chem. Soc. Perkin Trans. 2 (2002) 2125-2129.

Teruaki Mukaiyama, Jun-ichi Matsuo, Daisuke Lida, Hideo Kitagawa, Chem. Lett. 8 (2001) 846-847.

N. M. I. Alhaji, S. Sofiya Lawrence Mary, E-J Chem. 8(4) (2011) 1728.

Ashok Kumar Singh, Rajesh Kumar Singh, Jaya Srivastava, Shahla Rahmani, Sarita Yadav, Indian J. Chem. 51A (2012) 681-689.

Hemmige S. Yathirajan, Chapuradoddi R. Raju, Kikkeri N. Mohana, Sheena Shashikanth, Padmarajaiah Nagaraja, Turk. J. Chem. 27 (2003) 571-580.

N. M. I. Alhaji, S. Sofiya Lawrence Mary, E-J Chem. 8(4) (2011) 1472-1477.

L. Pushpalatha, K. Vivekanandan, J. Indian Chem. Soc. 86(5) (2009) 475-480.

L. Pushpalatha, K. Vivekanandan, J. Indian Chem. Soc. 85 (2008) 1027-1031. -d [NCPZA] dt = k3 k4 [NCPZAH +] [Cl -] k1 [PZA].

N. A. Mohamed Farook, R. Prabaharan, S. Rahini, R. Senthil Kumar, G. Rajamahendran, B. Gopala Krishnan, E-J Chem. 1(2), (2004) 127-131.

Puttaswamy, Nirmala Vaz, Proc. Indian Acad. Sci. (Chem. Sci. ) 113(4) (2001) 325-332.

D. S. Mahadevappa, M. Sayeed Ahamed, N. M. Made Gowda, B. Thimme Gowda, Int. J. Chem. Kinet. 15(8) (1983) 775-793.

D. S. Mahadevappa, K. S. Rangappa, N. M. Made Gowda, B. Thimme Gowda, Int. J. Chem. Kinet. 14(11) (1982) 1183-1197.

Y. R. Katre, S. K. Solanki, Sangeeta Patil, Ghanat K. Joshi, Asian J. Chem. 17(1) (2005) 423-428.

D. S. Mahadevappa, Puttaswamy, N. M. Made Gowda, Proc. Indian Acad. Sci. (Chem. Sci. ) 100(4) (1988) 261-274.

M. Puttaswamy, N. Nirmala Vaz, J. Indian Chem. Soc. 81(6) (2004) 479-483.

Mangi Lal Bishnoi, Kalyan K. Banerji, Tetrahedron. 41(24) (1985) 6047-6050.

N. A. Mohamed Farook, G. A. Seyed Dameem, A. Murugesan, M. Kanagaraj, E-J Chem. 1(2) (2004) 132-136.

A. K. Singh, B. Jain, R. Negi, Y. Katre, S. P. Singh, V. K. Sharma, Synth. React. Inorg. Metal-Org Nano-Metal Chem. 40(2) (2010) 71-77.

S. Parimala Vaijayanthi, N. Mathiyalagan, Int. J. Res. Org. Chem. 2(3) (2012) 13-15.

Anjali Lal, M. C. Agrawal, Indian J. Chem. 23A (1984) 411-412.

K. Vivekanandan, K. Nambi, J. Indian Chem. Soc. 76 (1999) 198-201.

Musa E. Mohamed, Abdelhafeez M. A. Mohammed, International Letters of Chemistry, Physics and Astronomy 10(1) (2013) 1-17. ( Received 24 June 2013; accepted 27 June 2013 ).

Show More Hide

Cited By:

This article has no citations.