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International Letters of Chemistry, Physics and Astronomy
Volume 14
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Microwave Assisted Synthesis, Spectral Studies and Antimicrobial Activities of some 2′,4′-Difluorophenyl Chalcones

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Abstract:

Some 2′,4′-difluorophenyl chalcones have been synthesized under microwave irradiation using aldol condensation between 2,4-difluoroacetophenone and substituted benzaldehydes using catalytic amount of hydroxyapatite. The yields of the chalcones are more than 85%. The purities of these synthesized chalcones were examined by their physical constants and spectroscopic data. The UV absorption maxima (λmax, nm), infrared stretches (ν, cm-1) of CO, fingerprint region of CHip/op, CH=CHop, C=Cop modes, NMR chemical shifts (δ, ppm) of vinyl proton, carbon and carbonyl carbons have been assigned and correlated with Hammett substituent constants, F and R parameters using single and multi-regression analysis. From the statistical analysis the effect of substituent on the above spectral frequencies can be discussed. The antimicrobial activities of these synthesized chalcones have been screened using Bauer-Kirby method.

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Periodical:
International Letters of Chemistry, Physics and Astronomy (Volume 14)
Pages:
68-86
Citation:
S. Vijayakumar et al., "Microwave Assisted Synthesis, Spectral Studies and Antimicrobial Activities of some 2′,4′-Difluorophenyl Chalcones", International Letters of Chemistry, Physics and Astronomy, Vol. 14, pp. 68-86, 2013
Online since:
May 2013
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[2] T. Deyou, I. Gumula, F. Pang, A. Gruhonjic, M. Mumo, J. Holleran, S. Duffy, P. Fitzpatrick, M. Heydenreich, G. Landberg, S. Derese, V. Avery, K. Rissanen, M. Erdélyi, A. Yenesew, "Rotenoids, Flavonoids, and Chalcones from the Root Bark of Millettia usaramensis", Journal of Natural Products, Vol. 78, p. 2932, 2015

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