Paper Titles in Periodical
International Letters of Chemistry, Physics and Astronomy
Volume 14

Subscribe

Subscribe to our Newsletter and get informed about new publication regulary and special discounts for subscribers!

ILCPA > Volume 14 > Microwave Assisted Synthesis, Spectral Studies and...
< Back to Volume

Microwave Assisted Synthesis, Spectral Studies and Antimicrobial Activities of some 2′,4′-Difluorophenyl Chalcones

Full Text PDF

Abstract:

Some 2′,4′-difluorophenyl chalcones have been synthesized under microwave irradiation using aldol condensation between 2,4-difluoroacetophenone and substituted benzaldehydes using catalytic amount of hydroxyapatite. The yields of the chalcones are more than 85%. The purities of these synthesized chalcones were examined by their physical constants and spectroscopic data. The UV absorption maxima (λmax, nm), infrared stretches (ν, cm-1) of CO, fingerprint region of CHip/op, CH=CHop, C=Cop modes, NMR chemical shifts (δ, ppm) of vinyl proton, carbon and carbonyl carbons have been assigned and correlated with Hammett substituent constants, F and R parameters using single and multi-regression analysis. From the statistical analysis the effect of substituent on the above spectral frequencies can be discussed. The antimicrobial activities of these synthesized chalcones have been screened using Bauer-Kirby method.

Info:

Periodical:
International Letters of Chemistry, Physics and Astronomy (Volume 14)
Pages:
68-86
DOI:
https://doi.org/10.18052/www.scipress.com/ILCPA.14.68
Citation:
S. Vijayakumar et al., "Microwave Assisted Synthesis, Spectral Studies and Antimicrobial Activities of some 2′,4′-Difluorophenyl Chalcones", International Letters of Chemistry, Physics and Astronomy, Vol. 14, pp. 68-86, 2013
Online since:
Sep 2013
Authors:
S. Vijayakumar, R. Arulkumaran, R. Sundararajan, S.P. Sakthinathan, R. Suresh, D. Kamalakkannan, K. Ranganathan, K. Sathiyamoorthy, V. Mala, Ganesan Vanangamudi, Ganesamoorthy Thirunarayanan
Keywords:
Aldol Condensation, Antimicrobial Activities, Hammett σ Constants, Hydroxyapatite, Microwave Irradiation, Spectral Correlations
Export:
RIS, BibTeX, Text
Distribution:
Open Access

Creative Commons License
This work is licensed under a
Creative Commons Attribution 4.0 International License

References:

[1] Arulkumaran R., Vijayakumar S., Sakthinathan S. P., Kamalakkannan D., Ranganathan K., Suresh R., Sundararajan R., Vanangamudi G., Thirunarayanan G., J. Chil. Chem. Soc. 58(2) (2013) 1553-1559.

DOI: https://doi.org/10.4067/s0717-97072013000200008

[2] (a) Yankep E., Fomumand Z. T., Dangne E., Phytochem. 46 (1997) 591-593.

[3] Thirunarayanan G., Vanangamudi G., E-J. Chem. 4 (1) (2007) 90-97.

[4] Ranganathan K., Arulkumaran R., Kamalakkannan D., Sundararajan R., Sakthinathan S. P., Vijayakumar S., Suresh R., Vanangamudi G., Thirumurthy K., Mayavel P., Thirunrayanan G., Int. J. Pharm. Med. and Bio. SC 1(1) (2012) 62-85.

DOI: https://doi.org/10.1016/j.saa.2012.09.039

[5] Venkat Reddy G, Maitraie G, Narsaiah D, Rambahu B, Rao R, Synth. Commun. 31(18) (2001) 2881-2884.

[6] Mulliken R. S., J. Chem. Phys. 7 (1939) 121-131.

[7] Hsieh H. K., Tsao L. T., Wang J. P., J. Pharm. Pharmacol. 52(2) (2000) 163-171.

[8] Viana G. S., Bandeira M. A., Matos F., J. Phytomed. 10 (2003) 189-195.

[9] Zhao L. M., Jin H. S., Sun L. P., Piao H. R., Quan Z. S., Bioorg. Med. Chem. Lett. 15(22) (2005) 5027-5029.

[10] Mukarami S., Muramatsu M., Aihara H., Otomo S., Biochem. Pharmacol. 42(7) ( 1991) 1447-1451.

[11] Liu M., Wilairat P., Go L. M., J. Med. Chem. 44(5) (2001) 4443-4452.

[12] Francesco E., Salvatore G., Luigi M., Phytochem. 68(7) (2007) 939-953.

[13] Onyilagna J. C., Malhotra B., Elder M., Towers G. H. N., Can. J. Plant. Pathol. 19 (1997) 133-137.

[14] Nielsen S. F., Chen M., Theander T. G., Kharazmi A., Bioorg. Med. Chem. Lett. 5 (1995) 449-452.

[15] Miranda C. L., Aponso G. L. M., J. Agricul Food Chem. 48 (2000) 3876-3884.

[16] Siva Kumar P. M., Geetha Babu S. K., Mukesh D, Chem. Pharm. Bull. 55(1) (2007) 44-49.

[17] Satyanarayana M., Tiwari P., Tripathi K., Srivastava A. K., Pratap R., Bioorg. Med. Chem. Lett. 12 (2004) 883-889.

[18] Barford L., Kemp K., Hansen M., Kharazmi A., Inter Immunopharmacol. 2 (2007) 545.

[19] Maria J., Moa G., Mandado M., Chem. Phy. Lett. 446 (2007) 1-7.

[20] Anto R. J., Sukumaran K., Kuttan G., Rao M. A., Cancer Lett. 97 (1995) 33.

[21] Utpal B, Sahu A, Ali S S, Kasoju L, Singh A, Food Res. Inter. 41 (2008) 1-15.

[22] Subramanian M., Vanangamudi G., Thirunarayanan G., Spectrochim. Acta 110A (2013) 116-123.

[23] Vanangamudi G., Subramanian M., Thirunarayanan G., Arabian J. Chem., 2013. DOI: 10. 1016/j. arabjc. 2013. 03. 006.

[24] Sathiyamoorthi K., Mala V., Suresh R., Sakthinathan S. P., Kamalakkannan D., Ranganathan K., Arulkumaran R., Sundararajan R., Vijayakumar S., Vanangamudi G., Thirunarayanan G., International Letters of Chemistry, Physics and Astronomy 7(2) (2013).

DOI: https://doi.org/10.18052/www.scipress.com/ilcpa.11.77

[25] Sathiyamoorthi K., Mala V., Suresh R., Sakthinathan S. P., Kamalakkannan D., Vanangamudi G., Thirunarayanan G., Spectrochim Acta, 2013. DOI: http: /dx. doi. org/10. 1016/j. saa. 2013. 04. 048.

DOI: https://doi.org/10.5339/connect.2013.7

[26] Mala V., Sathiyamoorthy K., Sakthinathan S. P., Kamalakkannan D., Suresh R., Vanangamudi G., Thirunarayanan G., Q-Science Connect. 2013. DOI: http: /dx. doi. org/10. 5339/connect. (2013).

DOI: https://doi.org/10.5339/connect.2013.7

[27] Bauer A. W., Kirby W. M. M., Sherris J. C., Truck M., Am. J. Clin. Pathol 45 (1966) 493-498.

[28] Dhanaji H., Jadhav Ramaa C.S., Indian J. Chem. 46 (2007) 2064-(2067).

[29] Sachin I., Tabreskhan P., Rhea M., Ramaa C. S., Int. J. Drug Desgn. Discov. 1(3) (2010) 209-215.

[30] Arpita H. More, Jadhav Ramaa C. S., Ind. J. Chem. 49B (2010) 364-367.

[31] Sekar K. G., Thirunarayanan G., International Letters of Chemistry, Physics and Astronomy 8(3) (2013) 249-258.

[32] Ranganathan K., Suresh R., Kamalakkannan D., Arulkumaran R., Sundararajan R., Sakthinathan S. P., Vijayakumar S., Vanangamudi G., Thirumurthy K., Mayavel P., Thirunarayanan G., International Letters of Chemistry, Physics and Astronomy 4 (2012).

DOI: https://doi.org/10.18052/www.scipress.com/ilcpa.4.66

[33] Arulkumaran R., Vijayakumar S., Sundararajan R., Sakthinathan S. P., Kamalakkannan D., Suresh R., Ranganathan K., Rajakumar P. R., Vanangamudi G., Thirunarayanan G., International Letters of Chemistry, Physics and Astronomy 5 (2013) 21-38.

DOI: https://doi.org/10.18052/www.scipress.com/ilcpa.10.21

[34] Sakthinathan S. P., Suresh R., Mala V., Sathiyamoorthi K., Kamalakkannan D., Ranganathan K., Arulkumaran R., Vijayakumar S., Sundararajan R., Vanangamudi G., Thirunarayanan G., International Letters of Chemistry, Physics and Astronomy 6 (2013).

DOI: https://doi.org/10.18052/www.scipress.com/ilcpa.11.77

[35] Sekar K. G., Thirunarayanan G., International Letters of Chemistry, Physics and Astronomy 8(2) (2013) 160-174.

[36] Swain C. G., Lupton E. C. Jr., J. Am. Chem. Soc. 90 (1968) 4328-4337.

[37] Hays W. P., Timmons C. J., Spectrochim. Acta. 24A (1968) 323-334. ( Received 26 April 2013; accepted 29 April 2013 ).

Show More Hide