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International Letters of Chemistry, Physics and Astronomy
Volume 14

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Synthesis, Characterization and Anti-Diabetic Activity of 1,3,5-Triaryl-2-Pyrazolines in Acetic Acid Solution under Ultrasound Irradiation

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Abstract:

A chalcone was prepared by the reaction of 4-methylbenzaldehyde with 4-methylacetophenone in dilute methanolic sodium hydroxide solution under ultrasonic irradiationin the water bath of an ultrasonic cleaner at room temperature. Treatment of this chalcone with thiosemicarbazide/semicarbazide hydrochloride/benzhydrazide/benzenesulphonyl hydrazide/phenylhydrazine hydrochloride afforded the corresponding 2-pyrazoline in good yields. All the new compounds have been characterized by IR, 1H-NMR, 13CNMR spectral data. All the target compounds were evaluated for their In Vivo anti-diabetic activity in rates in comparison with as reference drug.

Info:

Periodical:
International Letters of Chemistry, Physics and Astronomy (Volume 14)
Pages:
172-185
DOI:
10.18052/www.scipress.com/ILCPA.14.172
Citation:
M. Emayavaramban et al., "Synthesis, Characterization and Anti-Diabetic Activity of 1,3,5-Triaryl-2-Pyrazolines in Acetic Acid Solution under Ultrasound Irradiation", International Letters of Chemistry, Physics and Astronomy, Vol. 14, pp. 172-185, 2013
Online since:
Sep 2013
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