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International Letters of Chemistry, Physics and Astronomy
ILCPA Volume 14

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Synthesis, Characterization and Anti-Diabetic Activity of 1,3,5-Triaryl-2-Pyrazolines in Acetic Acid Solution under Ultrasound Irradiation

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A chalcone was prepared by the reaction of 4-methylbenzaldehyde with 4-methylacetophenone in dilute methanolic sodium hydroxide solution under ultrasonic irradiationin the water bath of an ultrasonic cleaner at room temperature. Treatment of this chalcone with thiosemicarbazide/semicarbazide hydrochloride/benzhydrazide/benzenesulphonyl hydrazide/phenylhydrazine hydrochloride afforded the corresponding 2-pyrazoline in good yields. All the new compounds have been characterized by IR, 1H-NMR, 13CNMR spectral data. All the target compounds were evaluated for their In Vivo anti-diabetic activity in rates in comparison with as reference drug.


International Letters of Chemistry, Physics and Astronomy (Volume 14)
M. Emayavaramban et al., "Synthesis, Characterization and Anti-Diabetic Activity of 1,3,5-Triaryl-2-Pyrazolines in Acetic Acid Solution under Ultrasound Irradiation", International Letters of Chemistry, Physics and Astronomy, Vol. 14, pp. 172-185, 2013
Online since:
May 2013

Maiti R., Jana D., Das U. K., Ghosh D., J. Ethnopharmacol 92 (2004) 85-91.

World Health Organization; Fact sheet No-312, November 2009. http: /www. who. int/mediacentre/factsheets/fs312/en/index. html.

Susheela T., Padma Balaravi, Jane Theophilus, Narender Reddy, Reddy P. U. M., Curr. Sci. 94(9) (2008) 1191.

Diabetes Statistics: India Is the Diabetic Capital of The World, http: /health. savvy-cafe. com/diabetes-statistics-india-is-the-diabetic-capital-of-the-world.

Bhupesh C. M., Kamal S., Nagendra S. C., Rohit B., Kalyani D., Int. J. Pharm. 6 (2008) 1-6.

Gerritsen G. C., Dulin W. E., Kalamazoo P. D., Diabetes 14 (1965) 102. Smith D. L., Forist A. A., Dulin W. E., J. Med. Chem. 1965, 350.

ElShora AI., Egypt J. Sol. 23 (2000) 251-254.

Sobhia H. R., Yaminib Y., Esrafili A., Adiba M., J. Pharm, Biomed. Anal. 45 (2008) 316-320.

Nauduri D., Reddy G. B., Pharm. Bull. Tokyo 46 (1998) 1254.

Korgaokar S. S., Patil P. H., Shah M. T., Parekh H. H., Indian J. Pharm. Sci. 58 (1996) 222.

Udupi R. H., Kushnoor A. R., Bhat A. R., Indian J. Heterocyclic Chem. 8 (1998) 63.

Delay F. (S. A. Fermeinch), Patentschriff (Switz) C. A. 117 (1992) 90276f.

Geigy J. R., Belg, 466668, Aug. 31, 1942; C.A., 39 (1945) 7848.

Reddy D. B., Senshama T., Ramma Reddy B. M. V., Indian J. Chem. 30(B) (1991) 46.

Zalgislaw K. Zbigniew, Acta. Pol Pharm 36(6) (1979) 645: C.A., 93 (1980) 204525e.

Yamashita Hiroyuti, Odata Mocoto, Kawazara Hirahi, Namekawa Hiroshi, Eur. Patent appl. Ep1988; 295695CL. Co7D401/6) J. P. Appl. 87(1987)148919, C. A, 111(1989)2351.

Bauer A. N., Kirby W. N. M., Sherries J. C., Truck M., Am. J. Clin. Pathol. 45 (1996) 493 (1996).

Yanarday R., Colak H., Pharm Pharmacol Comno 4 (1998) 309.

Ragini Gupta, Neetu Gupta, Anshu Jain, Indian Journal of Chemistry 49B (2010) 351-355.

Naglaa M. A. E., Tamer S. S., Mohamed F. M., Ultrason. Sonochem. 16 (2009) 70.

C. Guofeng, L. Jitai, D. Huiyun, L. Tongshuang, C. J. I. 6 (1), 6 (2004).

D. Azarifar, M. Shaebanzadeh, Molecules 7 (2002) 885.

Prince S. M., Menon V. P., J. Ethnopharmacol. 70 (2000) 9-15.

Jelodar G., Mohsen M., Shahram S., African J. Traditional, Complementary and Alternative Medicines 3 (2003) 299-305.

Grover J. K., Vats V., Rathi S. S., J. Ethnopharmacol. 73 (2000) 461-470.

Shanmugasundaram K. R., Panneerselvam S. P., Shanmugasundaram E. R. B., R. Br. J. Ethnopharmacol. 7 (1983) 205-216.

Begum N., Shanmugasudnaram K. R., J. Health Sci. 4 (1978) 129-139.

Mohamed A. K., Bierhaus A., Sciekofer S., Tritschler H., Ziegler H., Nawroth P. P., Biofactors 10 (1999) 175. ( Received 08 May 2013; accepted 12 May 2013 ).

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